University of East Anglia

About: University of East Anglia is a education organization based out in Norwich, Norfolk, United Kingdom. It is known for research contribution in the topics: Population & Climate change. The organization has 13250 authors who have published 37504 publications receiving 1669060 citations. The organization is also known as: UEA.

Links between circulation and changes in the characteristics of Iberian rainfall

Abstract: Investigation of the links between atmospheric circulation patterns and rainfall is important for the understanding of climatic variability and for the development of empirical circulation-based downscaling methods. Here, spatial and temporal variations in circulation-rainfall relationships over the Iberian Peninsula during the period 1958–97 are explored using an automated circulation classification scheme and daily rainfall totals for 18 stations. Links between the circulation classification scheme and the North Atlantic oscillation (NAO) are also considered, as are the direct links between rainfall and the NAO. Trends in rainfall and circulation-type frequency are explored. A general tendency towards decreasing mean seasonal rainfall over the peninsula, with the exception of the southeastern Mediterranean coast, hides larger changes in wet day amount and rainfall probability. There is a tendency towards more, less-intensive rain days across much of Iberia, with a tendency towards more, more-intensive rain days along the southeastern Mediterranean coast, both of which are reflected in changes in rainfall amount quantiles. A preliminary analysis indicates that these changes may have occurred systematically across all circulation types. Comparison of the trends in rainfall and in circulation-type frequency suggests possible links. These links are supported by linear regression analyses using circulation-type frequencies as predictor variables and rainfall totals for winter months as the predictands. The selected predictor variables reflect the main circulation features influencing winter rainfall across the peninsula, i.e. the strong influence of Atlantic westerly and southwesterly airmasses over much of the peninsula, of northerly and northwesterly surface flow over northern/northwestern Spain and northern Portugal and the stronger effect of Mediterranean rather than Atlantic influences in southeastern Spain. The observed rainfall changes cannot, however, be explained by changes in circulation alone. Copyright © 2002 Royal Meteorological Society.

A two decade dementia incidence comparison from the Cognitive Function and Ageing Studies I and II

Abstract: Dramatic global increases in future numbers of people with dementia have been predicted. No multicentre population-based study powered to detect changes over time has reported dementia incidence. MRC Cognitive Function and Ageing Study (CFAS) undertook baseline interviews in populations aged 65+ years in England and Wales (1989–1994). Three areas (CFAS I) were selected for new sampling two decades later (2008–2011) with same geographical boundaries, sampling and approach methods (CFAS II). At 2 years CFAS I interviewed 5,156 (76% response) with 5,288 interviewed in CFAS II (74% response). Here we report a 20% drop in incidence (95% CI: 0–40%), driven by a reduction in men across all ages above 65. In the UK we estimate 209,600 new dementia cases per year. This study was uniquely designed to test for differences across geography and time. A reduction of age-specific incidence means that the numbers of people estimated to develop dementia in any year has remained relatively stable.

Matrix metalloproteinases in arthritic disease.

Abstract: The role of matrix metalloproteinases in the degradative events invoked in the cartilage and bone of arthritic joints has long been appreciated and attempts at the development of proteinase inhibitors as potential therapeutic agents have been made. However, the spectrum of these enzymes orchestrating connective tissue turnover and general biology is much larger than anticipated. Biochemical studies of the individual members of the matrix metalloproteinase family are now underway, ultimately leading to a more detailed understanding of the function of their domain structures and to defining their specific role in cellular systems and the way that they are regulated. Coupled with a more comprehensive and detailed study of proteinase expression in different cells of joint tissues during the progress of arthritic diseases, it will be possible for the future development and application of highly specific proteinase inhibitors to be directed at specific key cellular events.

Molecular Engineering of Peripherally And Axially Modified Phthalocyanines for Optical Limiting and Nonlinear Optics

Abstract: Phthalocyanines have remarkable chemical and thermal stability and offer tremendous architectural flexibility in their structure, facilitating the tailoring of physical, optoelectronic, and chemical parameters. In this paper, we summarize experimental measurements of nonlinear optical adsorption in a comprehensive representative series of modified phthalocyanines substituted with various central metals and peripheral functional groups. Rate equations are used to analytically solve the static-state conditions that simulate the excited-state dynamics that result from the nonlinear excited-state adsorption, and this solution is fitted to the experimental data. General molecular engineering trends relating the optical limiting performance of these compounds to their structural characteristics are also explored and discussed.