Institution
University of Florence
Education•Florence, Toscana, Italy•
About: University of Florence is a education organization based out in Florence, Toscana, Italy. It is known for research contribution in the topics: Population & Carbonic anhydrase. The organization has 27292 authors who have published 79599 publications receiving 2341684 citations. The organization is also known as: Università degli studi di Firenze & Universita degli studi di Firenze.
Papers published on a yearly basis
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TL;DR: The accumulation in the conjunctiva of patients with vernal conjunctivitis of CD4+ T cells that, apart from the production of IL-2, resembles murine Th2 cells for their profile of cytokine production and helper function suggests a possible role for these cells in the pathogenesis of the disease.
Abstract: A total number of 132 T cell clones (TCC) were obtained by PHA-stimulation of single T cells from mononuclear cell suspensions of conjunctival flogistic infiltrates of three patients with vernal conjunctivitis (VC). The phenotype and functional properties of these TCC were compared with those of 122 TCC contemporarily established from PB mononuclear cell suspensions of the same patients, 120 TCC established from lymph nodes of three patients with nonspecific hyperplastic lymphoadenitis and 159 TCC established from thyroid lymphocyte infiltrates of three patients with Graves' disease. The great majority of conjunctival TCC displayed the CD4+ CD8- phenotype (CD4/CD8 ratios ranging from 6.1 to 7.0), whereas the mean CD4/CD8 ratios for control TCC ranged from 0.9 to 2.4. After stimulation with either PHA or PMA plus anti-CD3 mAb, conjunctival TCC differed from control TCC for their ability to produce cytokines. In particular, a large number of conjunctival TCC produced IL-4, but no, or limited amounts of, IFN-gamma, whereas no difference was observed between conjunctival and control TCC with regard to the production of IL-2. The failure of IFN-gamma production by conjunctival TCC was apparently not caused by delay or block in cytokine production, but actually reflected the lack of IFN-gamma transcription. Virtually all conjunctival TCC able to produce IL-4, but not IFN-gamma, as well as most of those producing both cytokines, provided helper function for IgE synthesis in allogeneic normal B cells. The accumulation in the conjunctiva of patients with vernal conjunctivitis of CD4+ T cells that, apart from the production of IL-2, resembles murine Th2 cells for their profile of cytokine production and helper function suggests a possible role for these cells in the pathogenesis of the disease.
303 citations
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Memorial Sloan Kettering Cancer Center1, Kyoto University2, Harvard University3, University of Pavia4, Leeds Teaching Hospitals NHS Trust5, University of Göttingen6, Karolinska Institutet7, University of Düsseldorf8, Paris Descartes University9, University of Bologna10, Hannover Medical School11, Federal University of Ceará12, University of Florence13, Democritus University of Thrace14, University of Oxford15, Gifu University16, Chulalongkorn University17, University of Rochester18, Vanderbilt University19, Carlos III Health Institute20, University of Paris21, University of York22, Leipzig University23, Medical University of Vienna24, University of Tsukuba25, Nagasaki University26, University of Rome Tor Vergata27, Chang Gung University28, Radboud University Nijmegen29, Howard Hughes Medical Institute30, University of California, San Diego31, Stanford University32
TL;DR: Clinical sequencing across a large prospective cohort of patients with myelodysplasic syndrome uncovers distinct associations between the mono- and biallelic states of TP53 and clinical presentation.
