University of Georgia

About: University of Georgia is a education organization based out in Athens, Georgia, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 41934 authors who have published 93622 publications receiving 3713212 citations. The organization is also known as: UGA & Franklin College.

Information systems and environmentally sustainable development: energy informatics and new directions for the is community

Abstract: While many corporations and Information Systems units recognize that environmental sustainability is an urgent problem to address, the IS academic community has been slow to acknowledge the problem and take action We propose ways for the IS community to engage in the development of environmentally sustainable business practices Specifically, as IS researchers, educators, journal editors, and association leaders, we need to demonstrate how the transformative power of IS can be leveraged to create an ecologically sustainable society In this Issues and Opinions piece, we advocate a research agenda to establish a new subfield of energy informatics, which applies information systems thinking and skills to increase energy efficiency We also articulate how IS scholars can incorporate environmental sustainability as an underlying foundation in their teaching, and how IS leaders can embrace environmental sustainability in their core principles and foster changes that reduce the environmental impact of our community

A reference genome for common bean and genome-wide analysis of dual domestications

Abstract: Common bean (Phaseolus vulgaris L.) is the most important grain legume for human consumption and has a role in sustainable agriculture owing to its ability to fix atmospheric nitrogen. We assembled 473 Mb of the 587-Mb genome and genetically anchored 98% of this sequence in 11 chromosome-scale pseudomolecules. We compared the genome for the common bean against the soybean genome to find changes in soybean resulting from polyploidy. Using resequencing of 60 wild individuals and 100 landraces from the genetically differentiated Mesoamerican and Andean gene pools, we confirmed 2 independent domestications from genetic pools that diverged before human colonization. Less than 10% of the 74 Mb of sequence putatively involved in domestication was shared by the two domestication events. We identified a set of genes linked with increased leaf and seed size and combined these results with quantitative trait locus data from Mesoamerican cultivars. Genes affected by domestication may be useful for genomics-enabled crop improvement.

The role of espoused national cultural values in technology acceptance

Abstract: Prior research has examined age, gender, experience, and voluntariness as the main moderators of beliefs on technology acceptance. This paper extends this line of research beyond these demographic and situational variables. Motivated by research that suggests that behavioral models do not universally hold across cultures, the paper identifies espoused national cultural values as an important set of individual difference moderators in technology acceptance. Building on research in psychological anthropology and cultural psychology that assesses cultural traits by personality tests at the individual level of analysis, we argue that individuals espouse national cultural values to differing degrees. These espoused national cultural values of masculinity/femininity, individualism/collectivism, power distance, and uncertainty avoidance are incorporated into an extended model of technology acceptance as moderators. We conducted two studies to test our model. Results indicated that, as hypothesized, social norms are stronger determinants of intended behavior for individuals who espouse feminine and high uncertainty avoidance cultural values. Contrary to expectations, espoused masculinity/femininity values did not moderate the relationship between perceived usefulness and behavioral intention but, as expected, did moderate the relationship between perceived ease of use and behavioral intention.

The Cholinergic Hypothesis of Age and Alzheimer's Disease-Related Cognitive Deficits: Recent Challenges and Their Implications for Novel Drug Development

Abstract: The cholinergic hypothesis was initially presented over 20 years ago and suggests that a dysfunction of acetylcholine containing neurons in the brain contributes substantially to the cognitive decline observed in those with advanced age and Alzheimer's disease (AD). This premise has since served as the basis for the majority of treatment strategies and drug development approaches for AD to date. Recent studies of the brains of patients who had mild cognitive impairment or early stage AD in which choline acetyltransferase and/or acetylcholinesterase activity was unaffected (or even up-regulated) have, however, led some to challenge the validity of the hypothesis as well as the rationale for using cholinomimetics to treat the disorder, particularly in the earlier stages. These challenges, primarily based on assays of post mortem enzyme activity, should be taken in perspective and evaluated within the wide range of cholinergic abnormalities known to exist in both aging and AD. The results of both post mortem and antemortem studies in aged humans and AD patients, as well as animal experiments suggest that a host of cholinergic abnormalities including alterations in choline transport, acetylcholine release, nicotinic and muscarinic receptor expression, neurotrophin support, and perhaps axonal transport may all contribute to cognitive abnormalities in aging and AD. Cholinergic abnormalities may also contribute to noncognitive behavioral abnormalities as well as the deposition of toxic neuritic plaques in AD. Therefore, cholinergic-based strategies will likely remain valid as one approach to rational drug development for the treatment of AD other forms of dementia.