Institution
University of Erlangen-Nuremberg
Education•Erlangen, Bayern, Germany•
About: University of Erlangen-Nuremberg is a education organization based out in Erlangen, Bayern, Germany. It is known for research contribution in the topics: Population & Immune system. The organization has 42405 authors who have published 85600 publications receiving 2663922 citations.
Topics: Population, Immune system, Catalysis, Medicine, Computer science
Papers published on a yearly basis
Papers
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TL;DR: A new algorithm for the numerical integration of functions that are defined on a d-dimensional cube is constructed based on the Clenshaw-Curtis rule for d=1 and on Smolyak's construction to make the best use of the smoothness properties of any (nonperiodic) function.
Abstract: We construct a new algorithm for the numerical integration of functions that are defined on a \(d\)-dimensional cube. It is based on the Clenshaw-Curtis rule for \(d=1\) and on Smolyak's construction. This way we make the best use of the smoothness properties of any (nonperiodic) function. We prove error bounds showing that our algorithm is almost optimal (up to logarithmic factors) for different classes of functions with bounded mixed derivative. Numerical results show that the new method is very competitive, in particular for smooth integrands and \(d \ge 8\).
394 citations
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TL;DR: Endoscopic therapy is highly effective and safe for patients with mAC, with excellent long-term results; in an almost 5-year follow-up of 1000 patients treated with endoscopic resection, there was no mortality and less than 2% had major complications.
394 citations
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Heidelberg University1, Lund University2, University of Dundee3, Pierre-and-Marie-Curie University4, Karolinska Institutet5, Charité6, University of Erlangen-Nuremberg7, Ljubljana University Medical Centre8, University of Perugia9, Radboud University Nijmegen Medical Centre10, university of lille11, French Institute of Health and Medical Research12, University of Bordeaux13, University of Liège14, VU University Medical Center15, Medical University of Łódź16, University of Basel17
TL;DR: IADL requiring higher neuropsychological functioning seem to be most severely affected in patients with MCI, and the development of performance-based assessment instruments should be intensified, as they allow a valid and reliable assessment of subtle IADL deficits in MCI.
Abstract: There is a growing body of evidence that subtle deficits in instrumental activities of daily living (IADL) may be present in mild cognitive impairment (MCI). However, it is not clear if there are IADL domains that are consistently affected across patients with MCI. In this systematic review, therefore, we aimed to summarize research results regarding the performance of MCI patients in specific IADL (sub)domains compared with persons who are cognitively normal and/or patients with dementia. The databases PsycINFO, PubMed and Web of Science were searched for relevant literature in December 2013. Publications from 1999 onward were considered for inclusion. Altogether, 497 articles were retrieved. Reference lists of selected articles were searched for potentially relevant articles. After screening the abstracts of these 497 articles, 37 articles were included in this review. In 35 studies, IADL deficits (such as problems with medication intake, telephone use, keeping appointments, finding things at home and using everyday technology) were documented in patients with MCI. Financial capacity in patients with MCI was affected in the majority of studies. Effect sizes for group differences between patients with MCI and healthy controls were predominantly moderate to large. Performance-based instruments showed slight advantages (in terms of effect sizes) in detecting group differences in IADL functioning between patients with MCI, patients with Alzheimer’s disease and healthy controls. IADL requiring higher neuropsychological functioning seem to be most severely affected in patients with MCI. A reliable identification of such deficits is necessary, as patients with MCI with IADL deficits seem to have a higher risk of converting to dementia than patients with MCI without IADL deficits. The use of assessment tools specifically designed and validated for patients with MCI is therefore strongly recommended. Furthermore, the development of performance-based assessment instruments should be intensified, as they allow a valid and reliable assessment of subtle IADL deficits in MCI, even if a proxy is not available. Another important point to consider when designing new scales is the inclusion of technology-associated IADL. Novel instruments for clinical practice should be time-efficient and easy to administer.
393 citations
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TL;DR: This review combines the valuable existing knowledge in the fields of synthesis, properties and biomedical applications of PGS and PGS-related biomaterials and devices to meet the ever growing demand for replacement tissues and organs.
393 citations
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TL;DR: In this paper, ribociclib plus fulvestrant showed a greater benefit with regard to progression-free survival than fulvestrants alone in postmenopaugmentation.
Abstract: Background In an earlier analysis of this phase 3 trial, ribociclib plus fulvestrant showed a greater benefit with regard to progression-free survival than fulvestrant alone in postmenopau...
393 citations
Authors
Showing all 42831 results
Name | H-index | Papers | Citations |
---|---|---|---|
Hermann Brenner | 151 | 1765 | 145655 |
Richard B. Devereux | 144 | 962 | 116403 |
Manfred Paulini | 141 | 1791 | 110930 |
Daniel S. Berman | 141 | 1363 | 86136 |
Peter Lang | 140 | 1136 | 98592 |
Joseph Sodroski | 138 | 542 | 77070 |
Richard J. Johnson | 137 | 880 | 72201 |
Jun Lu | 135 | 1526 | 99767 |
Michael Schmitt | 134 | 2007 | 114667 |
Jost B. Jonas | 132 | 1158 | 166510 |
Andreas Mussgiller | 127 | 1059 | 73778 |
Matthew J. Budoff | 125 | 1449 | 68115 |
Stefan Funk | 125 | 506 | 56955 |
Markus F. Neurath | 124 | 934 | 62376 |
Jean-Marie Lehn | 123 | 1054 | 84616 |