University of East Anglia

About: University of East Anglia is a education organization based out in Norwich, Norfolk, United Kingdom. It is known for research contribution in the topics: Population & Climate change. The organization has 13250 authors who have published 37504 publications receiving 1669060 citations. The organization is also known as: UEA.

Democracy, deliberation and design: the case of online discussion forums:

Abstract: Within democratic theory, the deliberative variant has assumed pre-eminence. It represents for many the ideal of democracy, and in pursuit of this ideal, online discussion forums have been proposed as solutions to the practical limits to mass deliberation. Critics have pointed to evidence which suggests that online discussion has tended to undermine deliberation. This article argues that this claim, which generates a stand-off between the two camps, misses a key issue: the role played by design in facilitating or thwarting deliberation. It argues that political choices are made both about the format and operation of the online discussion, and that this affects the possibility of deliberation. Evidence for the impact of design (and the choices behind it) is drawn from analysis of European Union and UK discussion forums. This evidence suggests that we should view deliberation as dependent on design and choice, rather than a predetermined product of the technology.

Evidence for a SAL1-PAP Chloroplast Retrograde Pathway That Functions in Drought and High Light Signaling in Arabidopsis

Abstract: Compartmentation of the eukaryotic cell requires a complex set of subcellular messages, including multiple retrograde signals from the chloroplast and mitochondria to the nucleus, to regulate gene expression. Here, we propose that one such signal is a phosphonucleotide (3'-phosphoadenosine 5'-phosphate [PAP]), which accumulates in Arabidopsis thaliana in response to drought and high light (HL) stress and that the enzyme SAL1 regulates its levels by dephosphorylating PAP to AMP. SAL1 accumulates in chloroplasts and mitochondria but not in the cytosol. sal1 mutants accumulate 20-fold more PAP without a marked change in inositol phosphate levels, demonstrating that PAP is a primary in vivo substrate. Significantly, transgenic targeting of SAL1 to either the nucleus or chloroplast of sal1 mutants lowers the total PAP levels and expression of the HL-inducible ASCORBATE PEROXIDASE2 gene. This indicates that PAP must be able to move between cellular compartments. The mode of action for PAP could be inhibition of 5' to 3' exoribonucleases (XRNs), as SAL1 and the nuclear XRNs modulate the expression of a similar subset of HL and drought-inducible genes, sal1 mutants accumulate XRN substrates, and PAP can inhibit yeast (Saccharomyces cerevisiae) XRNs. We propose a SAL1-PAP retrograde pathway that can alter nuclear gene expression during HL and drought stress.

Water Supply and Health

Abstract: As one article in a four-part PLoS Medicine series on water and sanitation, Paul Hunter and colleagues argue that much more effort is needed to improve access to safe and sustainable water supplies.

Competitive conditions in european banking

Abstract: In this paper we utilise the Rosse-Panzar statistic to assess competitive conditions in major EC banking markets between 1986 and 1989. Although EC banking legislation has established relatively free access to member country banking systems in recent years, our results indicate no change in market conduct of banks between 1986 and 1989. The results suggest that banks in Germany, the United Kingdom, France and Spain earned revenues as if under conditions of monopolistic competition in the period. In the case of Italy, they are consistent with banks having earned revenues as if under monopoly or conjectural variations short-run oligopoly conditions. We interpret the results as indicative of a lack of integration in EC banking markets and they thus underline the importance of the Second Banking Directive, the associated supervisory arrangements, and the elimination of capital controls as to achieving full integration.