Institution
University of Exeter
Education•Exeter, United Kingdom•
About: University of Exeter is a education organization based out in Exeter, United Kingdom. It is known for research contribution in the topics: Population & Context (language use). The organization has 15820 authors who have published 50650 publications receiving 1793046 citations. The organization is also known as: Exeter University & University of the South West of England.
Papers published on a yearly basis
Papers
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TL;DR: It is shown that being a morning person is causally associated with better mental health but does not affect BMI or risk of Type 2 diabetes, and the chronotype loci associate with sleep timing.
Abstract: Being a morning person is a behavioural indicator of a person's underlying circadian rhythm. Using genome-wide data from 697,828 UK Biobank and 23andMe participants we increase the number of genetic loci associated with being a morning person from 24 to 351. Using data from 85,760 individuals with activity-monitor derived measures of sleep timing we find that the chronotype loci associate with sleep timing: the mean sleep timing of the 5% of individuals carrying the most morningness alleles is 25 min earlier than the 5% carrying the fewest. The loci are enriched for genes involved in circadian regulation, cAMP, glutamate and insulin signalling pathways, and those expressed in the retina, hindbrain, hypothalamus, and pituitary. Using Mendelian Randomisation, we show that being a morning person is causally associated with better mental health but does not affect BMI or risk of Type 2 diabetes. This study offers insights into circadian biology and its links to disease in humans.
363 citations
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TL;DR: It is suggested that acute dietary nitrate supplementation with 0.5 L of BR improves cycling economy, as demonstrated by a higher PO for the same VO2 and enhances both 4- and 16.1-km cycling TT performance.
Abstract: Purpose:Dietary nitrate supplementation has been shown to reduce the O2 cost of submaximal exercise and to improve high-intensity exercise tolerance. However, it is presently unknown whether it may enhance performance during simulated competition. The present study investigated the effects o
362 citations
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University of Bristol1, University of Oregon2, Macquarie University3, Imperial College London4, University of Wyoming5, University of Exeter6, Centre national de la recherche scientifique7, Osaka City University8, University of Wisconsin-Madison9, University of New South Wales10, American Museum of Natural History11, Australian National University12, University of Bern13, Slovenian Academy of Sciences and Arts14, Sofia University15, University of Göttingen16, University of Montpellier17, Geological Survey of Denmark and Greenland18, Canadian Forest Service19, University of Newcastle20, École Polytechnique Fédérale de Lausanne21, Monash University22, Australian Nuclear Science and Technology Organisation23, University of Bremen24, UPRRP College of Natural Sciences25, University of Calgary26, University of Tennessee27, University of Cologne28, Virginia Tech29, Russian Academy of Sciences30, University of Wisconsin–Oshkosh31, Sapienza University of Rome32, Katholieke Universiteit Leuven33, University of Chile34, University of Queensland35, University of Münster36, University of the Witwatersrand37, Stockholm University38, Laval University39, University of Franche-Comté40, Geode41, University of Plymouth42, Fordham University43, University of the Free State44, Kyoto Prefectural University45, University of Kansas46, University of Orléans47, University of Geneva48, Central Washington University49, Chinese Academy of Sciences50
TL;DR: This article analyzed sedimentary charcoal records to show that the changes in fire regime over the past 21,000 yrs are predictable from changes in regional climates and showed that fire increases monotonically with changes in temperature and peaks at intermediate moisture levels.
Abstract: Climate is an important control on biomass burning, but the sensitivity of fire to changes in temperature and moisture balance has not been quantified. We analyze sedimentary charcoal records to show that the changes in fire regime over the past 21,000 yrs are predictable from changes in regional climates. Analyses of paleo- fire data show that fire increases monotonically with changes in temperature and peaks at intermediate moisture levels, and that temperature is quantitatively the most important driver of changes in biomass burning over the past 21,000 yrs. Given that a similar relationship between climate drivers and fire emerges from analyses of the interannual variability in biomass burning shown by remote-sensing observations of month-by-month burnt area between 1996 and 2008, our results signal a serious cause for concern in the face of continuing global warming.
