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Institution

University of East Anglia

EducationNorwich, Norfolk, United Kingdom
About: University of East Anglia is a education organization based out in Norwich, Norfolk, United Kingdom. It is known for research contribution in the topics: Population & Climate change. The organization has 13250 authors who have published 37504 publications receiving 1669060 citations. The organization is also known as: UEA.


Papers
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Journal ArticleDOI
TL;DR: Clinicians and researchers are encouraged to adopt a common language in olfactory dysfunction to increase the methodological quality, consistency and generalisability of work in this field.
Abstract: Background: Olfactory dysfunction is an increasingly recognised condition, associated with reduced quality of life and major health outcomes such as neurodegeneration and death. However, translational research in this field is limited by heterogeneity in methodological approach, including definitions of impairment, improvement and appropriate assessment techniques. Accordingly, effective treatments are limited. In an effort to encourage high quality and comparable work in this field, among others, we propose the following ideas and recommendations. Whilst full recommendations are outlined in the main document, key points include: -Patients with suspected olfactory loss should undergo a full examination of the head and neck, including rigid nasal endoscopy. -Subjective olfactory assessment should not be undertaken in isolation, given its poor reliability. -Psychophysical assessment tools used in clinical and research settings should include reliable and validated tests of odour threshold, and/or one of odour identification or discrimination. -Comprehensive chemosensory assessment should include gustatory screening. -Smell training can be helpful in patients with olfactory loss of several aetiologies. Conclusions: We hope the current manuscript will encourage clinicians and researchers to adopt a common language, and in so doing, increase the methodological quality, consistency and generalisability of work in this field.

473 citations

Journal ArticleDOI
24 Sep 2008-JAMA
TL;DR: Inhaled anticholinergics are associated with a significantly increased risk of cardiovascular death, MI, or stroke among patients with COPD.
Abstract: Context Inhaled anticholinergics (ipratropium bromide or tiotropium bromide) are widely used in patients with chronic obstructive pulmonary disease (COPD) but their effect on the risk of cardiovascular outcomes is unknown. Objective To ascertain the cardiovascular risks of inhaled anticholinergics, including cardiovascular death, myocardial infarction (MI), and stroke. Data Sources Systematic searches were conducted on March 19, 2008, of relevant articles in MEDLINE, the Cochrane Database of systematic reviews, regulatory authority Web sites in the United States and the United Kingdom, and manufacturers' trial registries with no date restrictions. Study Selection Randomized controlled trials of any inhaled anticholinergic for treatment of COPD that had at least 30 days of treatment and reported on cardiovascular events. Data Extraction The primary outcome was a composite of cardiovascular death, MI, or stroke. The secondary outcome was all-cause mortality. Relative risks (RRs) were estimated using fixed-effects models and statistical heterogeneity was estimated with the I2 statistic. Data Synthesis After a detailed screening of 103 articles, 17 trials enrolling 14 783 patients were analyzed. Follow-up duration ranged from 6 weeks to 5 years. Cardiovascular death, MI, or stroke occurred in 135 of 7472 patients (1.8%) receiving inhaled anticholinergics and 86 of 7311 patients (1.2%) receiving control therapy (RR, 1.58 [95% confidence interval {CI}, 1.21-2.06]; P 6 months) confirmed the significantly increased risk of cardiovascular death, MI, or stroke (2.9% of patients treated with anticholinergics vs 1.8% of the control patients; RR, 1.73 [95%CI, 1.27-2.36]; P Conclusion Inhaled anticholinergics are associated with a significantly increased risk of cardiovascular death, MI, or stroke among patients with COPD.

472 citations

Book
01 Nov 2016
TL;DR: The author’s discourses, monologues, letters and diatribes are divided into four sections: literature, philosophy, criticism and criticism.
Abstract: Table of content . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 About the content . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Contains . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 See also . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Editions of this work . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 livres (73) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 enregistrements (10) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 spectacles (4) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 films, vidéos (1) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 Documents about this work

472 citations

Journal ArticleDOI
TL;DR: In this paper, the authors give an overview of the state of the art of environmental value transfer, discuss its prospects and potential role in CBA as a decision-support tool, and provide further guidelines for proper use and application.

471 citations

Journal ArticleDOI
TL;DR: In this article, the authors analyse the problem of estimating the probability of future climate change in the context of adaptation to climate change and conclude that the jury is still out on whether probabilities are useful for climate adaptation policy.

470 citations


Authors

Showing all 13512 results

NameH-indexPapersCitations
George Davey Smith2242540248373
Nicholas J. Wareham2121657204896
Cyrus Cooper2041869206782
Kay-Tee Khaw1741389138782
Phillip A. Sharp172614117126
Rory Collins162489193407
William J. Sutherland14896694423
Shah Ebrahim14673396807
Kenneth M. Yamada13944672136
Martin McKee1381732125972
David Price138168793535
Sheila Bingham13651967332
Philip Jones13564490838
Peter M. Rothwell13477967382
Ivan Reid131131885123
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023115
2022385
20212,203
20202,121
20191,957
20181,798