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Institution

University of Exeter

EducationExeter, United Kingdom
About: University of Exeter is a education organization based out in Exeter, United Kingdom. It is known for research contribution in the topics: Population & Climate change. The organization has 15820 authors who have published 50650 publications receiving 1793046 citations. The organization is also known as: Exeter University & University of the South West of England.


Papers
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Journal ArticleDOI
Eleftheria Zeggini1, Laura J. Scott2, Richa Saxena, Benjamin F. Voight, Jonathan Marchini3, T Hu2, de Bakker Piw.4, de Bakker Piw.5, de Bakker Piw.6, Gonçalo R. Abecasis2, Peter Almgren7, Gregers S. Andersen8, Kristin Ardlie6, Kristina Bengtsson Boström, Richard N. Bergman9, Lori L. Bonnycastle10, Knut Borch-Johnsen11, Knut Borch-Johnsen8, Noël P. Burtt6, H Chen12, Peter S. Chines10, Mark J. Daly, P Deodhar10, Ding C-J.2, Doney Asf.13, William L. Duren2, Katherine S. Elliott1, Mike Erdos10, Timothy M. Frayling14, Rachel M. Freathy14, Lauren Gianniny6, Harald Grallert, Niels Grarup8, Christopher J. Groves3, Candace Guiducci6, Torben Hansen8, Christian Herder15, Graham A. Hitman16, Thomas Edward Hughes12, Bo Isomaa, Anne U. Jackson2, Torben Jørgensen17, Augustine Kong18, Kari Kubalanza10, Finny G Kuruvilla6, Finny G Kuruvilla5, Johanna Kuusisto19, Claudia Langenberg20, Hana Lango14, Torsten Lauritzen21, Yun Li2, Cecilia M. Lindgren1, Cecilia M. Lindgren3, Valeriya Lyssenko7, Amanda F. Marvelle22, Christine Meisinger, Kristian Midthjell23, Karen L. Mohlke22, Mario A. Morken10, Andrew D. Morris13, Narisu Narisu10, Peter M. Nilsson7, Katharine R. Owen3, Palmer Cna.13, Felicity Payne24, Perry Jrb.14, E Pettersen23, Carl Platou23, Inga Prokopenko3, Inga Prokopenko1, Lu Qi5, Lu Qi4, L Qin22, Nigel W. Rayner1, Nigel W. Rayner3, Matthew G. Rees10, J J Roix12, A Sandbaek11, Beverley M. Shields, Marketa Sjögren7, Valgerdur Steinthorsdottir18, Heather M. Stringham2, Amy J. Swift10, Gudmar Thorleifsson18, Unnur Thorsteinsdottir18, Nicholas J. Timpson1, Nicholas J. Timpson25, Tiinamaija Tuomi26, Jaakko Tuomilehto26, Mark Walker27, Richard M. Watanabe9, Michael N. Weedon14, Cristen J. Willer2, Thomas Illig, Kristian Hveem23, Frank B. Hu5, Frank B. Hu4, Markku Laakso19, Kari Stefansson18, Oluf Pedersen11, Oluf Pedersen8, Nicholas J. Wareham20, Inês Barroso24, Andrew T. Hattersley14, Francis S. Collins10, Leif Groop26, Leif Groop7, Mark I. McCarthy3, Mark I. McCarthy1, Michael Boehnke2, David Altshuler 
TL;DR: The results illustrate the value of large discovery and follow-up samples for gaining further insights into the inherited basis of T2D, and detect at least six previously unknown loci with robust evidence for association.
Abstract: Genome-wide association (GWA) studies have identified multiple loci at which common variants modestly but reproducibly influence risk of type 2 diabetes (T2D). Established associations to common and rare variants explain only a small proportion of the heritability of T2D. As previously published analyses had limited power to identify variants with modest effects, we carried out meta-analysis of three T2D GWA scans comprising 10,128 individuals of European descent and approximately 2.2 million SNPs (directly genotyped and imputed), followed by replication testing in an independent sample with an effective sample size of up to 53,975. We detected at least six previously unknown loci with robust evidence for association, including the JAZF1 (P = 5.0 x 10(-14)), CDC123-CAMK1D (P = 1.2 x 10(-10)), TSPAN8-LGR5 (P = 1.1 x 10(-9)), THADA (P = 1.1 x 10(-9)), ADAMTS9 (P = 1.2 x 10(-8)) and NOTCH2 (P = 4.1 x 10(-8)) gene regions. Our results illustrate the value of large discovery and follow-up samples for gaining further insights into the inherited basis of T2D.

1,872 citations

Journal ArticleDOI
TL;DR: This review critically evaluates the current literature on the presence, behaviour and fate of microplastics in freshwater and terrestrial environments and, where appropriate, draws on relevant studies from other fields including nanotechnology, agriculture and waste management.

1,864 citations

Journal ArticleDOI
TL;DR: It is shown that microplastics are ingested by, and may impact upon, zooplankton, and imply that marine microplastic debris can negatively impact upon zoopLankton function and health.
Abstract: Small plastic detritus, termed “microplastics”, are a widespread and ubiquitous contaminant of marine ecosystems across the globe. Ingestion of microplastics by marine biota, including mussels, worms, fish, and seabirds, has been widely reported, but despite their vital ecological role in marine food-webs, the impact of microplastics on zooplankton remains under-researched. Here, we show that microplastics are ingested by, and may impact upon, zooplankton. We used bioimaging techniques to document ingestion, egestion, and adherence of microplastics in a range of zooplankton common to the northeast Atlantic, and employed feeding rate studies to determine the impact of plastic detritus on algal ingestion rates in copepods. Using fluorescence and coherent anti-Stokes Raman scattering (CARS) microscopy we identified that thirteen zooplankton taxa had the capacity to ingest 1.7–30.6 μm polystyrene beads, with uptake varying by taxa, life-stage and bead-size. Post-ingestion, copepods egested faecal pellets lade...

1,832 citations

Journal ArticleDOI
Georg Ehret1, Georg Ehret2, Georg Ehret3, Patricia B. Munroe4  +388 moreInstitutions (110)
06 Oct 2011-Nature
TL;DR: A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function, and these findings suggest potential novel therapeutic pathways for cardiovascular disease prevention.
Abstract: Blood pressure is a heritable trait(1) influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (>= 140 mm Hg systolic blood pressure or >= 90 mm Hg diastolic blood pressure)(2). Even small increments in blood pressure are associated with an increased risk of cardiovascular events(3). This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3-GUCY1B3, NPR3-C5orf23, ADM, FURIN-FES, GOSR2, GNAS-EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention.

1,829 citations

Journal ArticleDOI
TL;DR: In this article, the authors present a framework for understanding and supporting efforts aimed at "responsibly innovation" in emerging science and innovation, which is a major challenge for contemporary democracies.

1,826 citations


Authors

Showing all 16338 results

NameH-indexPapersCitations
Frank B. Hu2501675253464
John C. Morris1831441168413
David W. Johnson1602714140778
Kevin J. Gaston15075085635
Andrew T. Hattersley146768106949
Timothy M. Frayling133500100344
Joel N. Hirschhorn133431101061
Jonathan D. G. Jones12941780908
Graeme I. Bell12753161011
Mark D. Griffiths124123861335
Tao Zhang123277283866
Brinick Simmons12269169350
Edzard Ernst120132655266
Michael Stumvoll11965569891
Peter McGuffin11762462968
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023295
2022782
20214,412
20204,192
20193,721
20183,385