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Institution

University of Geneva

EducationGeneva, Switzerland
About: University of Geneva is a education organization based out in Geneva, Switzerland. It is known for research contribution in the topics: Population & Planet. The organization has 26887 authors who have published 65265 publications receiving 2931373 citations. The organization is also known as: Geneva University & Universite de Geneve.
Topics: Population, Planet, Galaxy, Exoplanet, Stars


Papers
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Journal ArticleDOI
TL;DR: It is reported that both inhibition of respiration and treatment with monensin slow secretion by fibroblasts, and also macrophages and slow intracellular transport (though not discharge per se) by the exocrine pancreatic cells are reported, suggesting a common effect of the cytoplasmic Na/K balance at the Golgi level.
Abstract: The physiology of protein intracellular transport and secretion by cell types thought to be free from short-term control has been compared with that of the pancreatic acinar cell, using pulse-chase protocols to follow biosynthetically-labeled secretory products. Data previously obtained (Tartakoff, A.M., and P. Vassalli. J. Exp. Med. 146:1332-1345) has shown that plasma-cell immunoglobulin (Ig) secretion is inhibited by respiratory inhibitors, by partial Na/K equilibration effected by the carboxylic ionophore monensin, and by calcium withdrawal effected by the carboxylic ionophore A 23187 in the presence of ethylene glycol bis (beta-aminoethylether)-N,N,N',N'-tetraacetic acid (EGTA) and absence of calcium. We report here that both inhibition of respiration and treatment with monensin slow secretion by fibroblasts, and also macrophages and slow intracellular transport (though not discharge per se) by the exocrine pancreatic cells. Attempted calcium withdrawal is inhibitory for fibroblasts but not for macrophages. The elimination of extracellular calcium or addition of 50 mM KCl has no major effect on secretory rate of either fibroblasts or macrophages. Electron microscopic examination of all cell types shows that monensin causes a rapid and impressive dilation of Golgi elements. Combined cell fractionation and autoradiographic studies of the pancreas show that the effect of monensin is exerted at the point of the exit of secretory protein from the Golgi apparatus. Other steps in intracellular transport proceed at normal rates. These observations suggest a common effect of the cytoplasmic Na/K balance at the Golgi level and lead to a model of intracellular transport in which secretory product obligatorily passes through Golgi elements (cisternae?) that are sensitive to monensin. Thus, intracellular transport follows a similar course in both regulated and nonregulated secretory cells up to the level of distal Golgi elements.

434 citations

Journal ArticleDOI
TL;DR: In this article, a method to predict the existence of edge states in graphene ribbons for a large class of boundaries was developed based on the bulk-edge correspondence between the quantized value of the Zak phase, which is a Berry phase across an appropriately chosen one-dimensional Brillouin zone, and the presence of a localized state of momentum at the boundary of the ribbon.
Abstract: We develop a method to predict the existence of edge states in graphene ribbons for a large class of boundaries. This approach is based on the bulk-edge correspondence between the quantized value of the Zak phase $\mathcal{Z}({k}_{\ensuremath{\parallel}})$, which is a Berry phase across an appropriately chosen one-dimensional Brillouin zone, and the existence of a localized state of momentum ${k}_{\ensuremath{\parallel}}$ at the boundary of the ribbon. This bulk-edge correspondence is rigorously demonstrated for a one-dimensional toy model as well as for graphene ribbons with zigzag edges. The range of ${k}_{\ensuremath{\parallel}}$ for which edge states exist in a graphene ribbon is then calculated for arbitrary orientations of the edges. Finally, we show that the introduction of an anisotropy leads to a topological transition in terms of the Zak phase, which modifies the localization properties at the edges. Our approach gives a new geometrical understanding of edge states, and it confirms and generalizes the results of several previous works.

434 citations

Journal ArticleDOI
TL;DR: The study of emotional effects of music is handicapped by a lack of appropriate research paradigms and methods, due to a dearth of conceptual-theoretical analyses of the process underlying emotion production via music as mentioned in this paper.
Abstract: The study of emotional effects of music is handicapped by a lack of appropriate research paradigms and methods, due to a dearth of conceptual-theoretical analyses of the process underlying emotion production via music. It is shown that none of the three major assessment methods for emotion induction – lists of basic emotions, valence-arousal dimensions, and eclectic emotion inventories – is well suited to the task. By focusing on a small number of evolutionarily continuous basic emotions one downplays the more complex forms of emotional processes in humans, especially affective feeling states produced by music which do not serve adaptive behavioral functions. Similarly, a description of emotional effects of music limited to valence and arousal gradations precludes assessment of the kind of qualitative differentiation required by the study of the subtle emotional effects of music. Finally, eclectic lists of emotions generated by researchers to suit the needs of a particular study may lack validity and reli...

434 citations

Journal ArticleDOI
TL;DR: It is discovered that 17β-estradiol (E2), and the two major phytoestrogens, genistein and quercetin, stimulate c-fos expression through ERα as well as through an ER-independent manner via the G protein-coupled receptor homologue GPR30.

434 citations

Journal ArticleDOI
TL;DR: Both strains nodulated a range of mimosoid legumes, especially the Australian species of Acacia, and the tribe Ingeae, and highest compatibilities were found with the papilionoid tribes Phaseoleae and Desmodieae, suggesting that broad host range originated in Southeast Asia and spread outward.
Abstract: Genetically, Rhizobium sp. strain NGR234 and R. fredii USDA257 are closely related. Small differences in their nodulation genes result in NGR234 secreting larger amounts of more diverse lipo-oligosaccharidic Nod factors than USDA257. What effects these differences have on nodulation were analyzed by inoculating 452 species of legumes, representing all three subfamilies of the Leguminosae, as well as the nonlegume Parasponia andersonii, with both strains. The two bacteria nodulated P. andersonii, induced ineffective outgrowths on Delonix regia, and nodulated Chamaecrista fasciculata, a member of the only nodulating genus of the Caesalpinieae tested. Both strains nodulated a range of mimosoid legumes, especially the Australian species of Acacia, and the tribe Ingeae. Highest compatibilities were found with the papilionoid tribes Phaseoleae and Desmodieae. On Vigna spp. (Phaseoleae), both bacteria formed more effective symbioses than rhizobia of the "cowpea" (V. unguiculata) miscellany. USDA257 nodulated an exact subset (79 genera) of the NGR234 hosts (112 genera). If only one of the bacteria formed effective, nitrogen-fixing nodules it was usually NGR234. The only exceptions were with Apios americana, Glycine max, and G. soja. Few correlations can be drawn between Nod-factor substituents and the ability to nodulate specific legumes. Relationships between the ability to nodulate and the origin of the host were not apparent. As both P. andersonii and NGR234 originate from Indonesia/Malaysia/Papua New Guinea, and NGR234's preferred hosts (Desmodiinae/Phaseoleae) are largely Asian, we suggest that broad host range originated in Southeast Asia and spread outward.

434 citations


Authors

Showing all 27203 results

NameH-indexPapersCitations
JoAnn E. Manson2701819258509
Joseph L. Goldstein207556149527
Kari Stefansson206794174819
David Baltimore203876162955
Mark I. McCarthy2001028187898
Michael S. Brown185422123723
Yang Gao1682047146301
Napoleone Ferrara167494140647
Marc Weber1672716153502
Alessandro Melchiorri151674116384
Andrew D. Hamilton1511334105439
David P. Strachan143472105256
Andrew Beretvas1411985110059
Rainer Wallny1411661105387
Josh Moss139101989255
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023171
2022520
20214,280
20204,142
20193,580
20183,395