362 citations
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Texas Biomedical Research Institute1, University of Dundee2, Wellcome Trust Centre for Human Genetics3, National Institute for Health Research4, University of Oxford5, South London and Maudsley NHS Foundation Trust6, King's College London7, Princess Alexandra Hospital8, University of Queensland9, University College London10, University of London11, Trinity College, Dublin12, Cardiff University13, Wellcome Trust Sanger Institute14, Wellcome Trust15, Queen Mary University of London16, Leicester Royal Infirmary17, St George's, University of London18, University of Cambridge19, University of Leicester20, Glenfield Hospital21, University of Edinburgh22, University of Exeter23, Peninsula College of Medicine and Dentistry24, Ninewells Hospital25
TL;DR: It is concluded that ATM, a gene known to be involved in DNA repair and cell cycle control, plays a role in the effect of metformin upstream of AMP-activated protein kinase, and variation in this gene alters glycemic response to meetformin.
Abstract: Metformin is the most commonly used pharmacological therapy for type 2 diabetes. We report a genome-wide association study for glycemic response to metformin in 1,024 Scottish individuals with type 2 diabetes with replication in two cohorts including 1,783 Scottish individuals and 1,113 individuals from the UK Prospective Diabetes Study. In a combined meta-analysis, we identified a SNP, rs11212617, associated with treatment success (n = 3,920, P = 2.9 × 10(-9), odds ratio = 1.35, 95% CI 1.22-1.49) at a locus containing ATM, the ataxia telangiectasia mutated gene. In a rat hepatoma cell line, inhibition of ATM with KU-55933 attenuated the phosphorylation and activation of AMP-activated protein kinase in response to metformin. We conclude that ATM, a gene known to be involved in DNA repair and cell cycle control, plays a role in the effect of metformin upstream of AMP-activated protein kinase, and variation in this gene alters glycemic response to metformin.
362 citations
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TL;DR: In this paper, a mass-conserving semi-implicit (SI) semi-Lagrangian (SL) discretization of the 2D shallow-water equations and 2D vertical slice equations is extended to the 3D deep-atmosphere, non-hydrostatic global equations.
Abstract: Following previous work on an inherently mass-conserving semi-implicit (SI) semi-Lagrangian (SL) discretization of the two-dimensional (2D) shallow-water equations and 2D vertical slice equations, that approach is here extended to the 3D deep-atmosphere, non-hydrostatic global equations. As with the reduced-dimension versions of this model, an advantage of the approach is that it preserves the same basic structure as a standard, non-mass-conserving, SISL version of the model. Additionally, the model is simply switchable to hydrostatic and/or shallow-atmosphere forms. It is also designed to allow simple switching between various geometries (Cartesian, spherical, spheroidal). The resulting mass-conserving model is applied to a standard set of test problems for such models in spherical geometry and compared with results from the standard SISL version of the model.
361 citations
Authors
Showing all 16338 results
Name | H-index | Papers | Citations |
---|---|---|---|
Frank B. Hu | 250 | 1675 | 253464 |
John C. Morris | 183 | 1441 | 168413 |
David W. Johnson | 160 | 2714 | 140778 |
Kevin J. Gaston | 150 | 750 | 85635 |
Andrew T. Hattersley | 146 | 768 | 106949 |
Timothy M. Frayling | 133 | 500 | 100344 |
Joel N. Hirschhorn | 133 | 431 | 101061 |
Jonathan D. G. Jones | 129 | 417 | 80908 |
Graeme I. Bell | 127 | 531 | 61011 |
Mark D. Griffiths | 124 | 1238 | 61335 |
Tao Zhang | 123 | 2772 | 83866 |
Brinick Simmons | 122 | 691 | 69350 |
Edzard Ernst | 120 | 1326 | 55266 |
Michael Stumvoll | 119 | 655 | 69891 |
Peter McGuffin | 117 | 624 | 62968 |