Institution
University of Geneva
Education•Geneva, Switzerland•
About: University of Geneva is a education organization based out in Geneva, Switzerland. It is known for research contribution in the topics: Population & Planet. The organization has 26887 authors who have published 65265 publications receiving 2931373 citations. The organization is also known as: Geneva University & Universite de Geneve.
Topics: Population, Planet, Galaxy, Exoplanet, Stars
Papers published on a yearly basis
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TL;DR: It is shown that the non-local correlations of entangled quantum particles can be used to certify the presence of genuine randomness, and it is thereby possible to design a cryptographically secure random number generator that does not require any assumption about the internal working of the device.
Abstract: True randomness does not exist in classical physics, where randomness is necessarily a result of forces that may be unknown but exist. The quantum world, however, is intrinsically truly random. This is difficult to prove, as it is not readily distinguishable from noise and other uncontrollable factors. Now Pironio et al. present proof of a quantitative relationship between two fundamental concepts of quantum mechanics — randomness and the non-locality of entangled particles. They first show theoretically that the violation of a Bell inequality certifies the generation of new randomness, independently of any implementation details. To illustrate the approach, they then perform an experiment in which — as confirmed using the theoretical tools that they developed — 42 new random bits have been generated. As well as having conceptual implications, this work has practical implications for cryptography and for numerical simulation of physical and biological systems. Here it is shown, both theoretically and experimentally, that non-local correlations between entangled quantum particles can be used for a new cryptographic application — the generation of certified private random numbers — that is impossible to achieve classically. The results have implications for future device-independent quantum information experiments and for addressing fundamental issues regarding the randomness of quantum theory. Randomness is a fundamental feature of nature and a valuable resource for applications ranging from cryptography and gambling to numerical simulation of physical and biological systems. Random numbers, however, are difficult to characterize mathematically1, and their generation must rely on an unpredictable physical process2,3,4,5,6. Inaccuracies in the theoretical modelling of such processes or failures of the devices, possibly due to adversarial attacks, limit the reliability of random number generators in ways that are difficult to control and detect. Here, inspired by earlier work on non-locality-based7,8,9 and device-independent10,11,12,13,14 quantum information processing, we show that the non-local correlations of entangled quantum particles can be used to certify the presence of genuine randomness. It is thereby possible to design a cryptographically secure random number generator that does not require any assumption about the internal working of the device. Such a strong form of randomness generation is impossible classically and possible in quantum systems only if certified by a Bell inequality violation15. We carry out a proof-of-concept demonstration of this proposal in a system of two entangled atoms separated by approximately one metre. The observed Bell inequality violation, featuring near perfect detection efficiency, guarantees that 42 new random numbers are generated with 99 per cent confidence. Our results lay the groundwork for future device-independent quantum information experiments and for addressing fundamental issues raised by the intrinsic randomness of quantum theory.
1,337 citations
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National Institutes of Health1, University of Geneva2, Johns Hopkins University3, University of Washington4, Erasmus University Rotterdam5, University of Texas Health Science Center at Houston6, University of Iceland7, Boston University8, Cedars-Sinai Medical Center9, Harvard University10, Group Health Cooperative11
TL;DR: A genome-wide association study of systolic (SBP) and diastolic (DBP) blood pressure and hypertension in the CHARGE Consortium identifies 13 SNPs for SBP, 20 for DBP and 10 for hypertension at P < 4 × 10−7.
Abstract: Blood pressure is a major cardiovascular disease risk factor. To date, few variants associated with interindividual blood pressure variation have been identified and replicated. Here we report results of a genome-wide association study of systolic (SBP) and diastolic (DBP) blood pressure and hypertension in the CHARGE Consortium (n = 29,136), identifying 13 SNPs for SBP, 20 for DBP and 10 for hypertension at P < 4 × 10(-7). The top ten loci for SBP and DBP were incorporated into a risk score; mean BP and prevalence of hypertension increased in relation to the number of risk alleles carried. When ten CHARGE SNPs for each trait were included in a joint meta-analysis with the Global BPgen Consortium (n = 34,433), four CHARGE loci attained genome-wide significance (P < 5 × 10(-8)) for SBP (ATP2B1, CYP17A1, PLEKHA7, SH2B3), six for DBP (ATP2B1, CACNB2, CSK-ULK3, SH2B3, TBX3-TBX5, ULK4) and one for hypertension (ATP2B1). Identifying genes associated with blood pressure advances our understanding of blood pressure regulation and highlights potential drug targets for the prevention or treatment of hypertension.
1,333 citations
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TL;DR: In this article, a variety of diagnostic methods are used to determine how heat waves, heavy precipitation, drought, wind storms, and storm surges change between present (1961-90) and future (2071-2100) climate on the basis of regional climate model simulations produced by the PRUDENCE project.
