University of Erlangen-Nuremberg

About: University of Erlangen-Nuremberg is a education organization based out in Erlangen, Bayern, Germany. It is known for research contribution in the topics: Population & Immune system. The organization has 42405 authors who have published 85600 publications receiving 2663922 citations.

Brightly Luminescent and Color-Tunable Formamidinium Lead Halide Perovskite FAPbX3 (X = Cl, Br, I) Colloidal Nanocrystals

Abstract: In the past few years, hybrid organic–inorganic and all-inorganic metal halide perovskite nanocrystals have become one of the most interesting materials for optoelectronic applications. Here, we report a facile and rapid room temperature synthesis of 15–25 nm formamidinium CH(NH2)2PbX3 (X = Cl, Br, I, or mixed Cl/Br and Br/I) colloidal nanocrystals by ligand-assisted reprecipitation (LARP). The cubic and platelet-like nanocrystals with their emission in the range of 415–740 nm, full width at half-maximum (fwhm) of 20–44 nm, and radiative lifetimes of 5–166 ns enable band gap tuning by halide composition as well as by their thickness tailoring; they have a high photoluminescence quantum yield (up to 85%), colloidal and thermodynamic stability. Combined with surface modification that prevents degradation by water, this nanocrystalline material is an ideal candidate for optoelectronic devices and applications. In addition, optoelectronic measurements verify that the photodetector based on FAPbI3 nanocrystals...

Substantial glacier mass loss in the Tien Shan over the past 50 years

Abstract: Populations in Central Asia are heavily dependent on snow and glacier melt for their water supplies. Changes to the glaciers in the main mountain range in this region, the Tien Shan, have been reported over the past decade. However, reconstructions over longer, multi-decadal timescales and the mechanisms underlying these variations—both required for reliable future projections—are not well constrained. Here we use three ensembles of independent approaches based on satellite gravimetry, laser altimetry, and glaciological modelling to estimate the total glacier mass change in the Tien Shan. Results from the three approaches agree well, and allow us to reconstruct a consistent time series of annual mass changes for the past 50 years at the resolution of individual glaciers. We detect marked spatial and temporal variability in mass changes. We estimate the overall decrease in total glacier area and mass from 1961 to 2012 to be 18 ± 6% and 27 ± 15%, respectively. These values correspond to a total area loss of 2,960 ± 1,030 km2, and an average glacier mass-change rate of −5.4 ± 2.8 Gt yr−1. We suggest that the decline is driven primarily by summer melt and, possibly, linked to the combined effects of general climatic warming and circulation variability over the north Atlantic and north Pacific.

A new clinico-pathological classification system for mesial temporal sclerosis

Abstract: We propose a histopathological classification system for hippocampal cell loss in patients suffering from mesial temporal lobe epilepsies (MTLE). One hundred and seventy-eight surgically resected specimens were microscopically examined with respect to neuronal cell loss in hippocampal subfields CA1–CA4 and dentate gyrus. Five distinct patterns were recognized within a consecutive cohort of anatomically well-preserved surgical specimens. The first group comprised hippocampi with neuronal cell densities not significantly different from age matched autopsy controls [no mesial temporal sclerosis (no MTS); n = 34, 19%]. A classical pattern with severe cell loss in CA1 and moderate neuronal loss in all other subfields excluding CA2 was observed in 33 cases (19%), whereas the vast majority of cases showed extensive neuronal cell loss in all hippocampal subfields (n = 94, 53%). Due to considerable similarities of neuronal cell loss patterns and clinical histories, we designated these two groups as MTS type 1a and 1b, respectively. We further distinguished two atypical variants characterized either by severe neuronal loss restricted to sector CA1 (MTS type 2; n = 10, 6%) or to the hilar region (MTS type 3, n = 7, 4%). Correlation with clinical data pointed to an early age of initial precipitating injury (IPI < 3 years) as important predictor of hippocampal pathology, i.e. MTS type 1a and 1b. In MTS type 2, IPIs were documented at a later age (mean 6 years), whereas in MTS type 3 and normal appearing hippocampus (no MTS) the first event appeared beyond the age of 13 and 16 years, respectively. In addition, postsurgical outcome was significantly worse in atypical MTS, especially MTS type 3 with only 28% of patients having seizure relief after 1-year follow-up period, compared to successful seizure control in MTS types 1a and 1b (72 and 73%). Our classification system appears suitable for stratifying the clinically heterogeneous group of MTLE patients also with respect to postsurgical outcome studies.

The mechano‐activated K+ channels TRAAK and TREK‐1 control both warm and cold perception

Abstract: The sensation of cold or heat depends on the activation of specific nerve endings in the skin. This involves heat- and cold-sensitive excitatory transient receptor potential (TRP) channels. However, we show here that the mechano-gated and highly temperature-sensitive potassium channels of the TREK/TRAAK family, which normally work as silencers of the excitatory channels, are also implicated. They are important for the definition of temperature thresholds and temperature ranges in which excitation of nociceptor takes place and for the intensity of excitation when it occurs. They are expressed with thermo-TRP channels in sensory neurons. TRAAK and TREK-1 channels control pain produced by mechanical stimulation and both heat and cold pain perception in mice. Expression of TRAAK alone or in association with TREK-1 controls heat responses of both capsaicin-sensitive and capsaicin-insensitive sensory neurons. Together TREK-1 and TRAAK channels are important regulators of nociceptor activation by cold, particularly in the nociceptor population that is not activated by menthol.

VolumeDeform: Real-Time Volumetric Non-rigid Reconstruction

Abstract: We present a novel approach for the reconstruction of dynamic geometric shapes using a single hand-held consumer-grade RGB-D sensor at real-time rates. Our method builds up the scene model from scratch during the scanning process, thus it does not require a pre-defined shape template to start with. Geometry and motion are parameterized in a unified manner by a volumetric representation that encodes a distance field of the surface geometry as well as the non-rigid space deformation. Motion tracking is based on a set of extracted sparse color features in combination with a dense depth constraint. This enables accurate tracking and drastically reduces drift inherent to standard model-to-depth alignment. We cast finding the optimal deformation of space as a non-linear regularized variational optimization problem by enforcing local smoothness and proximity to the input constraints. The problem is tackled in real-time at the camera’s capture rate using a data-parallel flip-flop optimization strategy. Our results demonstrate robust tracking even for fast motion and scenes that lack geometric features.