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Institution

University of Geneva

EducationGeneva, Switzerland
About: University of Geneva is a education organization based out in Geneva, Switzerland. It is known for research contribution in the topics: Population & Planet. The organization has 26887 authors who have published 65265 publications receiving 2931373 citations. The organization is also known as: Geneva University & Universite de Geneve.
Topics: Population, Planet, Galaxy, Exoplanet, Stars


Papers
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Journal ArticleDOI
TL;DR: In this paper, a grid of star models with and without the eects of axial rotation for stars in the mass range between 2 and 60 M for the metallicity Z = 10 5.
Abstract: We calculate a grid of star models with and without the eects of axial rotation for stars in the mass range between 2 and 60 M for the metallicity Z= 10 5 . Star models with initial masses superior or equal to 9 M were computed up to the end of the carbon-burning phase. Star models with masses between 2 and 7 M were evolved beyond the end of the He-burning phase through a few thermal pulses during the AGB phase. Compared to models at Z = 0:02, the low Z models show faster rotating cores and stronger internal-gradients, which favour an important mixing of the chemical elements. The enhancement of N/C at the surface may reach 2 to 3 orders of magnitude for fast rotating stars. Surface enrichments may make the evolved stars less metal poor than they were initially. In very low Z models, primary nitrogen is produced during the He-burning phase by rotational diusion of 12 C into the H-burning shell. A large fraction of the primary 14 N escapes further destruction and enters the envelope of AGB stars, being ejected during the TP-AGB phase and the formation of a planetary nebula. The intermediate mass stars of very lowZ are the main producers of primary 14 N, but massive stars also contribute to this production; no significant primary nitrogen is made in models at metallicity Z= 0:004 or above. We calculate the chemical yields in He, C, N, O and heavy elements and discuss the chemical evolution of the CNO elements at very low Z. Remarkably, the C/ Ov s. O/H diagram is mainly sensitive to the interval of stellar masses, while the N/ Ov s. O/H diagram is mainly sensitive to the average rotation of the stars contributing to the element synthesis. The presently available observations in these diagrams seem to favour contributions either from stars down to about 2 M with normal rotation velocities or from stars above 8 M but with very fast rotation.

420 citations

Journal ArticleDOI
TL;DR: It is reported that the yeast Rag GTPase homolog Gtr1, a component of the vacuolar-membrane-associated EGO complex (EGOC), interacts with and activates TORC1 in an amino-acid-sensitive manner and is regulated by the conserved guanine nucleotide exchange factor (GEF) Vam6.

420 citations

Journal ArticleDOI
TL;DR: In this article, a comprehensive treatment of the derivation of U-Pb isotope ratios and their corresponding uncertainties from isotope dilution thermal ionization mass spectrometric measurements is presented.
Abstract: A comprehensive treatment of the derivation of U-Pb isotope ratios and their corresponding uncertainties from isotope dilution thermal ionization mass spectrometric measurements is presented. Standard parametric statistical methods of error propagation are utilized to convolve uncertainties associated with instrumental mass fractionation, tracer subtraction, blank Pb and U subtraction, and initial common Pb correction. Derivations include errors and error correlations for total sample U/Pb and Pb isotope ratios (including radiogenic and initial common Pb) for two- and three-dimensional isochron calculations, radiogenic U/Pb and Pb isotope ratios for concordia and radiogenic model age calculations, and the propagation of model age errors from radiogenic isotope ratios.

420 citations

Journal ArticleDOI
TL;DR: The results are compatible with the hypothesis that pathogenic B. abortus exploits the autophagic machinery of HeLa cells to establish an intracellular niche favorable for its replication within the ER.
Abstract: Brucella abortus is an intracellular pathogen that replicates within a membrane-bounded compartment. In this study, we have examined the intracellular pathway of the virulent B. abortus strain 2308 (S2308) and the attenuated strain 19 (S19) in HeLa cells. At 10 min after inoculation, both bacterial strains are transiently detected in phagosomes characterized by the presence of early endosomal markers such as the early endosomal antigen 1. At approximately 1 h postinoculation, bacteria are located within a compartment positive for the lysosome-associated membrane proteins (LAMPs) and the endoplasmic reticulum (ER) marker sec61beta but negative for the mannose 6-phosphate receptors and cathepsin D. Interestingly, this compartment is also positive for the autophagosomal marker monodansylcadaverin, suggesting that S2308 and S19 are located in autophagic vacuoles. At 24 h after inoculation, attenuated S19 is degraded in lysosomes, while virulent S2308 multiplies within a LAMP- and cathepsin D-negative but sec61beta- and protein disulfide isomerase-positive compartment. Furthermore, treatment of infected cells with the pore-forming toxin aerolysin from Aeromonas hydrophila causes vacuolation of the bacterial replication compartment. These results are compatible with the hypothesis that pathogenic B. abortus exploits the autophagic machinery of HeLa cells to establish an intracellular niche favorable for its replication within the ER.

419 citations

Journal ArticleDOI
TL;DR: The Stueckelberg mechanism was introduced in this paper to reveal a symmetry of a gauge-fixed theory, which led to applications in many areas not anticipated by the author, such as strings.
Abstract: In 1938, Stueckelberg introduced a scalar field which makes an Abelian gauge theory massive but preserves gauge invariance. The Stueckelberg mechanism is the introduction of new fields to reveal a symmetry of a gauge--fixed theory. We first review the Stueckelberg mechanism in the massive Abelian gauge theory. We then extend this idea to the standard model, stueckelberging the hypercharge U(1) and thus giving a mass to the physical photon. This introduces an infrared regulator for the photon in the standard electroweak theory, along with a modification of the weak mixing angle accompanied by a plethora of new effects. Notably, neutrinos couple to the photon and charged leptons have also a pseudo-vector coupling. Finally, we review the historical influence of Stueckelberg's 1938 idea, which led to applications in many areas not anticipated by the author, such as strings. We describe the numerous proposals to generalize the Stueckelberg trick to the non-Abelian case with the aim to find alternatives to the standard model. Nevertheless, the Higgs mechanism in spontaneous symmetry breaking remains the only presently known way to give masses to non-Abelian vector fields in a renormalizable and unitary theory.

419 citations


Authors

Showing all 27203 results

NameH-indexPapersCitations
JoAnn E. Manson2701819258509
Joseph L. Goldstein207556149527
Kari Stefansson206794174819
David Baltimore203876162955
Mark I. McCarthy2001028187898
Michael S. Brown185422123723
Yang Gao1682047146301
Napoleone Ferrara167494140647
Marc Weber1672716153502
Alessandro Melchiorri151674116384
Andrew D. Hamilton1511334105439
David P. Strachan143472105256
Andrew Beretvas1411985110059
Rainer Wallny1411661105387
Josh Moss139101989255
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023171
2022520
20214,280
20204,142
20193,580
20183,395