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Institution

University of Georgia

EducationAthens, Georgia, United States
About: University of Georgia is a education organization based out in Athens, Georgia, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 41934 authors who have published 93622 publications receiving 3713212 citations. The organization is also known as: UGA & Franklin College.
Topics: Population, Poison control, Gene, Genome, Virus


Papers
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Journal ArticleDOI
TL;DR: The results suggest that IRX9 is required for normal GX elongation and indicate roles for IRX8 and FRA8 in the synthesis of the glycosyl sequence at the GX reducing end.
Abstract: Mutations of Arabidopsis thaliana IRREGULAR XYLEM8 ( IRX8 ) and IRX9 were previously shown to cause a collapsed xylem phenotype and decreases in xylose and cellulose in cell walls. In this study, we characterized IRX8 and IRX9 and performed chemical and structural analyses of glucuronoxylan (GX) from irx8 and irx9 plants. IRX8 and IRX9 are expressed specifically in cells undergoing secondary wall thickening, and their encoded proteins are targeted to the Golgi, where GX is synthesized. 1 H-NMR spectroscopy showed that the reducing end of Arabidopsis GX contains the glycosyl sequence 4-β-d-Xyl p -(1→4)-β-d-Xyl p -(1→3)-α-l-Rha p -(1→2)-α-d-Gal p A-(1→4)-d-Xyl p , which was previously identified in birch ( Betula verrucosa ) and spruce ( Picea abies ) GX. This indicates that the reducing end structure of GXs is evolutionarily conserved in woody and herbaceous plants. This sequence is more abundant in irx9 GX than in the wild type, whereas irx8 and fragile fiber8 ( fra8 ) plants are nearly devoid of it. The number of GX chains increased and the GX chain length decreased in irx9 plants. Conversely, the number of GX chains decreased and the chain length heterodispersity increased in irx8 and fra8 plants. Our results suggest that IRX9 is required for normal GX elongation and indicate roles for IRX8 and FRA8 in the synthesis of the glycosyl sequence at the GX reducing end.

408 citations

Journal ArticleDOI
TL;DR: In this paper, a complete and optimized scheme of lettered marine isotope substages spanning the last 1.0 million years is proposed, based on the LR04 stack of marine benthic oxygen isotope records, and thus it is grounded in a continuous record responsive largely to changes in ice volume that are inherently global.

408 citations

Journal ArticleDOI
09 Sep 2010-Nature
TL;DR: It is shown that MEC-17, a protein related to the Gcn5 histone acetyltransferases and required for the function of touch receptor neurons in Caenorhabditis elegans, acts as a K40-specific acetyl transferase for α-tubulin.
Abstract: In most eukaryotic cells, subsets of microtubules are adapted for specific functions by post-translational modifications (PTMs) of tubulin subunits. Acetylation of the epsilon-amino group of K40 on alpha-tubulin is a conserved PTM on the luminal side of microtubules that was discovered in the flagella of Chlamydomonas reinhardtii. Studies on the significance of microtubule acetylation have been limited by the undefined status of the alpha-tubulin acetyltransferase. Here we show that MEC-17, a protein related to the Gcn5 histone acetyltransferases and required for the function of touch receptor neurons in Caenorhabditis elegans, acts as a K40-specific acetyltransferase for alpha-tubulin. In vitro, MEC-17 exclusively acetylates K40 of alpha-tubulin. Disruption of the Tetrahymena MEC-17 gene phenocopies the K40R alpha-tubulin mutation and makes microtubules more labile. Depletion of MEC-17 in zebrafish produces phenotypes consistent with neuromuscular defects. In C. elegans, MEC-17 and its paralogue W06B11.1 are redundantly required for acetylation of MEC-12 alpha-tubulin, and contribute to the function of touch receptor neurons partly via MEC-12 acetylation and partly via another function, possibly by acetylating another protein. In summary, we identify MEC-17 as an enzyme that acetylates the K40 residue of alpha-tubulin, the only PTM known to occur on the luminal surface of microtubules.

408 citations

Journal ArticleDOI
TL;DR: This article found that organizational climate made a significant contribution to safety climate, even after controlling for the other more safety-relevant variables, such as environmental conditions, safety-related policies and programs, and general organizational climate, accounted for 55% of the variance in perceived safety.

407 citations

Journal ArticleDOI
TL;DR: In this paper, the authors distinguish novelty from newness and argue that the tasks of new venture top management teams vary with new venture novelty, and that as novelty increases, the information processing requirements on the TMT change as well.

407 citations


Authors

Showing all 42268 results

NameH-indexPapersCitations
Rob Knight2011061253207
Feng Zhang1721278181865
Zhenan Bao169865106571
Carl W. Cotman165809105323
Yoshio Bando147123480883
Mark Raymond Adams1471187135038
Han Zhang13097058863
Dmitri Golberg129102461788
Godfrey D. Pearlson12874058845
Douglas E. Soltis12761267161
Richard A. Dixon12660371424
Ajit Varki12454258772
Keith A. Johnson12079851034
Gustavo E. Scuseria12065895195
Julian I. Schroeder12031550323
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023125
2022542
20214,670
20204,504
20194,098
20183,994