University of Exeter

About: University of Exeter is a education organization based out in Exeter, United Kingdom. It is known for research contribution in the topics: Population & Context (language use). The organization has 15820 authors who have published 50650 publications receiving 1793046 citations. The organization is also known as: Exeter University & University of the South West of England.

Subcortical volumetric abnormalities in bipolar disorder

Abstract: Considerable uncertainty exists about the defining brain changes associated with bipolar disorder (BD). Understanding and quantifying the sources of uncertainty can help generate novel clinical hypotheses about etiology and assist in the development of biomarkers for indexing disease progression and prognosis. Here we were interested in quantifying case–control differences in intracranial volume (ICV) and each of eight subcortical brain measures: nucleus accumbens, amygdala, caudate, hippocampus, globus pallidus, putamen, thalamus, lateral ventricles. In a large study of 1710 BD patients and 2594 healthy controls, we found consistent volumetric reductions in BD patients for mean hippocampus (Cohen’s d=−0.232; P=3.50 × 10−7) and thalamus (d=−0.148; P=4.27 × 10−3) and enlarged lateral ventricles (d=−0.260; P=3.93 × 10−5) in patients. No significant effect of age at illness onset was detected. Stratifying patients based on clinical subtype (BD type I or type II) revealed that BDI patients had significantly larger lateral ventricles and smaller hippocampus and amygdala than controls. However, when comparing BDI and BDII patients directly, we did not detect any significant differences in brain volume. This likely represents similar etiology between BD subtype classifications. Exploratory analyses revealed significantly larger thalamic volumes in patients taking lithium compared with patients not taking lithium. We detected no significant differences between BDII patients and controls in the largest such comparison to date. Findings in this study should be interpreted with caution and with careful consideration of the limitations inherent to meta-analyzed neuroimaging comparisons.

Interlocking Interactions, the Diffusion of Innovations in Health Care

Abstract: This article aims to provide a reassessment of the processes of diffusion of innovations into organizations, based on new empirical data. The focus of the article is the latter stages of the diffusion process. The article draws on the results of two studies, which examined the diffusion of innovations in health care in the UK. These projects were a matched pair of qualitative studies, using purposeful selections of comparative case studies. The results demonstrate the ambiguous, contested nature of new scientific knowledge. The highly interactive nature of diffusion, with active adopters is illustrated. There is no evidence of a single adoption decision. The science is socially mediated. The features of context and of actors interlock to influence diffusion.

Evidence for a weakening relationship between interannual temperature variability and northern vegetation activity

Abstract: Satellite-derived Normalized Difference Vegetation Index (NDVI), a proxy of vegetation productivity, is known to be correlated with temperature in northern ecosystems. This relationship, however, may change over time following alternations in other environmental factors. Here we show that above 30°N, the strength of the relationship between the interannual variability of growing season NDVI and temperature (partial correlation coefficient RNDVI-GT) declined substantially between 1982 and 2011. This decrease in RNDVI-GT is mainly observed in temperate and arctic ecosystems, and is also partly reproduced by process-based ecosystem model results. In the temperate ecosystem, the decrease in RNDVI-GT coincides with an increase in drought. In the arctic ecosystem, it may be related to a nonlinear response of photosynthesis to temperature, increase of hot extreme days and shrub expansion over grass-dominated tundra. Our results caution the use of results from interannual time scales to constrain the decadal response of plants to ongoing warming.

The nonlinear development of Görtler vortices in growing boundary layers

Abstract: The Growth of Gortler vortices in boundary layers on concave walls is investigated. It is shown that for vortices of wavelength comparable to the boundary-layer thickness the appropriate linear stability equations cannot be reduced to ordinary differential equations. The partial differential equations governing the linear stability of the flow are solved numerically, and neutral stability is defined by the condition that a dimensionless energy function associated with the flow should have a maximum or minimum when plotted as a function of the downstream variable X. The position of neutral stability is found to depend on how and where the boundary layer is perturbed, so that the concept of a unique neutral curve so familiar in hydrodynamic-stability theory is not tenable in the Gortler problem, except for asymptotically small wavelengths. The results obtained are compared with previous parallel-flow theories and the small-wavelength asymptotic results of Hall (1982a, b), which are found to be reasonably accurate even for moderate values of the wavelength. The parallel-flow theories of the growth of Gortler vortices are found to be irrelevant except for the small-wavelength limit. The main deficiency of the parallel-flow theories is shown to arise from the inability of any ordinary differential approximation to the full partial differential stability equations to describe adequately the decay of the vortex at the edge of the boundary layer. This deficiency becomes intensified as the wavelength of the vortices increases and is the cause of the wide spread of the neutral curves predicted by parallel-flow theories. It is found that for a wall of constant radius of curvature a given vortex imposed on the flow can grow for at most a finite range of values of X. This result is entirely consistent with, and is explicable by the asymptotic results of, Hall (1982a).