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Institution

University of Gothenburg

EducationGothenburg, Sweden
About: University of Gothenburg is a education organization based out in Gothenburg, Sweden. It is known for research contribution in the topics: Population & Poison control. The organization has 23855 authors who have published 65241 publications receiving 2606327 citations. The organization is also known as: Göteborg University & Gothenburg University.


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Journal ArticleDOI
TL;DR: An analysis of the extent to which autism and Asperger syndrome coexist with other disorders is provided to provide a clinically useful analysis.
Abstract: Objective: To provide a clinically useful analysis of the extent to which autism and Asperger syndrome coexist with other disorders. Method: Selective review of the literature detailing data pertaining to symptoms and disorders sometimes encountered in connection with autism or Asperger syndrome. Results: A large number of medical conditions, psychiatric disorders and behavioural and motor dyscontrol symptoms are associated with autism and Asperger syndrome. Conclusion: Comorbidity is to be expected in autism spectrum disorders — directly or indirectly. Comorbid conditions may be markers for underlying pathophysiology and suggest a more varied treatment approach. There is a great need for in-depth research into this area, meaning that the exclusion criteria of current diagnostic manuals, i.e. those that rule out a diagnosis of autism in some disorders, and a diagnosis of certain other disorders in autism may have to be revised.

535 citations

Journal ArticleDOI
Emmanouela Repapi1, Ian Sayers2, Louise V. Wain1, Paul Burton1, Toby Johnson3, Ma'en Obeidat2, Jing Hua Zhao4, Adaikalavan Ramasamy5, Guangju Zhai6, Veronique Vitart7, Jennifer E. Huffman7, Wilmar Igl8, E Albrecht, Panagiotis Deloukas9, John Henderson10, Raquel Granell10, Wendy L. McArdle10, Alicja R. Rudnicka11, Inês Barroso9, Loos Rjf.4, Nicholas J. Wareham4, Linda Mustelin12, Taina Rantanen13, Ida Surakka12, Ida Surakka14, Medea Imboden15, H E Wichmann16, Ivica Grković16, Stipan Janković16, Lina Zgaga17, Hartikainen A-L.14, Hartikainen A-L.12, Hartikainen A-L.9, Leena Peltonen12, Leena Peltonen9, Leena Peltonen14, Ulf Gyllensten8, Åsa Johansson8, Ghazal Zaboli8, Harry Campbell18, Sarah H. Wild18, James F. Wilson18, Sven Gläser19, Georg Homuth19, Henry Völzke19, Massimo Mangino6, Nicole Soranzo6, Nicole Soranzo9, Tim D. Spector6, Ozren Polasek17, Igor Rudan18, Igor Rudan16, Alan F. Wright7, Markku Heliövaara14, Samuli Ripatti14, Samuli Ripatti12, Anneli Pouta14, Åsa Torinsson Naluai20, Olin A-C.20, Kjell Torén20, Mark E. Cooper21, Alan James22, Lyle J. Palmer21, Lyle J. Palmer22, Aroon D. Hingorani23, S.G. Wannamethee11, Peter H. Whincup11, George Davey Smith10, Shah Ebrahim24, Tricia M. McKeever2, Ian D. Pavord25, Andrew K. MacLeod7, Andrew D. Morris26, David J. Porteous7, Cyrus Cooper27, Cyrus Cooper28, Elaine M. Dennison27, Seif O. Shaheen14, Stefan Karrasch, E Schnabel, Holger Schulz, H Grallert, Nabila Bouatia-Naji29, Jérôme Delplanque29, Philippe Froguel5, Philippe Froguel29, John D Blakey2, John Britton2, Richard W Morris23, John W. Holloway27, Debbie A Lawlor10, Jennie Hui22, Jennie Hui30, Fredrik Nyberg20, Fredrik Nyberg31, Jarvelin M-R.32, Catherine Jackson33, Mika Kähönen32, Jaakko Kaprio12, Jaakko Kaprio14, Nicole Probst-Hensch30, Nicole Probst-Hensch15, Beate Koch19, Caroline Hayward7, David M. Evans10, Paul Elliott5, Paul Elliott34, David P. Strachan11, Ian P. Hall2, Martin D. Tobin1 
TL;DR: Genome-wide association with forced expiratory volume in 1 s (FEV1) and the ratio of FEV1 to forced vital capacity (FVC) in the SpiroMeta consortium offers mechanistic insight into pulmonary function regulation and indicate potential targets for interventions to alleviate respiratory disease.
Abstract: Pulmonary function measures are heritable traits that predict morbidity and mortality and define chronic obstructive pulmonary disease (COPD). We tested genome-wide association with forced expiratory volume in 1 s (FEV(1)) and the ratio of FEV(1) to forced vital capacity (FVC) in the SpiroMeta consortium (n = 20,288 individuals of European ancestry). We conducted a meta-analysis of top signals with data from direct genotyping (n < or = 32,184 additional individuals) and in silico summary association data from the CHARGE Consortium (n = 21,209) and the Health 2000 survey (n < or = 883). We confirmed the reported locus at 4q31 and identified associations with FEV(1) or FEV(1)/FVC and common variants at five additional loci: 2q35 in TNS1 (P = 1.11 x 10(-12)), 4q24 in GSTCD (2.18 x 10(-23)), 5q33 in HTR4 (P = 4.29 x 10(-9)), 6p21 in AGER (P = 3.07 x 10(-15)) and 15q23 in THSD4 (P = 7.24 x 10(-15)). mRNA analyses showed expression of TNS1, GSTCD, AGER, HTR4 and THSD4 in human lung tissue. These associations offer mechanistic insight into pulmonary function regulation and indicate potential targets for interventions to alleviate respiratory disease.

