University of Fribourg

About: University of Fribourg is a education organization based out in Fribourg, Freiburg, Switzerland. It is known for research contribution in the topics: Population & Glacier. The organization has 6040 authors who have published 14975 publications receiving 542500 citations. The organization is also known as: UNIFR & Universität Freiburg.

A laser-pumped magnetometer for the mapping of human cardiomagnetic fields

Abstract: Magnetic fields produced by biological organisms contain valuable information on the underlying physiological processes and their pathologies. Currently, superconducting detectors cooled far below room temperature are required to measure these generally weak biomagnetic signals. We have developed a sensitive laser magnetometer based on optical pumping of cesium atoms that makes it possible to map the magnetic field produced by the beating human heart. A gradiometer formed by two identical sensors greatly reduces the influence of external stray magnetic fields. The magnetometer operates at room temperature and therefore opens the way to affordable and convenient monitoring of biomagnetic fields in research and medical diagnostics.

CCS-TA: quality-guaranteed online task allocation in compressive crowdsensing

Abstract: Data quality and budget are two primary concerns in urban-scale mobile crowdsensing applications. In this paper, we leverage the spatial and temporal correlation among the data sensed in different sub-areas to significantly reduce the required number of sensing tasks allocated (corresponding to budget), yet ensuring the data quality. Specifically, we propose a novel framework called CCS-TA, combining the state-of-the-art compressive sensing, Bayesian inference, and active learning techniques, to dynamically select a minimum number of sub-areas for sensing task allocation in each sensing cycle, while deducing the missing data of unallocated sub-areas under a probabilistic data accuracy guarantee. Evaluations on real-life temperature and air quality monitoring datasets show the effectiveness of CCS-TA. In the case of temperature monitoring, CCS-TA allocates 18.0-26.5% fewer tasks than baseline approaches, allocating tasks to only 15.5% of the sub-areas on average while keeping overall sensing error below 0.25°C in 95% of the cycles.

Pulsatile shear and Gja5 modulate arterial identity and remodeling events during flow-driven arteriogenesis

Abstract: In the developing chicken embryo yolk sac vasculature, the expression of arterial identity genes requires arterial hemodynamic conditions. We hypothesize that arterial flow must provide a unique signal that is relevant for supporting arterial identity gene expression and is absent in veins. We analyzed factors related to flow, pressure and oxygenation in the chicken embryo vitelline vasculature in vivo. The best discrimination between arteries and veins was obtained by calculating the maximal pulsatile increase in shear rate relative to the time-averaged shear rate in the same vessel: the relative pulse slope index (RPSI). RPSI was significantly higher in arteries than veins. Arterial endothelial cells exposed to pulsatile shear in vitro augmented arterial marker expression as compared with exposure to constant shear. The expression of Gja5 correlated with arterial flow patterns: the redistribution of arterial flow provoked by vitelline artery ligation resulted in flow-driven collateral arterial network formation and was associated with increased expression of Gja5. In situ hybridization in normal and ligation embryos confirmed that Gja5 expression is confined to arteries and regulated by flow. In mice, Gja5 (connexin 40) was also expressed in arteries. In the adult, increased flow drives arteriogenesis and the formation of collateral arterial networks in peripheral occlusive diseases. Genetic ablation of Gja5 function in mice resulted in reduced arteriogenesis in two occlusion models. We conclude that pulsatile shear patterns may be central for supporting arterial identity, and that arterial Gja5 expression plays a functional role in flow-driven arteriogenesis.

Pick-a-crowd: tell me what you like, and i'll tell you what to do

Abstract: Crowdsourcing allows to build hybrid online platforms that combine scalable information systems with the power of human intelligence to complete tasks that are difficult to tackle for current algorithms. Examples include hybrid database systems that use the crowd to fill missing values or to sort items according to subjective dimensions such as picture attractiveness. Current approaches to Crowdsourcing adopt a pull methodology where tasks are published on specialized Web platforms where workers can pick their preferred tasks on a first-come-first-served basis. While this approach has many advantages, such as simplicity and short completion times, it does not guarantee that the task is performed by the most suitable worker. In this paper, we propose and extensively evaluate a different Crowdsourcing approach based on a push methodology. Our proposed system carefully selects which workers should perform a given task based on worker profiles extracted from social networks. Workers and tasks are automatically matched using an underlying categorization structure that exploits entities extracted from the task descriptions on one hand, and categories liked by the user on social platforms on the other hand. We experimentally evaluate our approach on tasks of varying complexity and show that our push methodology consistently yield better results than usual pull strategies.

HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα.

Abstract: The selective removal of undesired or damaged mitochondria by autophagy, known as mitophagy, is crucial for cellular homoeostasis, and prevents tumour diffusion, neurodegeneration and ageing The pro-autophagic molecule AMBRA1 (autophagy/beclin-1 regulator-1) has been defined as a novel regulator of mitophagy in both PINK1/PARKIN-dependent and -independent systems Here, we identified the E3 ubiquitin ligase HUWE1 as a key inducing factor in AMBRA1-mediated mitophagy, a process that takes place independently of the main mitophagy receptors Furthermore, we show that mitophagy function of AMBRA1 is post-translationally controlled, upon HUWE1 activity, by a positive phosphorylation on its serine 1014 This modification is mediated by the IKKα kinase and induces structural changes in AMBRA1, thus promoting its interaction with LC3/GABARAP (mATG8) proteins and its mitophagic activity Altogether, these results demonstrate that AMBRA1 regulates mitophagy through a novel pathway, in which HUWE1 and IKKα are key factors, shedding new lights on the regulation of mitochondrial quality control and homoeostasis in mammalian cells