Abstract: Tumor protein p53 (TP53) is the most frequently mutated gene in cancer1,2. In patients with myelodysplastic syndromes (MDS), TP53 mutations are associated with high-risk disease3,4, rapid transformation to acute myeloid leukemia (AML)5, resistance to conventional therapies6–8 and dismal outcomes9. Consistent with the tumor-suppressive role of TP53, patients harbor both mono- and biallelic mutations10. However, the biological and clinical implications of TP53 allelic state have not been fully investigated in MDS or any other cancer type. We analyzed 3,324 patients with MDS for TP53 mutations and allelic imbalances and delineated two subsets of patients with distinct phenotypes and outcomes. One-third of TP53-mutated patients had monoallelic mutations whereas two-thirds had multiple hits (multi-hit) consistent with biallelic targeting. Established associations with complex karyotype, few co-occurring mutations, high-risk presentation and poor outcomes were specific to multi-hit patients only. TP53 multi-hit state predicted risk of death and leukemic transformation independently of the Revised International Prognostic Scoring System (IPSS-R)11. Surprisingly, monoallelic patients did not differ from TP53 wild-type patients in outcomes and response to therapy. This study shows that consideration of TP53 allelic state is critical for diagnostic and prognostic precision in MDS as well as in future correlative studies of treatment response. Clinical sequencing across a large prospective cohort of patients with myelodysplasic syndrome uncovers distinct associations between the mono- and biallelic states of TP53 and clinical presentation
301 citations
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TL;DR: In this paper, color distinctiveness is explicitly incorporated into the design of saliency detection, which is called color saliency boosting, and is based on an analysis of the statistics of color image derivatives.
Abstract: The aim of salient feature detection is to find distinctive local events in images. Salient features are generally determined from the local differential structure of images. They focus on the shape-saliency of the local neighborhood. The majority of these detectors are luminance-based, which has the disadvantage that the distinctiveness of the local color information is completely ignored in determining salient image features. To fully exploit the possibilities of salient point detection in color images, color distinctiveness should be taken into account in addition to shape distinctiveness. In this paper, color distinctiveness is explicitly incorporated into the design of saliency detection. The algorithm, called color saliency boosting, is based on an analysis of the statistics of color image derivatives. Color saliency boosting is designed as a generic method easily adaptable to existing feature detectors. Results show that substantial improvements in information content are acquired by targeting color salient features.
301 citations
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TL;DR: The data reviewed in this article suggest that protons should no longer be considered simply as an unwanted by-product of anaerobic respiration that results from either an accumulation of inflammatory cells or a reduced oxygenated blood supply during ischaemia, but as a mediator that elicits a protective response with reflex cardiovascular and respiratory responses, and with the local release of sensory neuropeptides.
301 citations
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TL;DR: It is shown that, in the presence of phonon dissipation, the relevant energy scale for the spin relaxation is given by the lower-lying phonon modes interacting with the local spins, which opens a channel for spin reversal at energies lower than that set by the magnetic anisotropy.
Abstract: The use of single molecule magnets in mainstream electronics requires their magnetic moment to be stable over long times. One can achieve such a goal by designing compounds with spin-reversal barriers exceeding room temperature, namely with large uniaxial anisotropies. Such strategy, however, has been defeated by several recent experiments demonstrating under-barrier relaxation at high temperature, a behaviour today unexplained. Here we propose spin-phonon coupling to be responsible for such anomaly. With a combination of electronic structure theory and master equations we show that, in the presence of phonon dissipation, the relevant energy scale for the spin relaxation is given by the lower-lying phonon modes interacting with the local spins. These open a channel for spin reversal at energies lower than that set by the magnetic anisotropy, producing fast under-barrier spin relaxation. Our findings rationalize a significant body of experimental work and suggest a possible strategy for engineering room temperature single molecule magnets.
301 citations
Authors
Showing all 27699 results
Name | H-index | Papers | Citations |
---|---|---|---|
Charles A. Dinarello | 190 | 1058 | 139668 |
D. M. Strom | 176 | 3167 | 194314 |
Gregory Y.H. Lip | 169 | 3159 | 171742 |
Christopher M. Dobson | 150 | 1008 | 105475 |
Dirk Inzé | 149 | 647 | 74468 |
Thomas Hebbeker | 148 | 1984 | 114004 |
Marco Zanetti | 145 | 1439 | 104610 |
Richard B. Devereux | 144 | 962 | 116403 |
Gunther Roland | 141 | 1471 | 100681 |
Markus Klute | 139 | 1447 | 104196 |
Tariq Aziz | 138 | 1646 | 96586 |
Guido Tonelli | 138 | 1458 | 97248 |
Giorgio Trinchieri | 138 | 433 | 78028 |
Christof Roland | 137 | 1308 | 96632 |
Christoph Paus | 137 | 1585 | 100801 |