535 citations

Journal ArticleDOI
TL;DR: According to these provisional classification criteria, patients ≥50 years old presenting with bilateral shoulder pain, not better explained by an alternative pathology, can be classified as having PMR in the presence of morning stiffness>45 minutes, elevated CRP and/or ESR and new hip pain.
Abstract: The objective of this study was to develop EULAR/ACR classification criteria for polymyalgia rheumatica (PMR). Candidate criteria were evaluated in a 6-month prospective cohort study of 125 patients with new onset PMR and 169 non-PMR comparison subjects with conditions mimicking PMR. A scoring algorithm was developed based on morning stiffness >45 minutes (2 points), hip pain/limited range of motion (1 point), absence of RF and/or ACPA (2 points), and absence of peripheral joint pain (1 point). A score ≥4 had 68% sensitivity and 78% specificity for discriminating all comparison subjects from PMR. The specificity was higher (88%) for discriminating shoulder conditions from PMR and lower (65%) for discriminating RA from PMR. Adding ultrasound, a score ≥5 had increased sensitivity to 66% and specificity to 81%. According to these provisional classification criteria, patients ≥50 years old presenting with bilateral shoulder pain, not better explained by an alternative pathology, can be classified as having PMR in the presence of morning stiffness>45 minutes, elevated CRP and/or ESR and new hip pain. These criteria are not meant for diagnostic purposes.

535 citations

Journal ArticleDOI
TL;DR: A computerized analysing system is described for the measurement of wall thickness and plaque area on the carotid and femoral arteries and it is suggested that if measurements on the near wall are performed, measurements from the far wall should be presented separately, and if lumen diameter is measured, that this measurement is carried out according to the leading edge principle.
Abstract: SUMMARY A B-mode [two-dimensional (2D)] image from the carotid artery may be described as containing seven echo zones. The aim of the present work is to discuss how lumen diameter and wall thickness can be measured from these zones, and to review some of the basic principles of ultrasound physics and imaging. Simple experiments were performed to identify the echoes defining intima-lumen interfaces. The results showed that: 1 The intima-media thickness of the near wall cannot be measured in a valid way. 2 The lumen diameter of a blood vessel is defined by the distance from the leading edge of the intima-lumen interface of the near wall (echo zone 3) to the leading edge of the lumen-intima interface of the fall wall (echo zone 5). 3 Previously published studies have validated the intima-media complex of the far wall as the distance from the leading edge of the lumen-intima interface of the far wall to the leading edge of the media-adventitia interface of the far wall (echo zone 7). We suggest that if measurements on the near wall are performed, measurements from the far wall should also be presented separately, and if lumen diameter is measured, that this measurement is carried out according to the leading edge principle. We describe a computerized analysing system for the measurement of wall thickness and plaque area on the carotid and femoral arteries. The system is based on a low-cost PC and a frame grabber board and calculates minimum, maximum and mean values of lumen diameter and wall thickness from a section of the artery.

535 citations

Journal ArticleDOI
TL;DR: Functional and anatomical evidence for abnormal neuroimmune interactions has been found in patients with IBS and the link between immune alterations and severity of gastrointestinal symptoms and the positive effect of anti-inflammatory treatments in IBS further highlight the relevance of neuro immune interactions in this condition.
Abstract: IBS is one of the most common functional gastrointestinal disorders worldwide and is thought to be the result of disturbed neural function along the brain-gut axis. The mechanisms behind this disturbance are not clear, but important roles for low-grade inflammation and immunological alterations in the development of symptoms compatible with IBS have become evident. The development of long-standing gastrointestinal symptoms after infectious gastroenteritis and patients with IBD in remission frequently having functional gastrointestinal symptoms support this hypothesis. An increased innate immune activity in the intestinal mucosa and in blood is found in subpopulations of patients with IBS. Mast cells and monocytes seem to be particularly important. In addition, studies have demonstrated that IBS may be associated with an activated adaptive immune response. Increased epithelial barrier permeability and an abnormal gut flora might lead to increased activation of the intestinal immune system. Functional and anatomical evidence for abnormal neuroimmune interactions has been found in patients with IBS. The link between immune alterations and severity of gastrointestinal symptoms and the positive effect of anti-inflammatory treatments in IBS further highlight the relevance of neuroimmune interactions in this condition.

534 citations


Authors

Showing all 24120 results

NameH-indexPapersCitations
Peter J. Barnes1941530166618
Luigi Ferrucci1931601181199
Richard H. Friend1691182140032
Napoleone Ferrara167494140647
Timothy A. Springer167669122421
Anders Björklund16576984268
Hua Zhang1631503116769
Kaj Blennow1601845116237
Leif Groop158919136056
Tomas Hökfelt158103395979
Johan G. Eriksson1561257123325
Naveed Sattar1551326116368
Paul Elliott153773103839
Claude Bouchard1531076115307
Hakon Hakonarson152968101604
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023145
2022539
20215,065
20204,657
20194,254
20183,850