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University of Gothenburg
Education•Gothenburg, Sweden•
About: University of Gothenburg is a education organization based out in Gothenburg, Sweden. It is known for research contribution in the topics: Population & Health care. The organization has 23855 authors who have published 65241 publications receiving 2606327 citations. The organization is also known as: Göteborg University & Gothenburg University.
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University of Edinburgh1, Aarhus University2, University of Colorado Boulder3, Institute of Arctic and Alpine Research4, National Ecological Observatory Network5, Smithsonian Institution6, Lund University7, VU University Amsterdam8, University of Lapland9, Northern Arizona University10, Bigelow Laboratory For Ocean Sciences11, University of British Columbia12, University of Washington13, Grand Valley State University14, Swiss Federal Institute for Forest, Snow and Landscape Research15, Max Planck Society16, University of Zurich17, Université de Sherbrooke18, University of Greifswald19, University of Parma20, Memorial University of Newfoundland21, Université du Québec à Trois-Rivières22, University of Gothenburg23, Leiden University24, University of California, Riverside25, Qatar University26, Mississippi State University27, University of Barcelona28, Utrecht University29, Umeå University30, Adam Mickiewicz University in Poznań31, University of Alaska Anchorage32, Wageningen University and Research Centre33, Alaska Department of Fish and Game34, University of Tromsø35, University of Vienna36, University of Copenhagen37, University of Oulu38, Helmholtz Centre for Environmental Research - UFZ39, Spanish National Research Council40, Queen's University41, Saint Mary's University42, Oak Ridge National Laboratory43, University of Aberdeen44, University of Saskatchewan45, Vrije Universiteit Brussel46, University of Victoria47, Swiss Federal Institute of Aquatic Science and Technology48, Norwegian University of Science and Technology49, Research Institute for Nature and Forest50, Florida International University51, Moscow State University52, University of Alaska Fairbanks53, University of Waterloo54, Laval University55, Deakin University56, University of Bonn57, United States Forest Service58, Simon Fraser University59, University Centre in Svalbard60, University of Iceland61, United States Fish and Wildlife Service62, Colorado State University63, University of Texas at El Paso64, University of Stirling65, University of Innsbruck66, University of Oxford67, Rocky Mountain Biological Laboratory68, Pacific Northwest National Laboratory69, University of Camerino70, University of Insubria71, University of New South Wales72, University of Manchester73, National University of Cordoba74, Santa Fe Institute75, University of Arizona76, Harvard University77, King Juan Carlos University78, Estonian University of Life Sciences79, Kyoto University80, World Agroforestry Centre81, Radboud University Nijmegen82, Forschungszentrum Jülich83, Macquarie University84, University of Regensburg85, University of Sydney86, University of Minnesota87, Santa Clara University88, Algoma University89, Komarov Botanical Institute90, University of Wisconsin–Eau Claire91
TL;DR: Biome-wide relationships between temperature, moisture and seven key plant functional traits across the tundra and over time show that community height increased with warming across all sites, whereas other traits lagged behind predicted rates of change.
Abstract: The tundra is warming more rapidly than any other biome on Earth, and the potential ramifications are far-reaching because of global feedback effects between vegetation and climate. A better understanding of how environmental factors shape plant structure and function is crucial for predicting the consequences of environmental change for ecosystem functioning. Here we explore the biome-wide relationships between temperature, moisture and seven key plant functional traits both across space and over three decades of warming at 117 tundra locations. Spatial temperature-trait relationships were generally strong but soil moisture had a marked influence on the strength and direction of these relationships, highlighting the potentially important influence of changes in water availability on future trait shifts in tundra plant communities. Community height increased with warming across all sites over the past three decades, but other traits lagged far behind predicted rates of change. Our findings highlight the challenge of using space-for-time substitution to predict the functional consequences of future warming and suggest that functions that are tied closely to plant height will experience the most rapid change. They also reveal the strength with which environmental factors shape biotic communities at the coldest extremes of the planet and will help to improve projections of functional changes in tundra ecosystems with climate warming.
425 citations
TL;DR: Plasma pTau181 concentrations are elevated specifically in patients diagnosed with Alzheimer’s disease compared to those diagnosed with frontotemporal lobar degeneration or elderly controls, supporting its further development as a blood-based biomarker for AD.
Abstract: With the potential development of new disease-modifying Alzheimer's disease (AD) therapies, simple, widely available screening tests are needed to identify which individuals, who are experiencing symptoms of cognitive or behavioral decline, should be further evaluated for initiation of treatment. A blood-based test for AD would be a less invasive and less expensive screening tool than the currently approved cerebrospinal fluid or amyloid β positron emission tomography (PET) diagnostic tests. We examined whether plasma tau phosphorylated at residue 181 (pTau181) could differentiate between clinically diagnosed or autopsy-confirmed AD and frontotemporal lobar degeneration. Plasma pTau181 concentrations were increased by 3.5-fold in AD compared to controls and differentiated AD from both clinically diagnosed (receiver operating characteristic area under the curve of 0.894) and autopsy-confirmed frontotemporal lobar degeneration (area under the curve of 0.878). Plasma pTau181 identified individuals who were amyloid β-PET-positive regardless of clinical diagnosis and correlated with cortical tau protein deposition measured by 18F-flortaucipir PET. Plasma pTau181 may be useful to screen for tau pathology associated with AD.
