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Institution

University of Florence

EducationFlorence, Toscana, Italy
About: University of Florence is a education organization based out in Florence, Toscana, Italy. It is known for research contribution in the topics: Population & Carbonic anhydrase. The organization has 27292 authors who have published 79599 publications receiving 2341684 citations. The organization is also known as: Università degli studi di Firenze & Universita degli studi di Firenze.


Papers
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Journal ArticleDOI
04 Apr 2002-Nature
TL;DR: This finding provides added evidence that avoidance of protein aggregation is crucial for the preservation of biological function and suggests common features in the origins of this family of protein deposition diseases.
Abstract: A range of human degenerative conditions, including Alzheimer's disease, light-chain amyloidosis and the spongiform encephalopathies, is associated with the deposition in tissue of proteinaceous aggregates known as amyloid fibrils or plaques. It has been shown previously that fibrillar aggregates that are closely similar to those associated with clinical amyloidoses can be formed in vitro from proteins not connected with these diseases, including the SH3 domain from bovine phosphatidyl-inositol-3'-kinase and the amino-terminal domain of the Escherichia coli HypF protein. Here we show that species formed early in the aggregation of these non-disease-associated proteins can be inherently highly cytotoxic. This finding provides added evidence that avoidance of protein aggregation is crucial for the preservation of biological function and suggests common features in the origins of this family of protein deposition diseases.

2,456 citations

Journal ArticleDOI
TL;DR: The fundamental concepts needed to understand quantum size effects in molecular magnets are reviewed and critically report what has been done in the field to date are critically reported.
Abstract: Molecules comprising a large number of coupled paramagnetic centers are attracting much interest because they may show properties which are intermediate between those of simple paramagnets and classical bulk magnets and provide unambiguous evidence of quantum size effects in magnets. To date, two cluster families, usually referred to as Mn12 and Fe8, have been used to test theories. However, it is reasonable to predict that other classes of molecules will be discovered which have similar or superior properties. To do this it is necessary that synthetic chemists have a good understanding of the correlation between the structure and properties of the molecules, for this it is necessary that concepts such as quantum tunneling, quantum coherence, quantum oscillations are understood. The goal of this article is to review the fundamental concepts needed to understand quantum size effects in molecular magnets and to critically report what has been done in the field to date.

2,452 citations

Journal ArticleDOI
TL;DR: Small vessel disease has an important role in cerebrovascular disease and is a leading cause of cognitive decline and functional loss in the elderly and should be a main target for preventive and treatment strategies, but all types of presentation and complications should be taken into account.
Abstract: Summary The term cerebral small vessel disease refers to a group of pathological processes with various aetiologies that affect the small arteries, arterioles, venules, and capillaries of the brain. Age-related and hypertension-related small vessel diseases and cerebral amyloid angiopathy are the most common forms. The consequences of small vessel disease on the brain parenchyma are mainly lesions located in the subcortical structures such as lacunar infarcts, white matter lesions, large haemorrhages, and microbleeds. Because lacunar infarcts and white matter lesions are easily detected by neuroimaging, whereas small vessels are not, the term small vessel disease is frequently used to describe the parenchyma lesions rather than the underlying small vessel alterations. This classification, however, restricts the definition of small vessel disease to ischaemic lesions and might be misleading. Small vessel disease has an important role in cerebrovascular disease and is a leading cause of cognitive decline and functional loss in the elderly. Small vessel disease should be a main target for preventive and treatment strategies, but all types of presentation and complications should be taken into account.

2,330 citations

Journal ArticleDOI
02 Apr 2009-Nature
TL;DR: It is found that the positron fraction increases sharply over much of that range, in a way that appears to be completely inconsistent with secondary sources, and is concluded that a primary source, be it an astrophysical object or dark matter annihilation, is necessary.
Abstract: Antiparticles account for a small fraction of cosmic rays and are known to be produced in interactions between cosmic-ray nuclei and atoms in the interstellar medium(1), which is referred to as a ' ...

2,287 citations

Journal ArticleDOI
A. A. Alves, L. M. Andrade Filho1, A. F. Barbosa, Ignacio Bediaga  +886 moreInstitutions (64)
TL;DR: The LHCb experiment is dedicated to precision measurements of CP violation and rare decays of B hadrons at the Large Hadron Collider (LHC) at CERN (Geneva).
Abstract: The LHCb experiment is dedicated to precision measurements of CP violation and rare decays of B hadrons at the Large Hadron Collider (LHC) at CERN (Geneva). The initial configuration and expected performance of the detector and associated systems, as established by test beam measurements and simulation studies, is described.

2,286 citations


Authors

Showing all 27699 results

NameH-indexPapersCitations
Charles A. Dinarello1901058139668
D. M. Strom1763167194314
Gregory Y.H. Lip1693159171742
Christopher M. Dobson1501008105475
Dirk Inzé14964774468
Thomas Hebbeker1481984114004
Marco Zanetti1451439104610
Richard B. Devereux144962116403
Gunther Roland1411471100681
Markus Klute1391447104196
Tariq Aziz138164696586
Guido Tonelli138145897248
Giorgio Trinchieri13843378028
Christof Roland137130896632
Christoph Paus1371585100801
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023244
2022631
20215,298
20205,251
20194,652
20184,147