University of Geneva

About: University of Geneva is a education organization based out in Geneva, Switzerland. It is known for research contribution in the topics: Population & Planet. The organization has 26887 authors who have published 65265 publications receiving 2931373 citations. The organization is also known as: Geneva University & Universite de Geneve.

The Role of Impulsivity in Actual and Problematic Use of the Mobile Phone

Abstract: Several authors have investigated the risks arising from the growth in mobile phone use (e.g. debts incurred by young people). The aims of the present study are (1) to validate a new questionnaire assessing problematic mobile phone use: the Problematic Mobile Phone Use Questionnaire (PMPUQ), and (2) to investigate the relationships between the PMPUQ and the multi-faceted construct of impulsivity. With these aims, 339 subjects were screened using the PMPUQ and the UPPS Impulsive Behaviour Scale (UPPS) which assesses four distinct components associated with impulsive behaviours (urgency, lack of premeditation, lack of perseverance and sensation seeking). The results showed that the PMPUQ has an acceptable fit and assesses four different dimensions of problematic mobile phone use (prohibited use, dangerous use, dependence, financial problems). While each facet of impulsivity played a specific role in mobile phones use, urgency appeared to be the strongest predictor of problematic use. Copyright (C) 2008 John Wiley & Sons, Ltd.

Human colon cancer epithelial cells harbour active HEDGEHOG‐GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion

Abstract: Human colon cancers often start as benign adenomas through loss of APC, leading to enhanced beta CATENIN (beta CAT)/TCF function. These early lesions are efficiently managed but often progress to invasive carcinomas and incurable metastases through additional changes, the nature of which is unclear. We find that epithelial cells of human colon carcinomas (CCs) and their stem cells of all stages harbour an active HH-GLI pathway. Unexpectedly, they acquire a high HEDGEHOG-GLI (HH-GLI) signature coincident with the development of metastases. We show that the growth of CC xenografts, their recurrence and metastases require HH-GLI function, which induces a robust epithelial-to-mesenchymal transition (EMT). Moreover, using a novel tumour cell competition assay we show that the self-renewal of CC stem cells in vivo relies on HH-GLI activity. Our results indicate a key and essential role of the HH-GLI1 pathway in promoting CC growth, stem cell self-renewal and metastatic behavior in advanced cancers. Targeting HH-GLI1, directly or indirectly, is thus predicted to decrease tumour bulk and eradicate CC stem cells and metastases.

Strategic roadmap for an early diagnosis of Alzheimer's disease based on biomarkers

Abstract: The diagnosis of Alzheimer's disease can be improved by the use of biological measures. Biomarkers of functional impairment, neuronal loss, and protein deposition that can be assessed by neuroimaging (ie, MRI and PET) or CSF analysis are increasingly being used to diagnose Alzheimer's disease in research studies and specialist clinical settings. However, the validation of the clinical usefulness of these biomarkers is incomplete, and that is hampering reimbursement for these tests by health insurance providers, their widespread clinical implementation, and improvements in quality of health care. We have developed a strategic five-phase roadmap to foster the clinical validation of biomarkers in Alzheimer's disease, adapted from the approach for cancer biomarkers. Sufficient evidence of analytical validity (phase 1 of a structured framework adapted from oncology) is available for all biomarkers, but their clinical validity (phases 2 and 3) and clinical utility (phases 4 and 5) are incomplete. To complete these phases, research priorities include the standardisation of the readout of these assays and thresholds for normality, the evaluation of their performance in detecting early disease, the development of diagnostic algorithms comprising combinations of biomarkers, and the development of clinical guidelines for the use of biomarkers in qualified memory clinics.

Detection-loophole-free test of quantum nonlocality, and applications.

Abstract: We present a source of entangled photons that violates a Bell inequality free of the ``fair-sampling'' assumption, by over 7 standard deviations. This violation is the first reported experiment with photons to close the detection loophole, and we demonstrate enough ``efficiency'' overhead to eventually perform a fully loophole-free test of local realism. The entanglement quality is verified by maximally violating additional Bell tests, testing the upper limit of quantum correlations. Finally, we use the source to generate ``device-independent'' private quantum random numbers at rates over 4 orders of magnitude beyond previous experiments.