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Institution

University of Exeter

EducationExeter, United Kingdom
About: University of Exeter is a education organization based out in Exeter, United Kingdom. It is known for research contribution in the topics: Population & Climate change. The organization has 15820 authors who have published 50650 publications receiving 1793046 citations. The organization is also known as: Exeter University & University of the South West of England.


Papers
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Journal ArticleDOI
TL;DR: The reduced O2 cost of exercise following increased dietary nitrate intake has important implications for the understanding of the factors that regulate mitochondrial respiration and muscle contractile energetics in humans.
Abstract: Pharmacological sodium nitrate supplementation has been reported to reduce the O2 cost of submaximal exercise in humans. In this study, we hypothesized that dietary supplementation with inorganic n...

678 citations

Journal ArticleDOI
TL;DR: The Lancet Countdown track progress on health and climate change and provides an independent assessment of the health effects of climate change, the implementation of the Paris Agreement, 1 and 3.

676 citations

Journal ArticleDOI
TL;DR: It is apparent that the chalcogen amino acids cysteine, methionine, selenocysteines, and selenomethionine exhibit a unique biological chemistry that is the source of exciting research opportunities.
Abstract: Sulfur and selenium occur in proteins as constituents of the amino acids cysteine, methionine, selenocysteine, and selenomethionine. Recent research underscores that these amino acids are truly exceptional. Their redox activity under physiological conditions allows an amazing variety of posttranslational protein modifications, metal free redox pathways, and unusual chalcogen redox states that increasingly attract the attention of biological chemists. Unlike any other amino acid, the "redox chameleon" cysteine can participate in several distinct redox pathways, including exchange and radical reactions, as well as atom-, electron-, and hydride-transfer reactions. It occurs in various oxidation states in the human body, each of which exhibits distinctive chemical properties (e.g. redox activity, metal binding) and biological activity. The position of selenium in the periodic table between the metals and the nonmetals makes selenoproteins ideal catalysts for many biological redox transformations. It is therefore apparent that the chalcogen amino acids cysteine, methionine, selenocysteine, and selenomethionine exhibit a unique biological chemistry that is the source of exciting research opportunities.

674 citations

Journal ArticleDOI
TL;DR: Observations of hundreds of pests and pathogens reveal an average poleward shift of 2.7±0.8 km yr−1 since 1960, supporting the hypothesis of climate-driven pest movement.
Abstract: The extent to which crop pests and pathogens have altered their latitudinal ranges in response to climate change remains largely unknown. Now observations of hundreds of pests and pathogens reveal an average poleward shift of 2.7±0.8 km yr−1 since 1960, supporting the hypothesis of climate-driven pest movement.

672 citations

Journal ArticleDOI
TL;DR: Coronary revascularization guided by iFR was noninferior to revascularizations guided by FFR with respect to the risk of major adverse cardiac events at 1 year.
Abstract: BackgroundCoronary revascularization guided by fractional flow reserve (FFR) is associated with better patient outcomes after the procedure than revascularization guided by angiography alone. It is unknown whether the instantaneous wave-free ratio (iFR), an alternative measure that does not require the administration of adenosine, will offer benefits similar to those of FFR. MethodsWe randomly assigned 2492 patients with coronary artery disease, in a 1:1 ratio, to undergo either iFR-guided or FFR-guided coronary revascularization. The primary end point was the 1-year risk of major adverse cardiac events, which were a composite of death from any cause, nonfatal myocardial infarction, or unplanned revascularization. The trial was designed to show the noninferiority of iFR to FFR, with a margin of 3.4 percentage points for the difference in risk. ResultsAt 1 year, the primary end point had occurred in 78 of 1148 patients (6.8%) in the iFR group and in 83 of 1182 patients (7.0%) in the FFR group (difference i...

672 citations


Authors

Showing all 16338 results

NameH-indexPapersCitations
Frank B. Hu2501675253464
John C. Morris1831441168413
David W. Johnson1602714140778
Kevin J. Gaston15075085635
Andrew T. Hattersley146768106949
Timothy M. Frayling133500100344
Joel N. Hirschhorn133431101061
Jonathan D. G. Jones12941780908
Graeme I. Bell12753161011
Mark D. Griffiths124123861335
Tao Zhang123277283866
Brinick Simmons12269169350
Edzard Ernst120132655266
Michael Stumvoll11965569891
Peter McGuffin11762462968
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023295
2022782
20214,412
20204,192
20193,721
20183,385