Institution
University of Extremadura
Education•Badajoz, Spain•
About: University of Extremadura is a education organization based out in Badajoz, Spain. It is known for research contribution in the topics: Population & Hyperspectral imaging. The organization has 7856 authors who have published 18299 publications receiving 396126 citations. The organization is also known as: Universidad de Extremadura.
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TL;DR: A new spectrophotometric method for resolving binary mixtures of salicylic and salicyluric acids is proposed, based on use of the first derivative of the ratios of spectra.
338 citations
TL;DR: Ano1 labels all classes of ICC and represents a highly specific marker for studying the distribution of ICC in mouse and human tissues with an advantage over Kit since it does not label mast cells.
Abstract: Populations of interstitial cells of Cajal (ICC) are altered in several gastrointestinal neuromuscular disorders. ICC are identified typically by ultrastructure and expression of Kit (CD117), a protein that is also expressed on mast cells. No other molecular marker currently exists to independently identify ICC. The expression of ANO1 (DOG1, TMEM16A), a Ca2+-activated Cl− channel, in gastrointestinal stromal tumors suggests it may be useful as an ICC marker. The aims of this study were therefore to determine the distribution of Ano1 immunoreactivity compared with Kit and to establish whether Ano1 is a reliable marker for human and mouse ICC. Expression of Ano1 in human and mouse stomach, small intestine, and colon was investigated by immunofluorescence labeling using antibodies to Ano1 alone and in combination with antibodies to Kit. Colocalization of immunoreactivity was demonstrated by epifluorescence and confocal microscopy. In the muscularis propria, Ano1 immunoreactivity was restricted to cells with the morphology and distribution of ICC. All Ano1-positive cells in the muscularis propria were also Kit positive. Kit-expressing mast cells were not Ano1 positive. Some non-ICC in the mucosa and submucosa of human tissues were Ano1 positive but Kit negative. A few (3.2%) Ano1-positive cells in the human gastric muscularis propria were labeled weakly for Kit. Ano1 labels all classes of ICC and represents a highly specific marker for studying the distribution of ICC in mouse and human tissues with an advantage over Kit since it does not label mast cells.
337 citations
TL;DR: In this article, the authors propose that organizational learning acts as a forerunner of a firm's ability to adapt to evolving market con- ditions (strategic flexibility), and that OL and flexibility simultaneously foster the implementation of differentiation and cost-leadership strategies.
335 citations
TL;DR: The achievements of thirty years of imaging spectroscopy are summarized and the community is strongly recommended to increase its efforts to convince relevant stakeholders of the urgency to acquire the highest quality imaging spectrometer data for Earth observation from operational satellites capable of collecting consistent data for climatically-relevant periods of time.
334 citations
TL;DR: A class of finite difference methods for solving fractional diffusion equations is considered, an extension of the weighted average methods for ordinary (non-fractional) diffusion equations, and a simple and accurate stability criterion valid for different discretization schemes of the fractional derivative, arbitrary weight factor, and arbitrary order is found.
333 citations
Authors
Showing all 8001 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Russel J. Reiter | 169 | 1646 | 121010 |
| Donald G. Truhlar | 165 | 1518 | 157965 |
| Manel Esteller | 146 | 713 | 96429 |
| David J. Williams | 107 | 2060 | 62440 |
| Keijo Häkkinen | 99 | 421 | 31355 |
| Robert H. Anderson | 97 | 1237 | 41250 |
| Leif Bertilsson | 87 | 321 | 23933 |
| Mario F. Fraga | 84 | 267 | 32957 |
| YangQuan Chen | 84 | 1048 | 36543 |
| Antonio Plaza | 79 | 631 | 29775 |
| Robert D. Gibbons | 75 | 349 | 26330 |
| Jocelyn Chanussot | 73 | 614 | 27949 |
| Naresh Magan | 72 | 400 | 17511 |
| Luis Puelles | 71 | 269 | 19858 |
| Jun Li | 70 | 799 | 19510 |