Institution
University of Florence
Education•Florence, Toscana, Italy•
About: University of Florence is a education organization based out in Florence, Toscana, Italy. It is known for research contribution in the topics: Population & Carbonic anhydrase. The organization has 27292 authors who have published 79599 publications receiving 2341684 citations. The organization is also known as: Università degli studi di Firenze & Universita degli studi di Firenze.
Papers published on a yearly basis
Papers
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University of Florida1, University of Montpellier2, University of Göttingen3, University of Melbourne4, University of Auvergne5, University of Sassari6, International Maize and Wheat Improvement Center7, Commonwealth Scientific and Industrial Research Organisation8, Goddard Institute for Space Studies9, Washington State University10, Pir Mehr Ali Shah Arid Agriculture University11, International Institute for Applied Systems Analysis12, Comenius University in Bratislava13, Michigan State University14, University of Florence15, James Hutton Institute16, CGIAR17, University of Leeds18, European Food Safety Authority19, Gembloux Agro-Bio Tech20, University of Bonn21, Spanish National Research Council22, University of Hohenheim23, Texas A&M University24, University of Maryland, College Park25, Aarhus University26, Nanjing Agricultural University27, Potsdam Institute for Climate Impact Research28, University of Copenhagen29, Indian Agricultural Research Institute30, SupAgro31, Lincoln University (New Zealand)32, Institut national de la recherche agronomique33, Rothamsted Research34, Wageningen University and Research Centre35, Chinese Academy of Sciences36, Beijing Normal University37, China Agricultural University38
TL;DR: A 32-multi-model ensemble is tested and applied to simulate global wheat yield and quality in a changing climate to potential benefits of elevated atmospheric CO2 concentration by 2050, likely to be negated by impacts from rising temperature and changes in rainfall, but with considerable disparities between regions.
Abstract: Wheat grain protein concentration is an important determinant of wheat quality for human nutrition that is often overlooked in efforts to improve crop production. We tested and applied a 32‐multi‐model ensemble to simulate global wheat yield and quality in a changing climate. Potential benefits of elevated atmospheric CO2 concentration by 2050 on global wheat grain and protein yield are likely to be negated by impacts from rising temperature and changes in rainfall, but with considerable disparities between regions. Grain and protein yields are expected to be lower and more variable in most low‐rainfall regions, with nitrogen availability limiting growth stimulus from elevated CO2. Introducing genotypes adapted to warmer temperatures (and also considering changes in CO2 and rainfall) could boost global wheat yield by 7% and protein yield by 2%, but grain protein concentration would be reduced by −1.1 percentage points, representing a relative change of −8.6%. Climate change adaptations that benefit grain yield are not always positive for grain quality, putting additional pressure on global wheat production.
286 citations
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Vardan Khachatryan1, Robin Erbacher2, C. A. Carrillo Montoya3, Chang-Seong Moon +2154 more•Institutions (149)
TL;DR: The first direct search for lepton-flavour-violating decays of the recently discovered Higgs boson (H) is described in this paper, where the search is performed in the H→μτ_e and H→mτ_h channels, where τeτe and τ_h are tau leptons reconstructed in the electronic and hadronic decay channels, respectively.
285 citations
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TL;DR: The frequency of the hereditary forms of pheochromocytoma/paraganglioma varies depending on the family history and the clinical presentation, and which genes should be screened first is suggested.
Abstract: Purpose: The aim of the study was to define the frequency of hereditary forms and the genotype/phenotype correlations in a large cohort of Italian patients with pheochromocytomas and/or functional or nonfunctional paragangliomas. Design: We examined 501 consecutive patients with pheochromocytomas and/or paragangliomas (secreting or nonsecreting). Complete medical and family histories, as well as the results of clinical, laboratory, and imaging studies, were recorded in a database. Patients were divided into different groups according to their family history, the presence of lesions outside adrenals/paraganglia considered syndromic for VHL disease, MEN2, and NF1, and the number and types of pheochromocytomas and/or paragangliomas. Germ-line mutations in known susceptibility genes were investigated by gene sequencing (VHL, RET, SDHB, SDHC, SDHD) or diagnosed according to phenotype (NF1). In 160 patients younger than 50 yr with a wild-type profile, multiplex ligation-dependent probe amplification assays were...
285 citations
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TL;DR: A protective role of RV is suggested in colon carcinogenesis with a mechanism involving changes in bax and p21 expression, which was higher in ACF than in normal mucosa of controls and of RV-treated animals.
Abstract: We investigated whether resveratrol (RV) affects azoxymethane (AOM)-induced colon carcinogenesis, by administering RV (200 microg/kg/day in drinking water) to male F344 rats for 100 days, beginning 10 days before carcinogen treatment (two weekly doses of 15 mg/kg AOM). Aberrant crypt foci (ACF) were isolated and proliferation, apoptosis and expression of the cell cycle genes bax and p21 were determined. RV significantly reduced the number of ACF/colon [25.7 +/- 3.6 (mean +/- SEM) versus 39.4 +/- 3.3 in controls; P < 0.01] and their multiplicity (2.7 +/- 0.3 versus 4.9 +/- 0.6 in controls; P < 0.01), and also abolished large ACF. In RV-treated rats, bax expression was enhanced in ACF but not in the surrounding mucosa. In both controls and RV-treated rats, proliferation was higher in ACF than in normal mucosa. p21 was expressed in ACF of controls and of RV-treated rats and in normal mucosa of controls, but was lost in normal mucosa of RV-treated animals. In conclusion, the results suggest a protective role of RV in colon carcinogenesis with a mechanism involving changes in bax and p21 expression.
284 citations
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TL;DR: SSNMR studies on well-ordered fibril samples of Aβ(40) with an additional N-terminal methionine provide high-resolution spectra which lead to an accurate structural model and revealed structural diversity in Aβ fibrils points to a complex picture of A β fibrillation.
Abstract: The amyloid fibrils of beta-amyloid (Aβ) peptides play important roles in the pathology of Alzheimer's disease Comprehensive solid-state NMR (SSNMR) structural studies on uniformly isotope-labeled Aβ assemblies have been hampered for a long time by sample heterogeneity and low spectral resolution In this work, SSNMR studies on well-ordered fibril samples of Aβ(40) with an additional N-terminal methionine provide high-resolution spectra which lead to an accurate structural model The fibrils studied here carry distinct structural features compared to previous reports The inter-β-strand contacts within the U-shaped β-strand-turn-β-strand motif are shifted, the N-terminal region adopts a β-conformation, and new inter-monomer contacts occur at the protofilament interface The revealed structural diversity in Aβ fibrils points to a complex picture of Aβ fibrillation
284 citations
Authors
Showing all 27699 results
Name | H-index | Papers | Citations |
---|---|---|---|
Charles A. Dinarello | 190 | 1058 | 139668 |
D. M. Strom | 176 | 3167 | 194314 |
Gregory Y.H. Lip | 169 | 3159 | 171742 |
Christopher M. Dobson | 150 | 1008 | 105475 |
Dirk Inzé | 149 | 647 | 74468 |
Thomas Hebbeker | 148 | 1984 | 114004 |
Marco Zanetti | 145 | 1439 | 104610 |
Richard B. Devereux | 144 | 962 | 116403 |
Gunther Roland | 141 | 1471 | 100681 |
Markus Klute | 139 | 1447 | 104196 |
Tariq Aziz | 138 | 1646 | 96586 |
Guido Tonelli | 138 | 1458 | 97248 |
Giorgio Trinchieri | 138 | 433 | 78028 |
Christof Roland | 137 | 1308 | 96632 |
Christoph Paus | 137 | 1585 | 100801 |