University of Extremadura

About: University of Extremadura is a education organization based out in Badajoz, Spain. It is known for research contribution in the topics: Population & Hyperspectral imaging. The organization has 7856 authors who have published 18299 publications receiving 396126 citations. The organization is also known as: Universidad de Extremadura.

Two direct Tustin discretization methods for fractional-order differentiator/integrator

Abstract: This paper deals with fractional calculus and its approximate discretization. Two direct discretization methods useful in control and digital filtering are presented for discretizing the fractional-order differentiator or integrator. Detailed mathematical formulae and tables are given. An illustrative example is presented to show the practically usefulness of the two proposed discretization schemes. Comparative remarks between the two methods are also given.

Feasibility, reliability, and validity of the EQ-5D-Y: Results from a multinational study

Abstract: Purpose To examine the feasibility, reliability, and validity of the newly developed EQ-5D-Y.

Incorporation of Pharmacogenomics into Routine Clinical Practice: the Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline Development Process

Abstract: The Clinical Pharmacogenetics Implementation Consortium (CPIC) publishes genotype-based drug guidelines to help clinicians understand how available genetic test results could be used to optimize drug therapy. CPIC has focused initially on well-known examples of pharmacogenomic associations that have been implemented in selected clinical settings, publishing nine to date. Each CPIC guideline adheres to a standardized format and includes a standard system for grading levels of evidence linking genotypes to phenotypes and assigning a level of strength to each prescribing recommendation. CPIC guidelines contain the necessary information to help clinicians translate patient-specific diplotypes for each gene into clinical phenotypes or drug dosing groups. This paper reviews the development process of the CPIC guidelines and compares this process to the Institute of Medicine's Standards for Developing Trustworthy Clinical Practice Guidelines.