University of Florence

About: University of Florence is a education organization based out in Florence, Toscana, Italy. It is known for research contribution in the topics: Population & Carbonic anhydrase. The organization has 27292 authors who have published 79599 publications receiving 2341684 citations. The organization is also known as: Università degli studi di Firenze & Universita degli studi di Firenze.

Anoikis: an emerging hallmark in health and diseases

Abstract: Anoikis is a programmed cell death occurring upon cell detachment from the correct extracellular matrix, thus disrupting integrin ligation. It is a critical mechanism in preventing dysplastic cell growth or attachment to an inappropriate matrix. Anoikis prevents detached epithelial cells from colonizing elsewhere and is thus essential for tissue homeostasis and development. As anchorage-independent growth and epithelial-mesenchymal transition, two features associated with anoikis resistance, are crucial steps during tumour progression and metastatic spreading of cancer cells, anoikis deregulation has now evoked particular attention from the scientific community. The aim of this review is to analyse the molecular mechanisms governing both anoikis and anoikis resistance, focusing on their regulation in physiological processes, as well as in several diseases, including metastatic cancers, cardiovascular diseases and diabetes.

Single-Molecule Magnet Behavior of a Tetranuclear Iron(III) Complex. The Origin of Slow Magnetic Relaxation in Iron(III) Clusters

Abstract: The synthesis, crystal structure, and magnetic characterization of a novel tetranuclear iron(III) methoxo-bridged cluster of formula Fe4(OCH3)6(dpm)6 (where Hdpm = dipivaloylmethane) is reported. The cluster has a ground spin state of S = 5, which is selectively populated below 20 K. High-field EPR spectra revealed that the system has a uniaxial magnetic anisotropy, corresponding to a zero field splitting parameter D = −0.2 cm-1 of the S = 5. Such anisotropy below 1 K gives rise to the slow relaxation of the magnetization similar to that of super-paramagnets. To investigate the origin of the magnetic anisotropy we have evaluated the projection of the single-ion and dipolar contributions to the zfs of the ground state. The zfs tensors of the three structurally independent iron(III) centers have been calculated from the coordination geometry and spectroscopic data using the angular overlap model. To test the reliability of the approach high-field EPR spectra of the parent monomer Fe(dpm)3 have been recorded...