University of Florence

About: University of Florence is a education organization based out in Florence, Toscana, Italy. It is known for research contribution in the topics: Population & Carbonic anhydrase. The organization has 27292 authors who have published 79599 publications receiving 2341684 citations. The organization is also known as: Università degli studi di Firenze & Universita degli studi di Firenze.

Body weight loss reverts obesity-associated hypogonadotropic hypogonadism: a systematic review and meta-analysis

Abstract: Objective: Few randomized clinical studies have evaluated the impact of diet and physical activity on testosterone levels in obese men with conflicting results. Conversely, studies on bariatric surgery in men generally have shown an increase in testosterone levels. The aim of this study is to perform a systematic review and meta-analysis of available trials on the effect of body weight loss on sex hormones levels. Design: Meta-analysis. Methods: An extensive Medline search was performed including the following words: ‘testosterone’, ‘diet’, ‘weight loss’, ‘bariatric surgery’, and ‘males’. The search was restricted to data from January 1, 1969 up to August 31, 2012. Results: Out of 266 retrieved articles, 24 were included in the study. Of the latter, 22 evaluated the effect of diet or bariatric surgery, whereas two compared diet and bariatric surgery. Overall, both a lowcalorie diet and bariatric surgery are associated with a significant (P!0.0001) increase in plasma sex hormone-binding globulin-bound and -unbound testosterone levels (total testosterone (TT)), with bariatric surgery being more effective in comparison with the low-calorie diet (TT increase: 8.73 (6.51‐10.95) vs 2.87 (1.68‐4.07) for bariatric surgery and the low-calorie diet, respectively; both P!0.0001 vs baseline). Androgen rise is greater in those patients who lose more weight as well as in younger, non-diabetic subjects with a greater degree of obesity. Body weight loss is also associated with a decrease in estradiol and an increase in gonadotropins levels. Multiple regression analysis shows that the degree of body weight loss is the best determinant of TT rise (BZ2.50G0.98, PZ0.029). Conclusions: These data show that weight loss is associated with an increase in both bound and unbound testosterone levels. The normalization of sex hormones induced by body weight loss is a possible mechanism contributing to the beneficial effects of surgery in morbid obesity.

DISULFIND: a disulfide bonding state and cysteine connectivity prediction server

Abstract: DISULFIND is a server for predicting the disulfide bonding state of cysteines and their disulfide connectivity starting from sequence alone. Optionally, disulfide connectivity can be predicted from sequence and a bonding state assignment given as input. The output is a simple visualization of the assigned bonding state (with confidence degrees) and the most likely connectivity patterns. The server is available at http://disulfind.dsi.unifi.it/.

Measurement of Higgs boson production and properties in the WW decay channel with leptonic final states

Abstract: A search for the standard model Higgs boson decaying to a W-boson pair at the LHC is reported. The event sample corresponds to an integrated luminosity of 4.9 fb−1 and 19.4 fb−1 collected with the CMS detector in pp collisions at s√ = 7 and 8 TeV, respectively. The Higgs boson candidates are selected in events with two or three charged leptons. An excess of events above background is observed, consistent with the expectation from the standard model Higgs boson with a mass of around 125 GeV. The probability to observe an excess equal or larger than the one seen, under the background-only hypothesis, corresponds to a significance of 4.3 standard deviations for m H = 125.6 GeV. The observed signal cross section times the branching fraction to WW for m H = 125.6 GeV is 0.72+0.20−0.18 times the standard model expectation. The spin-parity J P = 0+ hypothesis is favored against a narrow resonance with J P = 2+ or J P = 0− that decays to a W-boson pair. This result provides strong evidence for a Higgs-like boson decaying to a W-boson pair.

The Effect of Radiation Pressure on Virial Black Hole Mass Estimates and the Case of Narrow-Line Seyfert 1 Galaxies

Abstract: We consider the effect of radiation pressure from ionizing photons on black hole (BH) mass estimates based on the application of the virial theorem to broad emission lines in AGN spectra. BH masses based only on the virial product Delta(VR)-R-2 and neglecting the effect of radiation pressure can be severely underestimated, especially in objects close to the Eddington limit. We provide an empirical calibration of the correction for radiation pressure, and we show that it is consistent with a simple physical model in which BLR clouds are optically thick to ionizing radiation and have average column densities of N-H similar to 10(23) cm(-2). This value is remarkably similar to what is required in standard BLR photoionization models to explain observed spectra. With the inclusion of radiation pressure, the discrepancy between virial BH masses based on single-epoch spectra and on reverberation mapping data drops from 0.4 to 0.2 dex rms. The use of single-epoch observations as surrogates of reverberation mapping campaigns can thus provide more accurate BH masses than previously thought. Finally, we show that narrow-line Seyfert 1 (NLS1) galaxies have apparently low BH masses because they are radiating close to their Eddington limit. After the radiation pressure correction, NLS1 galaxies have BH masses similar to other broad-line AGNs and follow the same M-BH-sigma(e)/L-sph relations as other active and normal galaxies. Radiation forces arising from ionizing photon momentum deposition constitute an important physical effect which must be taken into account when computing virial BH masses.