University of Fukui

About: University of Fukui is a education organization based out in Fukui-shi, Japan. It is known for research contribution in the topics: Gyrotron & Terahertz radiation. The organization has 4913 authors who have published 8971 publications receiving 129701 citations. The organization is also known as: Fukui Daigaku.

MWMOTE--Majority Weighted Minority Oversampling Technique for Imbalanced Data Set Learning

Abstract: Imbalanced learning problems contain an unequal distribution of data samples among different classes and pose a challenge to any classifier as it becomes hard to learn the minority class samples. Synthetic oversampling methods address this problem by generating the synthetic minority class samples to balance the distribution between the samples of the majority and minority classes. This paper identifies that most of the existing oversampling methods may generate the wrong synthetic minority samples in some scenarios and make learning tasks harder. To this end, a new method, called Majority Weighted Minority Oversampling TEchnique (MWMOTE), is presented for efficiently handling imbalanced learning problems. MWMOTE first identifies the hard-to-learn informative minority class samples and assigns them weights according to their euclidean distance from the nearest majority class samples. It then generates the synthetic samples from the weighted informative minority class samples using a clustering approach. This is done in such a way that all the generated samples lie inside some minority class cluster. MWMOTE has been evaluated extensively on four artificial and 20 real-world data sets. The simulation results show that our method is better than or comparable with some other existing methods in terms of various assessment metrics, such as geometric mean (G-mean) and area under the receiver operating curve (ROC), usually known as area under curve (AUC).

Kirsten ras mutations in patients with colorectal cancer: the ‘RASCAL II’ study

Abstract: Researchers worldwide with information about the Kirsten ras (Ki-ras) tumour genotype and outcome of patients with colorectal cancer were invited to provide that data in a schematized format for inclusion in a collaborative database called RASCAL (The Kirsten ras incolorectal-cancer collaborative group). Our results from 2721 such patients have been presented previously and for the first time in any common cancer, showed conclusively that different gene mutations have different impacts on outcome, even when the mutations occur at the same site on the genome. To explore the effect of Ki-ras mutations at different stages of colorectal cancer, more patients were recruited to the database, which was reanalysed when information on 4268 patients from 42 centres in 21 countries had been entered. After predetermined exclusion criteria were applied, data on 3439 patients were entered into a multivariate analysis. This found that of the 12 possible mutations on codons 12 and 13 of Kirsten ras, only one mutation on codon 12, glycine to valine, found in 8.6% of all patients, had a statistically significant impact on failure-free survival (P=0.004, HR 1.3) and overall survival (P=0.008, HR 1.29). This mutation appeared to have a greater impact on outcome in Dukes' C cancers (failure-free survival, P=0.008, HR 1.5, overall survival P=0.02, HR 1.45) than in Dukes' B tumours (failure-free survival, P=0.46, HR 1.12, overall survival P=0.36, HR 1.15). Ki-ras mutations may occur early in the development of pre-cancerous adenomas in the colon and rectum. However, this collaborative study suggests that not only is the presence of a codon 12 glycine to valine mutation important for cancer progression but also that it may predispose to more aggressive biological behaviour in patients with advanced colorectal cancer. ⌐ 2001 Cancer Research Campaign.

Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5

Abstract: The intestinal cell types responsible for defense against pathogenic organisms remain incompletely characterized. Here we identify a subset of CD11c(hi)CD11b(hi) lamina propria dendritic cells (LPDCs) that expressed Toll-like receptor 5 (TLR5) in the small intestine. When stimulated by the TLR5 ligand flagellin, TLR5(+) LPDCs induced the differentiation of naive B cells into immunoglobulin A-producing plasma cells by a mechanism independent of gut-associated lymphoid tissue. In addition, by a mechanism dependent on TLR5 stimulation, these LPDCs promoted the differentiation of antigen-specific interleukin 17-producing T helper cells and type 1 T helper cells. Unlike spleen DCs, the LPDCs specifically produced retinoic acid, which, in a dose-dependent way, supported the generation and retention of immunoglobulin A-producing cells in the lamina propria and positively regulated the differentiation interleukin 17-producing T helper cells. Our findings demonstrate unique properties of LPDCs and the importance of TLR5 for adaptive immunity in the intestine.

Gilteritinib or chemotherapy for relapsed or refractory FLT3-mutated AML

Abstract: Background Patients with relapsed or refractory acute myeloid leukemia (AML) with mutations in the FMS-like tyrosine kinase 3 gene (FLT3) infrequently have a response to salvage chemothera...