Abstract: This paper presents an overview of changes in the extreme events that are most likely to affect Europe in forthcoming decades. A variety of diagnostic methods are used to determine how heat waves, heavy precipitation, drought, wind storms, and storm surges change between present (1961–90) and future (2071–2100) climate on the basis of regional climate model simulations produced by the PRUDENCE project. A summary of the main results follows. Heat waves – Regional surface warming causes the frequency, intensity and duration of heat waves to increase over Europe. By the end of the twenty first century, countries in central Europe will experience the same number of hot days as are currently experienced in southern Europe. The intensity of extreme temperatures increases more rapidly than the intensity of more moderate temperatures over the continental interior due to increases in temperature variability. Precipitation – Heavy winter precipitation increases in central and northern Europe and decreases in the south; heavy summer precipitation increases in north-eastern Europe and decreases in the south. Mediterranean droughts start earlier in the year and last longer. Winter storms – Extreme wind speeds increase between 45°N and 55°N, except over and south of the Alps, and become more north-westerly than cuurently. These changes are associated with reductions in mean sea-level pressure, leading to more North Sea storms and a corresponding increase in storm surges along coastal regions of Holland, Germany and Denmark, in particular. These results are found to depend to different degrees on model formulation. While the responses of heat waves are robust to model formulation, the magnitudes of changes in precipitation and wind speed are sensitive to the choice of regional model, and the detailed patterns of these changes are sensitive to the choice of the driving global model. In the case of precipitation, variation between models can exceed both internal variability and variability between different emissions scenarios.
1,317 citations
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Columbia University1, Complutense University of Madrid2, Ege University3, University of Birmingham4, Rutgers University5, University of Hong Kong6, Boston University7, University of Michigan8, University of Pisa9, University of Louisville10, University of Bonn11, University of Pennsylvania12, University at Buffalo13, University of Greifswald14, Ohio State University15, VU University Amsterdam16, Technion – Israel Institute of Technology17, Peking University18, University of Geneva19, University College London20, University of North Carolina at Chapel Hill21, University of Queensland22
TL;DR: A new periodontitis classification scheme has been adopted, in which forms of the disease previously recognized as "chronic" or "aggressive" are now grouped under a single category ("periodontitis") and are further characterized based on a multi-dimensional staging and grading system as mentioned in this paper.
Abstract: A new periodontitis classification scheme has been adopted, in which forms of the disease previously recognized as "chronic" or "aggressive" are now grouped under a single category ("periodontitis") and are further characterized based on a multi-dimensional staging and grading system. Staging is largely dependent upon the severity of disease at presentation as well as on the complexity of disease management, while grading provides supplemental information about biological features of the disease including a history-based analysis of the rate of periodontitis progression; assessment of the risk for further progression; analysis of possible poor outcomes of treatment; and assessment of the risk that the disease or its treatment may negatively affect the general health of the patient. Necrotizing periodontal diseases, whose characteristic clinical phenotype includes typical features (papilla necrosis, bleeding, and pain) and are associated with host immune response impairments, remain a distinct periodontitis category. Endodontic-periodontal lesions, defined by a pathological communication between the pulpal and periodontal tissues at a given tooth, occur in either an acute or a chronic form, and are classified according to signs and symptoms that have direct impact on their prognosis and treatment. Periodontal abscesses are defined as acute lesions characterized by localized accumulation of pus within the gingival wall of the periodontal pocket/sulcus, rapid tissue destruction and are associated with risk for systemic dissemination.
1,301 citations
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TL;DR: In this article, the authors consider the Lagrangian of gravity covariantly amended by the mass and polynomial interaction terms with arbitrary coefficients and investigate the consistency of such a theory in the decoupling limit, up to the fifth order in the nonlinearities.
Abstract: We consider the Lagrangian of gravity covariantly amended by the mass and polynomial interaction terms with arbitrary coefficients and reinvestigate the consistency of such a theory in the decoupling limit, up to the fifth order in the nonlinearities. We calculate explicitly the self-interactions of the helicity-0 mode, as well as the nonlinear mixing between the helicity-0 and -2 modes. We show that ghostlike pathologies in these interactions disappear for special choices of the polynomial interactions and argue that this result remains true to all orders in the decoupling limit. Moreover, we show that the linear and some of the nonlinear mixing terms between the helicity-0 and -2 modes can be absorbed by a local change of variables, which then naturally generates the cubic, quartic, and quintic Galileon interactions, introduced in a different context. We also point out that the mixing between the helicity-0 and -2 modes can be at most quartic in the decoupling limit. Finally, we discuss the implications of our findings for the consistency of the effective field theory away from the decoupling limit, and for the Boulware-Deser problem.
1,300 citations
Authors
Showing all 27203 results
Name | H-index | Papers | Citations |
---|---|---|---|
JoAnn E. Manson | 270 | 1819 | 258509 |
Joseph L. Goldstein | 207 | 556 | 149527 |
Kari Stefansson | 206 | 794 | 174819 |
David Baltimore | 203 | 876 | 162955 |
Mark I. McCarthy | 200 | 1028 | 187898 |
Michael S. Brown | 185 | 422 | 123723 |
Yang Gao | 168 | 2047 | 146301 |
Napoleone Ferrara | 167 | 494 | 140647 |
Marc Weber | 167 | 2716 | 153502 |
Alessandro Melchiorri | 151 | 674 | 116384 |
Andrew D. Hamilton | 151 | 1334 | 105439 |
David P. Strachan | 143 | 472 | 105256 |
Andrew Beretvas | 141 | 1985 | 110059 |
Rainer Wallny | 141 | 1661 | 105387 |
Josh Moss | 139 | 1019 | 89255 |