Institution
University of Geneva
Education•Geneva, Switzerland•
About: University of Geneva is a education organization based out in Geneva, Switzerland. It is known for research contribution in the topics: Population & Galaxy. The organization has 26887 authors who have published 65265 publications receiving 2931373 citations. The organization is also known as: Geneva University & Universite de Geneve.
Topics: Population, Galaxy, Planet, Stars, Context (language use)
Papers published on a yearly basis
Papers
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TL;DR: The identification of a Y‐box transcription factor, ZONAB, that binds to the SH3 domain of ZO‐1, a submembrane protein of tight junctions indicates that tightjunctions directly participate in the control of gene expression and suggest that they function in the regulation of epithelial cell differentiation.
Abstract: Epithelial tight junctions regulate paracellular diffusion and restrict the intermixing of apical and basolateral plasma membrane components. We now identify a Y-box transcription factor, ZONAB (ZO-1-associated nucleic acid-binding protein), that binds to the SH3 domain of ZO-1, a submembrane protein of tight junctions. ZONAB localizes to the nucleus and at tight junctions, and binds to sequences of specific promoters containing an inverted CCAAT box. In reporter assays, ZONAB and ZO-1 functionally interact in the regulation of the ErbB-2 promoter in a cell density-dependent manner. In stably transfected overexpressing cells, ZO-1 and ZONAB control expression of endogenous ErbB-2 and function in the regulation of paracellular permeability. These data indicate that tight junctions directly participate in the control of gene expression and suggest that they function in the regulation of epithelial cell differentiation.
455 citations
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TL;DR: In this paper, the authors reported the observation of a state consistent with X(3872) decaying into J/ψπ+π-decomposition, where the observed width was consistent with the detector resolution and the results were found to be converging well with the measurements by the Belle Collaboration using b± decays.
Abstract: The observation of a state consistent with X(3872) decaying into J/ψπ+π- was reported. The X(3872) mass was measured to be 3871.3±0.7(stat)±0.4(syst)MeV/c2 from a sample of 730±90 candidates. The observed width was consistent with the detector resolution. The results were found to be converging well with the measurements by the Belle Collaboration using b± decays.
455 citations
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University of New South Wales1, University of Pennsylvania2, New England Baptist Hospital3, Keio University4, Autonomous University of Barcelona5, University of Geneva6, New York University7, University of North Carolina at Chapel Hill8, Duke University9, University Hospitals of Leicester NHS Trust10, Kurume University11, University of Barcelona12, Michigan State University13, University of Groningen14, Gifu University15, Case Western Reserve University16, Rabin Medical Center17, University of Texas Southwestern Medical Center18, Hokkaido University19, University of Lübeck20, Veterans Health Administration21
TL;DR: This consensus statement from the International Pemphigus Committee represents 2 years of collaborative efforts to attain mutually acceptable common definitions for pemphIGus and should assist in development of consistent reporting of outcomes in future studies.
Abstract: Our scientific knowledge of pemphigus has dramatically progressed in recent years. However, despite the availability of various therapeutic options for the treatment of inflammatory diseases, only a few multicenter controlled trials have helped to define effective therapies in pemphigus. A major obstacle in comparing therapeutic outcomes between centers is the lack of generally accepted definitions and measurements for the clinical evaluation of patients with pemphigus. Common terms and end points of pemphigus are needed so that experts in the field can accurately measure and assess disease extent, activity, severity, and therapeutic response, and thus facilitate and advance clinical trials. This consensus statement from the International Pemphigus Committee represents 2 years of collaborative efforts to attain mutually acceptable common definitions for pemphigus. These should assist in development of consistent reporting of outcomes in future studies.
455 citations
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TL;DR: Drought and re-watering had little effect on the maximum quantum yield of primary photochemistry φPo(=FV/FM), but changes in respectively the L and K-bands of the fluorescence transients OJIP were shown to have predictive value with respect to the vitality of leaves and the tolerance of the varieties to drought stress.
455 citations
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University of Bern1, Oeschger Centre for Climate Change Research2, University of Adelaide3, University of Reading4, California Institute of Technology5, Columbia University6, Lamont–Doherty Earth Observatory7, VU University Amsterdam8, University of California, Irvine9, École Normale Supérieure10, École des ponts ParisTech11, Max Planck Society12, Leipzig University13, University of Graz14, University of Lisbon15, University of New South Wales16, Vrije Universiteit Brussel17, University of Geneva18
TL;DR: A typology of compound events is proposed, distinguishing events that are preconditioned, multivariate, temporally compounding and spatially compounding, and suggests analytical and modelling approaches to aid in their investigation.
Abstract: Compound weather and climate events describe combinations of multiple climate drivers and/or hazards that contribute to societal or environmental risk. Although many climate-related disasters are caused by compound events, the understanding, analysis, quantification and prediction of such events is still in its infancy. In this Review, we propose a typology of compound events and suggest analytical and modelling approaches to aid in their investigation. We organize the highly diverse compound event types according to four themes: preconditioned, where a weather-driven or climate-driven precondition aggravates the impacts of a hazard; multivariate, where multiple drivers and/or hazards lead to an impact; temporally compounding, where a succession of hazards leads to an impact; and spatially compounding, where hazards in multiple connected locations cause an aggregated impact. Through structuring compound events and their respective analysis tools, the typology offers an opportunity for deeper insight into their mechanisms and impacts, benefiting the development of effective adaptation strategies. However, the complex nature of compound events results in some cases inevitably fitting into more than one class, necessitating soft boundaries within the typology. Future work must homogenize the available analytical approaches into a robust toolset for compound-event analysis under present and future climate conditions. Research on compound events has increased vastly in the last several years, yet, a typology was absent. This Review proposes a comprehensive classification scheme, incorporating compound events that are preconditioned, multivariate, temporally compounding and spatially compounding events.
455 citations
Authors
Showing all 27203 results
Name | H-index | Papers | Citations |
---|---|---|---|
JoAnn E. Manson | 270 | 1819 | 258509 |
Joseph L. Goldstein | 207 | 556 | 149527 |
Kari Stefansson | 206 | 794 | 174819 |
David Baltimore | 203 | 876 | 162955 |
Mark I. McCarthy | 200 | 1028 | 187898 |
Michael S. Brown | 185 | 422 | 123723 |
Yang Gao | 168 | 2047 | 146301 |
Napoleone Ferrara | 167 | 494 | 140647 |
Marc Weber | 167 | 2716 | 153502 |
Alessandro Melchiorri | 151 | 674 | 116384 |
Andrew D. Hamilton | 151 | 1334 | 105439 |
David P. Strachan | 143 | 472 | 105256 |
Andrew Beretvas | 141 | 1985 | 110059 |
Rainer Wallny | 141 | 1661 | 105387 |
Josh Moss | 139 | 1019 | 89255 |