425 citations
TL;DR: A revised 18 item version of the SMBQ satisfies modern measurement standards and offers the opportunity to identify potential clinical cases of burnout using its cut point.
Abstract: Burnout is a mental condition defined as a result of continuous and long-term stress exposure, particularly related to psychosocial factors at work. This paper seeks to examine the psychometric properties of the Shirom-Melamed Burnout Questionnaire (SMBQ) for validation of use in a clinical setting. Data from both a clinical (319) and general population (319) samples of health care and social insurance workers were included in the study. Data were analysed using both classical and modern test theory approaches, including Confirmatory Factor Analysis (CFA) and Rasch analysis. Of the 638 people recruited into the study 416 (65%) persons were working full or part time. Data from the SMBQ failed a CFA, and initially failed to satisfy Rasch model expectations. After the removal of 4 of the original items measuring tension, and accommodating local dependency in the data, model expectations were met. As such, the total score from the revised scale is a sufficient statistic for ascertaining burnout and an interval scale transformation is available. The scale as a whole was perfectly targeted to the joint sample. A cut point of 4.4 for severe burnout was chosen at the intersection of the distributions of the clinical and general population. A revised 18 item version of the SMBQ satisfies modern measurement standards. Using its cut point it offers the opportunity to identify potential clinical cases of burnout.
424 citations
TL;DR: The distribution of HvCEN alleles in a large collection of wild and landrace accessions indicates that this involved selection and enrichment of preexisting genetic variants rather than the acquisition of mutations after domestication.
Abstract: Robbie Waugh and colleagues report that the EARLINESS PER SE (EPS2) locus is associated with spring growth habit and environmental adaptation in barley. Resequencing the barley homolog of CENTRORADIALIS, located within the EPS2 locus, in 216 spring and 207 winter barley accessions identified haplotypes at HvCEN that correspond with winter or spring growth habit. As early farming spread from the Fertile Crescent in the Near East around 10,000 years before the present1, domesticated crops encountered considerable ecological and environmental change. Spring-sown crops that flowered without the need for an extended period of cold to promote flowering and day length–insensitive crops able to exploit the longer, cooler days of higher latitudes emerged and became established. To investigate the genetic consequences of adaptation to these new environments, we identified signatures of divergent selection in the highly differentiated modern-day spring and winter barleys. In one genetically divergent region, we identify a natural variant of the barley homolog of Antirrhinum CENTRORADIALIS2 (HvCEN) as a contributor to successful environmental adaptation. The distribution of HvCEN alleles in a large collection of wild and landrace accessions indicates that this involved selection and enrichment of preexisting genetic variants rather than the acquisition of mutations after domestication.
424 citations
TL;DR: The association between gut microbiota, dietary lipids and lipid metabolism is reviewed and metabolites produced by the gut microbiota such as short-chain fatty acids, secondary bile acids and trimethylamine are reviewed.
Abstract: The gut microbiota is a central regulator of host metabolism. The composition and function of the gut microbiota is dynamic and affected by diet properties such as the amount and composition of lipids. Hence, dietary lipids may influence host physiology through interaction with the gut microbiota. Lipids affect the gut microbiota both as substrates for bacterial metabolic processes, and by inhibiting bacterial growth by toxic influence. The gut microbiota has been shown to affect lipid metabolism and lipid levels in blood and tissues, both in mice and humans. Furthermore, diseases linked to dyslipidemia, such as non-alcoholic liver disease and atherosclerosis, are associated with changes in gut microbiota profile. The influence of the gut microbiota on host lipid metabolism may be mediated through metabolites produced by the gut microbiota such as short-chain fatty acids, secondary bile acids and trimethylamine and by pro-inflammatory bacterially derived factors such as lipopolysaccharide. Here we will review the association between gut microbiota, dietary lipids and lipid metabolism
424 citations
Authors
Showing all 24120 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Peter J. Barnes | 194 | 1530 | 166618 |
| Luigi Ferrucci | 193 | 1601 | 181199 |
| Richard H. Friend | 169 | 1182 | 140032 |
| Napoleone Ferrara | 167 | 494 | 140647 |
| Timothy A. Springer | 167 | 669 | 122421 |
| Anders Björklund | 165 | 769 | 84268 |
| Hua Zhang | 163 | 1503 | 116769 |
| Kaj Blennow | 160 | 1845 | 116237 |
| Leif Groop | 158 | 919 | 136056 |
| Tomas Hökfelt | 158 | 1033 | 95979 |
| Johan G. Eriksson | 156 | 1257 | 123325 |
| Naveed Sattar | 155 | 1326 | 116368 |
| Paul Elliott | 153 | 773 | 103839 |
| Claude Bouchard | 153 | 1076 | 115307 |
| Hakon Hakonarson | 152 | 968 | 101604 |