Institution
University of Exeter
Education•Exeter, United Kingdom•
About: University of Exeter is a education organization based out in Exeter, United Kingdom. It is known for research contribution in the topics: Population & Context (language use). The organization has 15820 authors who have published 50650 publications receiving 1793046 citations. The organization is also known as: Exeter University & University of the South West of England.
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University of Dundee1, Texas Biomedical Research Institute2, Wellcome Trust Centre for Human Genetics3, National Institute for Health Research4, University of Oxford5, South London and Maudsley NHS Foundation Trust6, King's College London7, Princess Alexandra Hospital8, University of Queensland9, University College London10, University of London11, Trinity College, Dublin12, Cardiff University13, Wellcome Trust14, Wellcome Trust Sanger Institute15, Leicester Royal Infirmary16, Queen Mary University of London17, St George's, University of London18, University of Cambridge19, University of Leicester20, Glenfield Hospital21, University of Edinburgh22, Peninsula College of Medicine and Dentistry23, University of Exeter24, Ninewells Hospital25
TL;DR: A genome-wide association study for glycemic response to metformin in 1,024 Scottish individuals with type 2 diabetes with replication in two cohorts including 1,783 Scottish individuals and 1,113 individuals from the UK Prospective Diabetes Study.
Abstract: Metformin is the most commonly used pharmacological therapy for type 2 diabetes. We report a genome-wide association study for glycemic response to metformin in 1,024 Scottish individuals with type 2 diabetes with replication in two cohorts including 1,783 Scottish individuals and 1,113 individuals from the UK Prospective Diabetes Study. In a combined meta-analysis, we identified a SNP, rs11212617, associated with treatment success (n = 3,920, P = 2.9 P×-9, odds ratio = 1.35, 95% CI 1.22-1.49) at a locus containing ATM, the ataxia telangiectasia mutated gene. In a rat hepatoma cell line, inhibition of ATM with KU-55933 attenuated the phosphorylation and activation of AMP-activated protein kinase in response to metformin. We conclude that ATM, a gene known to be involved in DNA repair and cell cycle control, plays a role in the effect of metformin upstream of AMP-activated protein kinase, and variation in this gene alters glycemic response to metformin. © 2011 Nature America, Inc. All rights reserved.
340 citations
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TL;DR: In this paper, a longitudinal study of young people's attitudes to learning was conducted and it was shown that these attitudes can transform in a short period of time and such transformations are often linked, in complex ways, to wider social, economic and cultural contexts.
Abstract: Despite an extensive literature on the subject of learning, very little has been written about the ways in which young people's dispositions to learning transform over time. This article draws upon a longitudinal research project which focused on such transformations. The article centres on the case of Amanda Ball and considers the implications which her story holds for our understanding of learning. It is shown that dispositions can transform in a short period of time and that such transformations are often linked, in complex ways, to wider social, economic and cultural contexts.
339 citations
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TL;DR: Herb-drug interactions undoubtedly do occur and may put individuals at risk, however the present knowledge is incomplete and more research is urgently needed.
Abstract: Aims
The aim of this systematic review was to assess the published clinical evidence on interactions between herbal and conventional drugs.
339 citations
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TL;DR: In this paper, a questionnaire was constructed based on a model derived from the motivation literature to examine students' responses on 16 constructs related to motivation, including French being considered feminine, it not being 'cool' for boys to make an effort at French, and the tendency for boys not to try at anything that appears to be tedious.
Abstract: This article reports on an investigation into the motivation of secondary school students in the South-west of England to learn foreign languages. A questionnaire was constructed based on a model derived from the motivation literature to examine students' responses on 16 constructs related to motivation. This was administered to 228 students in years 7, 8 and 9. The analysis revealed a decrease in motivation with age, and higher level of motivation among girls than boys. It also revealed a strikingly higher motivation to learn German than French, which was even more marked when the boys only were considered. These findings were further investigated using interviews. Both girls and boys were able to provide clear explanations for differences between the genders, as well as for the language differences. These included such aspects as French being considered feminine, it not being 'cool' for boys to be seen to make an effort at French, and the tendency for boys not to try at anything that appears to be tedious.
339 citations
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TL;DR: Assessment of the occurrence of microplastic ingestion in wild fish larvae in the western English Channel provides baseline ecological data illustrating the correlation between waterborne microplastics and the incidence of ingestion in fish larvae.
339 citations
Authors
Showing all 16338 results
Name | H-index | Papers | Citations |
---|---|---|---|
Frank B. Hu | 250 | 1675 | 253464 |
John C. Morris | 183 | 1441 | 168413 |
David W. Johnson | 160 | 2714 | 140778 |
Kevin J. Gaston | 150 | 750 | 85635 |
Andrew T. Hattersley | 146 | 768 | 106949 |
Timothy M. Frayling | 133 | 500 | 100344 |
Joel N. Hirschhorn | 133 | 431 | 101061 |
Jonathan D. G. Jones | 129 | 417 | 80908 |
Graeme I. Bell | 127 | 531 | 61011 |
Mark D. Griffiths | 124 | 1238 | 61335 |
Tao Zhang | 123 | 2772 | 83866 |
Brinick Simmons | 122 | 691 | 69350 |
Edzard Ernst | 120 | 1326 | 55266 |
Michael Stumvoll | 119 | 655 | 69891 |
Peter McGuffin | 117 | 624 | 62968 |