Institution
University of Extremadura
Education•Badajoz, Spain•
About: University of Extremadura is a education organization based out in Badajoz, Spain. It is known for research contribution in the topics: Population & Hyperspectral imaging. The organization has 7856 authors who have published 18299 publications receiving 396126 citations. The organization is also known as: Universidad de Extremadura.
Papers published on a yearly basis
Papers
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TL;DR: Three methods for calculating the isoelectric points (pI) of proteins, provided that their amino acid compositions are known, are described.
147 citations
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TL;DR: An improvement in the decomposition of the phenolic acid in the combined UV/H2O2 oxidation is observed, due to the generation of OH radicals, and the contribution of the radical reaction to the global process is determined.
147 citations
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TL;DR: Adsorption on carbon materials has been shown to be an effective treatment for the removal of two representative pharmaceutical compounds (carbamazepine, CBZ, and ciprofloxacin, CPX) in ultrapure water, as isolated compounds and as a mixture of both of them as discussed by the authors.
146 citations
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TL;DR: Data suggest that the G2019S mutation induces autophagy via MEK/ERK pathway and that the inhibition of this exacerbated autophagic activity reduces the sensitivity observed in G 2019S mutant cells.
Abstract: Mutations in leucine-rich repeat kinase 2 (LRRK2) are a major cause of familial Parkinsonism, and the G2019S mutation of LRRK2 is one of the most prevalent mutations. The deregulation of autophagic processes in nerve cells is thought to be a possible cause of Parkinson’s disease (PD). In this study, we observed that G2019S mutant fibroblasts exhibited higher autophagic activity levels than control fibroblasts. Elevated levels of autophagic activity can trigger cell death, and in our study, G2019S mutant cells exhibited increased apoptosis hallmarks compared to control cells. LRRK2 is able to induce the phosphorylation of MAPK/ERK kinases (MEK). The use of 1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene (U0126), a highly selective inhibitor of MEK1/2, reduced the enhanced autophagy and sensibility observed in G2019S LRRK2 mutation cells. These data suggest that the G2019S mutation induces autophagy via MEK/ERK pathway and that the inhibition of this exacerbated autophagy reduces the sensitivity observed in G2019S mutant cells.
146 citations
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TL;DR: The training program was feasible and effective in reducing fear of falling and improving dynamic balance and isometric strength in institutionalised older people withFear of falling.
146 citations
Authors
Showing all 8001 results
Name | H-index | Papers | Citations |
---|---|---|---|
Russel J. Reiter | 169 | 1646 | 121010 |
Donald G. Truhlar | 165 | 1518 | 157965 |
Manel Esteller | 146 | 713 | 96429 |
David J. Williams | 107 | 2060 | 62440 |
Keijo Häkkinen | 99 | 421 | 31355 |
Robert H. Anderson | 97 | 1237 | 41250 |
Leif Bertilsson | 87 | 321 | 23933 |
Mario F. Fraga | 84 | 267 | 32957 |
YangQuan Chen | 84 | 1048 | 36543 |
Antonio Plaza | 79 | 631 | 29775 |
Robert D. Gibbons | 75 | 349 | 26330 |
Jocelyn Chanussot | 73 | 614 | 27949 |
Naresh Magan | 72 | 400 | 17511 |
Luis Puelles | 71 | 269 | 19858 |
Jun Li | 70 | 799 | 19510 |