scispace - formally typeset
Search or ask a question
Institution

University of El Salvador

EducationSan Salvador, El Salvador
About: University of El Salvador is a education organization based out in San Salvador, El Salvador. It is known for research contribution in the topics: Population & Humanities. The organization has 779 authors who have published 601 publications receiving 4777 citations. The organization is also known as: National University of El Salvador.


Papers
More filters
Journal ArticleDOI
TL;DR: Bazedoxifene significantly reduced the risk of new vertebral fracture in postmenopausal women with osteoporosis and decreased the risk in subjects at higher fracture risk and in a posthoc analysis of a subgroup of women atHigher fracture risk.
Abstract: In this 3-yr, randomized, double-blind, placebo- and active-controlled study, healthy postmenopausal women with osteoporosis (55–85 yr of age) were treated with bazedoxifene 20 or 40 mg/d, raloxifene 60 mg/d, or placebo. The primary endpoint was incidence of new vertebral fractures after 36 mo; secondary endpoints included nonvertebral fractures, BMD, and bone turnover markers. Among 6847 subjects in the intent-to-treat population, the incidence of new vertebral fractures was significantly lower (p < 0.05) with bazedoxifene 20 mg (2.3%), bazedoxifene 40 mg (2.5%), and raloxifene 60 mg (2.3%) compared with placebo (4.1%), with relative risk reductions of 42%, 37%, and 42%, respectively. The treatment effect was similar among subjects with or without prevalent vertebral fracture (p = 0.89 for treatment by baseline fracture status interaction). The incidence of nonvertebral fractures with bazedoxifene or raloxifene was not significantly different from placebo. In a posthoc analysis of a subgroup of women at higher fracture risk (femoral neck T-score ≤ –3.0 and/or ≥1 moderate or severe vertebral fracture or multiple mild vertebral fractures; n = 1772), bazedoxifene 20 mg showed a 50% and 44% reduction in nonvertebral fracture risk relative to placebo (p = 0.02) and raloxifene 60 mg (p = 0.05), respectively. Bazedoxifene significantly improved BMD and reduced bone marker levels (p < 0.001 versus placebo). The incidence of vasodilatation, leg cramps, and venous thromboembolic events was higher with bazedoxifene and raloxifene compared with placebo. In conclusion, bazedoxifene significantly reduced the risk of new vertebral fracture in postmenopausal women with osteoporosis and decreased the risk of nonvertebral fracture in subjects at higher fracture risk.

444 citations

Journal ArticleDOI
TL;DR: Agricultural work on lowland sugarcane and cotton plantations was associated with decreased kidney function in men and women, possibly related to strenuous work in hot environments with repeated volume depletion.

228 citations

Journal ArticleDOI
TL;DR: The results suggest that temporal blockade of IL-6 signaling after SCI abrogates damaging inflammatory activity and promotes functional recovery by promoting the formation of alternatively activated M2 macrophages.
Abstract: Background Recent in vivo and in vitro studies in non-neuronal and neuronal tissues have shown that different pathways of macrophage activation result in cells with different properties. Interleukin (IL)-6 triggers the classically activated inflammatory macrophages (M1 phenotype), whereas the alternatively activated macrophages (M2 phenotype) are anti-inflammatory. The objective of this study was to clarify the effects of a temporal blockade of IL-6/IL-6 receptor (IL-6R) engagement, using an anti-mouse IL-6R monoclonal antibody (MR16-1), on macrophage activation and the inflammatory response in the acute phase after spinal cord injury (SCI) in mice.

176 citations

Book
01 Jan 1965
TL;DR: This paper present a cronologia a cerca del caso de los cinco heroes cubanos that data desde el ano 1998 hasta elano 2010.
Abstract: Escrito hace 45 anos, este ensayo capital del Guerrillero Heroico tomo inusitada vigencia tras el derrumbe del modelo socialista sovietico y europeo. Es un claro ejemplo de lucidez dialectica e historica, que permite interpretar las ideas socialistas en el contexto unico de America Latina y el Caribe y, muy en particular, en el caso de Cuba. Revela entero al hombre de pensamiento y paradigma humano del siglo XXI que sin dudas fue Ernesto Guevara. Retomarlo y aprehenderlo hoy ha sido vital para los cubanos. Al final del articulo, se presenta una cronologia a cerca del caso de los cinco heroes cubanos que data desde el ano 1998 hasta el ano 2010

137 citations

Journal ArticleDOI
TL;DR: In this paper, the apparent permeability constants for potassium sorbate and sorbic acid through an edible film composed of methylcellulose and palmitic acid (weight ratio 3:1) were evaluated as a function of water activity (aw) and pH.
Abstract: The apparent permeability constants for potassium sorbate and sorbic acid through an edible film composed of methylcellulose and palmitic acid (weight ratio 3:1) were evaluated as a function of water activity (aw) and pH. For films with thickness 55–66 μm, potassium sorbate permeability increased from 2.3 × 10−10 to 2.0 × 10−8 (mg/sec cm2)(cm)/(mg/mL) as aw increased from 0.65 to 0.80. Films were not stable at aw levels above 0.80. Permeability of the film to sorbic acid at aw 0.8 decreased from 3.3 × 10−8 to 9.1 × 10−10 (mg/sec cm2)(cm)/ (mg/mL) as pH increased from 3 to 7. At pH 3 the undissociated acid was 97.5% and at pH 7 it was 0.4%.

111 citations


Authors
Network Information
Related Institutions (5)
National Autonomous University of Mexico
127.7K papers, 2.2M citations

76% related

University of Buenos Aires
50.9K papers, 1M citations

75% related

Instituto Politécnico Nacional
63.3K papers, 938.5K citations

75% related

University of Salamanca
27.6K papers, 607.3K citations

74% related

University of Murcia
30.3K papers, 616.9K citations

73% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20228
202152
202030
201946
201847
201762