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Institution

University of Fribourg

EducationFribourg, Freiburg, Switzerland
About: University of Fribourg is a education organization based out in Fribourg, Freiburg, Switzerland. It is known for research contribution in the topics: Population & Glacier. The organization has 6040 authors who have published 14975 publications receiving 542500 citations. The organization is also known as: UNIFR & Universität Freiburg.


Papers
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Journal ArticleDOI
TL;DR: The existence of short-lived proteins that may serve the role of caspase-independent effectors of apoptosis and attractive targets of the death-protective action of Bcl-2 are suggested.

122 citations

Journal ArticleDOI
TL;DR: The study demonstrates that mice are not explicitly nocturnal in this natural environment and demonstrates that the activity of mice, while strictly nocturn in the laboratory, may be partially or completely diurnal in the field and allows assessment of natural selection on specific alleles on a day-today basis.
Abstract: Da ily patterns of animal behavior are potentially of vast functional importance. Fitness benefits have been identified in nature by the association between individual timing and survival or by the fate of individuals after experi- mental deletion of their circadian pacemaker. The recent advances in unraveling the molecular basis of circadian timing enable new approaches to natural selection on timing. The investigators report on the effect and fate of the mutant Per2 Brdm1 allele in 4 replicate populations of house mice in a seminatural outside environment over 2 years. This allele is known to compromise circadian organization and entrain- ment and to cause multiple physiological disturbances. Mice (N = 250) bred from Per2 Brdm1 heterozygotes were implanted subcutaneously with transponders and released in approximately Mendelian ratios in four 400 m 2 pens. An electronic system stored the times of all visits to feeders of each individual. The study first demonstrates that mice are not explicitly nocturnal in this natural environment. Feeding activity was predominantly and sometimes exclusively diurnal and spread nearly equally over day and night under the protective snow cover in winter. The effect of Per2 Brdm1 on activity timing is negligible compared to seasonal changes in all genotypes. Second, the Per2 Brdm1 allele did not have persistent negative effects on fitness. In the first year, the allele gradually became less frequent by reducing survival. New cohorts captured had the same Per2 Brdm1 frequency as the survivors from previous cohorts, consistent with an absence of an effect on reproduction. In the second year, the allele recovered to about its initial frequency (0.54). These changes in selective advantage were primarily due to female mice, as females lived longer and the sex ratio dropped to about 25% males in the population. While it is unknown which selective advantage led to the recovery, the results caution against inferences from laboratory experiments on fitness consequences in the natural environment. It also demonstrates that the activity of mice, while strictly nocturnal

122 citations

Journal ArticleDOI
TL;DR: The inventory reveals that many hormones are transported by members of distinct transporter classes, with an apparent dominance of the ATP-binding cassette (ABC) family and of the Nitrate transport1/Peptide transporter family (NPF).
Abstract: Hormone transporters are crucial for plant hormone action, which is underlined by severe developmental and physiological impacts caused by their loss-of-function mutations. Here, we summarize recent knowledge on the individual roles of plant hormone transporters in local and long-distance transport. Our inventory reveals that many hormones are transported by members of distinct transporter classes, with an apparent dominance of the ATP-binding cassette (ABC) family and of the Nitrate transport1/Peptide transporter family (NPF). The current need to explore further hormone transporter regulation, their functional interaction, transport directionalities, and substrate specificities is briefly reviewed.

121 citations

Journal ArticleDOI
TL;DR: This review summarizes the recent developments of computational network biology, first introducing various types of biological networks and network structural properties, and then reviewing the network-based approaches, ranging from some network metrics to the complicated machine-learning methods.

121 citations

Journal ArticleDOI
TL;DR: In this paper, the absorption spectra of neutral pentacene (C22H14) and its radical cation (C 22H14+) and anion isolated in solid Ne, Ar and Kr have been measured from the ultraviolet to the near-infrared.
Abstract: The absorption spectra of neutral pentacene (C22H14) and its radical cation (C22H14+) and anion (C22H14-) isolated in solid Ne, Ar, and Kr have been measured from the ultraviolet to the near-infrared. The associated vibronic band systems and their spectroscopic assignments are discussed together with the physical and chemical conditions governing molecular anion production in matrices doped with alkali metal (Na or K). TD-DFT calculations were carried out to assist in the assignments for the measured spectral features of the pentacene ions.

121 citations


Authors

Showing all 6204 results

NameH-indexPapersCitations
Jens Nielsen1491752104005
Sw. Banerjee1461906124364
Hans Peter Beck143113491858
Patrice Nordmann12779067031
Abraham Z. Snyder12532991997
Csaba Szabó12395861791
Robert Edwards12177574552
Laurent Poirel11762153680
Thomas Münzel116105557716
David G. Amaral11230249094
F. Blanc107151458418
Markus Stoffel10262050796
Vincenzo Balzani10147645722
Enrico Bertini9986538167
Sandeep Kumar94156338652
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202367
2022348
20211,110
20201,112
2019966
2018924