Institution
University of Fribourg
Education•Fribourg, Freiburg, Switzerland•
About: University of Fribourg is a education organization based out in Fribourg, Freiburg, Switzerland. It is known for research contribution in the topics: Population & Glacier. The organization has 6040 authors who have published 14975 publications receiving 542500 citations. The organization is also known as: UNIFR & Universität Freiburg.
Topics: Population, Glacier, Excited state, Hubbard model, Scattering
Papers published on a yearly basis
Papers
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Karolinska Institutet1, University of Fribourg2, Northwestern University3, University of Zurich4, University of Queensland5, University of Texas Southwestern Medical Center6, Laboratory of Molecular Biology7, University of Würzburg8, Cincinnati Children's Hospital Medical Center9, French Institute of Health and Medical Research10, University of Manchester11, Max Planck Society12, Leiden University Medical Center13, Howard Hughes Medical Institute14, Rockefeller University15
TL;DR: There is emerging evidence showing that some drugs are more effective at nighttime than daytime, whereas for others it is the opposite, which suggests that the biology of the target cell will determine how an organ will respond to a drug at a specific time of the day, thus modulating pharmacodynamics.
215 citations
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University of Hohenheim1, Karlsruhe Institute of Technology2, German Aerospace Center3, Leibniz Association4, MeteoSwiss5, University of Leeds6, Delft University of Technology7, University of Montpellier8, University of Cologne9, University of Potsdam10, University of Vienna11, University of Bayreuth12, Centre national de la recherche scientifique13, University of Fribourg14, Deutscher Wetterdienst15, EUMETSAT16, Pacific Northwest National Laboratory17, University of Hamburg18, University of Toulouse19, University of Innsbruck20, University of Wisconsin-Madison21, Blaise Pascal University22, National Center for Atmospheric Research23, ETH Zurich24
TL;DR: The COPS field phase was performed from 1 June to 31 August 2007 in a low-mountain area in southwestern Germany/eastern France covering the Vosges mountains, the Rhine valley and the Black Forest mountains.
Abstract: Within the framework of the international field campaign COPS (Convective and Orographically induced Precipitation Study), a large suite of state-of-the-art meteorological instrumentation was operated, partially combined for the first time. This includes networks of in situ and remote-sensing systems such as the Global Positioning System as well as a synergy of multi-wavelength passive and active remote-sensing instruments such as advanced radar and lidar systems. The COPS field phase was performed from 01 June to 31 August 2007 in a low-mountain area in southwestern Germany/eastern France covering the Vosges mountains, the Rhine valley and the Black Forest mountains. The collected dataset covers the entire evolution of convective precipitation events in complex terrain from their initiation, to their development and mature phase until their decay. Eighteen Intensive Observations Periods with 37 operation days and eight additional Special Observations Periods were performed, providing a comprehensive dataset covering different forcing conditions. In this article, an overview of the COPS scientific strategy, the field phase, and its first accomplishments is given. Highlights of the campaign are illustrated with several measurement examples. It is demonstrated that COPS research provides new insight into key processes leading to convection initiation and to the modification of precipitation by orography, in the improvement of quantitative precipitation forecasting by the assimilation of new observations, and in the performance of ensembles of convection-permitting models in complex terrain.
215 citations
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TL;DR: This review discusses seventeen CDK inhibitors and their use in cancer research or therapy and should help researchers to decide which inhibitor is best suited for the specific purpose of their research.
Abstract: Chemical compounds that interfere with an enzymatic function of kinases are useful for gaining insight into the complicated biochemical processes in mammalian cells. Cyclin-dependent kinases (CDK) play an essential role in the control of the cell cycle and/or proliferation. These kinases as well as their regulators are frequently deregulated in different human tumors. Aberrations in CDK activity have also been observed in viral infections, Alzheimer's, Parkinson's diseases, ischemia and some proliferative disorders. This led to an intensive search for small-molecule CDK inhibitors not only for research purposes, but also for therapeutic applications. Here, we discuss seventeen CDK inhibitors and their use in cancer research or therapy. This review should help researchers to decide which inhibitor is best suited for the specific purpose of their research. For this purpose, the targets, commercial availability and IC(50) values are provided for each inhibitor. The review will also provide an overview of the clinical studies performed with some of these inhibitors.
215 citations
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TL;DR: The calcium-binding protein parvalbumin (PV) occurs at high concentrations in fast-contracting vertebrate muscle fibers and its putative role in facilitating the rapid relaxation of mammalian fast-twi...
Abstract: The calcium-binding protein parvalbumin (PV) occurs at high concentrations in fast-contracting vertebrate muscle fibers. Its putative role in facilitating the rapid relaxation of mammalian fast-twi...
214 citations
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TL;DR: The present anatomical labeling study is in agreement with the conclusion of Schell and Strick (1984) that the SMA, especially its central portion, is an important target of basal ganglia outflow via the thalamic relay VLo.
Abstract: The interrelationship of medial area 6 (supplementary motor area) with the thalamus was investigated by means of anterograde and retrograde tracing methods. Nine monkeys were prepared for autoradiography or histochemistry with the marker HRP conjugated to the lectin wheat germ agglutinin. Three of the monkeys received injections into the precentral cortex for comparison. Previous observations were confirmed that the thalamic relays to the motor areas are organized as crescent-shaped lamellae which transgress cytoarchitectonic boundaries. The thalamic VA-VL complex receiving fibres from areas 4 and medial area 6 also sends fibres to these same areas. The thalamic relay to medial area 6 comprised the following subdivisions: VLo, VLc, area X of Olszewski, VLm and, to a smaller extent VA. Labeling (mostly anterograde only) was also prominent in some thalamic compartments outside the 'motor' thalamus: R, CL, CM-Pf, MD, LP, PULo. It was noted that rostral and caudal injections into the medial area 6 resulted in different thalamic labeling: The rostral portion was found to be related mainly with VApc, area X and VLc, the central portion with VLo, and the caudal portion with VLc/VLo. This structural inhomogeneity may reflect also a functional rostro-caudal differentiation of the medial area 6. The thalamic territory projecting to the precentral cortex is separate from the above relay and includes principally VPLo. The present anatomical labeling study is in agreement with the conclusion of Schell and Strick (1984) that the SMA, especially its central portion, is an important target of basal ganglia outflow via the thalamic relay VLo. In addition consistent labeling was also found in thalamic subdivisions (area X, VLc) which had been found to receive cerebellar fibres.
214 citations
Authors
Showing all 6204 results
Name | H-index | Papers | Citations |
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Jens Nielsen | 149 | 1752 | 104005 |
Sw. Banerjee | 146 | 1906 | 124364 |
Hans Peter Beck | 143 | 1134 | 91858 |
Patrice Nordmann | 127 | 790 | 67031 |
Abraham Z. Snyder | 125 | 329 | 91997 |
Csaba Szabó | 123 | 958 | 61791 |
Robert Edwards | 121 | 775 | 74552 |
Laurent Poirel | 117 | 621 | 53680 |
Thomas Münzel | 116 | 1055 | 57716 |
David G. Amaral | 112 | 302 | 49094 |
F. Blanc | 107 | 1514 | 58418 |
Markus Stoffel | 102 | 620 | 50796 |
Vincenzo Balzani | 101 | 476 | 45722 |
Enrico Bertini | 99 | 865 | 38167 |
Sandeep Kumar | 94 | 1563 | 38652 |