University of Geneva

About: University of Geneva is a education organization based out in Geneva, Switzerland. It is known for research contribution in the topics: Population & Galaxy. The organization has 26887 authors who have published 65265 publications receiving 2931373 citations. The organization is also known as: Geneva University & Universite de Geneve.

Multimodal Emotion Recognition in Response to Videos

Abstract: This paper presents a user-independent emotion recognition method with the goal of recovering affective tags for videos using electroencephalogram (EEG), pupillary response and gaze distance. We first selected 20 video clips with extrinsic emotional content from movies and online resources. Then, EEG responses and eye gaze data were recorded from 24 participants while watching emotional video clips. Ground truth was defined based on the median arousal and valence scores given to clips in a preliminary study using an online questionnaire. Based on the participants' responses, three classes for each dimension were defined. The arousal classes were calm, medium aroused, and activated and the valence classes were unpleasant, neutral, and pleasant. One of the three affective labels of either valence or arousal was determined by classification of bodily responses. A one-participant-out cross validation was employed to investigate the classification performance in a user-independent approach. The best classification accuracies of 68.5 percent for three labels of valence and 76.4 percent for three labels of arousal were obtained using a modality fusion strategy and a support vector machine. The results over a population of 24 participants demonstrate that user-independent emotion recognition can outperform individual self-reports for arousal assessments and do not underperform for valence assessments.

Temporal colinearity and the phylotypic progression: a basis for the stability of a vertebrate Bauplan and the evolution of morphologies through heterochrony

Abstract: Vertebrate Hox genes are essential for the proper organization of the body plan during development. Inactivation of these genes usually leads to important alterations, or transformations, in the identities of the affected developing structures. Hox genes are activated in a progressive temporal sequence which is colinear with the position of these genes on their respective complexes, so that 'anterior' genes are activated earlier than 'posterior' ones (temporal colinearity). Here, an hypothesis is considered in which the correct timing of activation of this gene family is necessary in order to properly establish the various expression domains. Slight modifications in the respective times of gene activation (heterochronies) may shift expression domains along the rostrocaudal axis and thus induce concurrent changes in morphologies. It is further argued that temporal colinearity only occurs in cells with high mitotic rates, which results in a strong linkage between patterning and growth control and makes the patterning process unidirectional, from anterior, proximal and early, to posterior, distal and late, a model referred to as the 'Einbahnstrasse'. While the nature of the mechanism(s) behind temporal and spatial colinearities is unknown, it is proposed that such a mechanism relies on meta-cis interactions, that is it may necessitate gene contiguity. Such a mechanism would be based on DNA-specific, rather than gene-specific, features such as chromatin configurations or DNA replication. The existence of such a meta-cis mechanism would explain the extraoridinary conservation of this genetic system during evolution as its basic properties would be linked to that of the genetic material itself.(ABSTRACT TRUNCATED AT 250 WORDS)

Gaia Data Release 2. Kinematics of globular clusters and dwarf galaxies around the Milky Way

Abstract: Context. Aims: The goal of this paper is to demonstrate the outstanding quality of the second data release of the Gaia mission and its power for constraining many different aspects of the dynamics of the satellites of the Milky Way. We focus here on determining the proper motions of 75 Galactic globular clusters, nine dwarf spheroidal galaxies, one ultra-faint system, and the Large and Small Magellanic Clouds. Methods: Using data extracted from the Gaia archive, we derived the proper motions and parallaxes for these systems, as well as their uncertainties. We demonstrate that the errors, statistical and systematic, are relatively well understood. We integrated the orbits of these objects in three different Galactic potentials, and characterised their properties. We present the derived proper motions, space velocities, and characteristic orbital parameters in various tables to facilitate their use by the astronomical community. Results: Our limited and straightforward analyses have allowed us for example to (i) determine absolute and very precise proper motions for globular clusters; (ii) detect clear rotation signatures in the proper motions of at least five globular clusters; (iii) show that the satellites of the Milky Way are all on high-inclination orbits, but that they do not share a single plane of motion; (iv) derive a lower limit for the mass of the Milky Way of 9.1-2.6+6.2 × 1011 M⊙ based on the assumption that the Leo I dwarf spheroidal is bound; (v) derive a rotation curve for the Large Magellanic Cloud based solely on proper motions that is competitive with line-of-sight velocity curves, now using many orders of magnitude more sources; and (vi) unveil the dynamical effect of the bar on the motions of stars in the Large Magellanic Cloud. Conclusions: All these results highlight the incredible power of the Gaia astrometric mission, and in particular of its second data release.

Improving adherence to hand hygiene practice: a multidisciplinary approach.

Abstract: Hand hygiene prevents cross-infection in hospitals, but health-care workers' adherence to guidelines is poor. Easy, timely access to both hand hygiene and skin protection is necessary for satisfactory hand hygiene behavior. Alcohol- based hand rubs may be better than traditional handwashing as they require less time, act faster, are less irritating, and contribute to sustained improvement in compliance associated with decreased infection rates. This article reviews barriers to appropriate hand hygiene and risk factors for noncompliance and proposes strategies for promoting hand hygiene.

Mitochondrial bioenergetics and structural network organization

Abstract: Mitochondria form a dynamic network, and it remains unclear how the alternate configurations interact with bioenergetics properties. The metabolic signals that link mitochondrial structure to its functional states have not been fully characterized. In this report, we analyze the bidirectional relationships between mitochondrial morphology and function in living human cells. First, we determined the effect of mitochondrial fission on energy production by using small interfering RNA (siRNA) targeting DRP1, which revealed the importance of membrane fluidity on the control of bioenergetics. Second, we followed the effect of rotenone, a specific inhibitor of respiratory chain complex I, which causes large structural perturbations, once a threshold was reached. Last, we followed changes in the mitochondrial network configuration in human cells that had been treated with modulators of oxidative phosphorylation, and in fibroblasts from two patients with mitochondrial disease where the respiratory rate, DeltaPsi and the generation of reactive oxygen species (ROS) were measured. Our data demonstrate that the relationship between mitochondrial network organization and bioenergetics is bidirectional, and we provide a model for analyzing the metabolic signals involved in this crosstalk.