Institution
University of Gothenburg
Education•Gothenburg, Sweden•
About: University of Gothenburg is a education organization based out in Gothenburg, Sweden. It is known for research contribution in the topics: Population & Health care. The organization has 23855 authors who have published 65241 publications receiving 2606327 citations. The organization is also known as: Göteborg University & Gothenburg University.
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TL;DR: This is the first molecular identification of plant As(III) transport systems and it is proposed that metalloid transport through NIPs is a conserved and ancient feature.
Abstract: Arsenic is a toxic and highly abundant metalloid that endangers human health through drinking water and the food chain. The most common forms of arsenic in the environment are arsenate (As(V)) and arsenite (As(III)). As(V) is a non-functional phosphate analog that enters the food chain via plant phosphate transporters. Inside cells, As(V) becomes reduced to As(III) for subsequent extrusion or compartmentation. Although much is known about As(III) transport and handling in microbes and mammals, the transport systems for As(III) have not yet been characterized in plants. Here we show that the Nodulin26-like Intrinsic Proteins (NIPs) AtNIP5;1 and AtNIP6;1 from Arabidopsis thaliana, OsNIP2;1 and OsNIP3;2 from Oryza sativa, and LjNIP5;1 and LjNIP6;1 from Lotus japonicus are bi-directional As(III) channels. Expression of these NIPs sensitized yeast cells to As(III) and antimonite (Sb(III)), and direct transport assays confirmed their ability to facilitate As(III) transport across cell membranes. On medium containing As(V), expression of the same NIPs improved yeast growth, probably due to increased As(III) efflux. Our data furthermore provide evidence that NIPs can discriminate between highly similar substrates and that they may have differential preferences in the direction of transport. A subgroup of As(III) permeable channels that group together in a phylogenetic tree required N-terminal truncation for functional expression in yeast. This is the first molecular identification of plant As(III) transport systems and we propose that metalloid transport through NIPs is a conserved and ancient feature. Our observations are potentially of great importance for improved remediation and tolerance of plants, and may provide a key to the development of low arsenic crops for food production.
361 citations
TL;DR: In this article, a survey of 494 Swedish residents between 18 and 69 years old found empirical support that egoistic, social-altruistic, and biospheric environmental concerns are related to corresponding awareness-of-consequences beliefs and that both the beliefs and environmental concerns were related to the three value types power, benevolence, and universalism.
361 citations
TL;DR: In this article, the authors test the commonly stated, but rarely investigated, assertion that making political institutions more transparent is an effective method for combating corruption and find that transparency requirements that are implemented by the agent itself are less effective compared to non-agent controlled transparency institutions, such as a free press.
Abstract: We test the commonly stated, but rarely investigated, assertion that making political institutions more transparent is an effective method for combating corruption. This assertion is confirmed with cross-national data, but also specified and qualified in several respects. Most importantly, we find that looking only at average effects gives a misleading picture of the significance of transparency for corruption. Just making information available will not prevent corruption if such conditions for publicity and accountability as education, media circulation and free and fair elections are weak. Furthermore, we find that transparency requirements that are implemented by the agent itself are less effective compared to non-agent controlled transparency institutions, such as a free press. One important implication of these findings is that reforms focusing on increasing transparency should be accompanied by measures for strengthening citizens’ capacity to act upon the available information if we are to see posit...
360 citations
National Institutes of Health1, Centraalbureau voor Schimmelcultures2, University of Perugia3, University of Sydney4, University of Gothenburg5, University of Tennessee6, University of Illinois at Urbana–Champaign7, Royal Botanic Gardens8, University of Tartu9, Purdue University10, Mae Fah Luang University11, Kunming Institute of Botany12, Complutense University of Madrid13, American Museum of Natural History14, University of Pretoria15, Spanish National Research Council16, University of British Columbia17, Academy of Sciences of the Czech Republic18, University of Toronto19, Aberystwyth University20, University of Graz21, University of the Free State22, Commonwealth Scientific and Industrial Research Organisation23, Swedish Museum of Natural History24, Rural Development Administration25, University of California, Davis26, Landcare Research27, Eötvös Loránd University28, Hungarian Academy of Sciences29, Field Museum of Natural History30, University of Szeged31, United States Department of Agriculture32, University of Alabama33, University of Helsinki34, Thailand National Science and Technology Development Agency35, University of Wisconsin-Madison36, National Research Council37, University of North Carolina at Greensboro38, Sungkyunkwan University39, Hirosaki University40, Brandon University41, University of Jena42, University of Findlay43, University of Tübingen44, McMaster University45, Rutgers University46
TL;DR: A set of standards and protocols are proposed to improve the data quality of new sequences, and it is suggested how type and other reference sequences can be used to improve identification of Fungi.
Abstract: DNA phylogenetic comparisons have shown that morphology-based species recognition often underestimates fungal diversity. Therefore, the need for accurate DNA sequence data, tied to both correct taxonomic names and clearly annotated specimen data, has never been greater. Furthermore, the growing number of molecular ecology and microbiome projects using high-throughput sequencing require fast and effective methods for en masse species assignments. In this article, we focus on selecting and re-annotating a set of marker reference sequences that represent each currently accepted order of Fungi. The particular focus is on sequences from the internal transcribed spacer region in the nuclear ribosomal cistron, derived from type specimens and/or ex-type cultures. Re-annotated and verified sequences were deposited in a curated public database at the National Center for Biotechnology Information (NCBI), namely the RefSeq Targeted Loci (RTL) database, and will be visible during routine sequence similarity searches with NR_prefixed accession numbers. A set of standards and protocols is proposed to improve the data quality of new sequences, and we suggest how type and other reference sequences can be used to improve identification of Fungi.
360 citations
National and Kapodistrian University of Athens1, Gunma University2, University of Manchester3, University of Wisconsin-Madison4, University of Southampton5, The Chinese University of Hong Kong6, University of Cape Town7, Swiss Institute of Allergy and Asthma Research8, Washington University in St. Louis9, University of Padua10, National University of Singapore11, Paris Descartes University12, University of Verona13, Duke University14, Creighton University15, Pontifical Catholic University of Chile16, Ain Shams University17, National Health Service18, Medical University of Vienna19, Karolinska Institutet20, University of Virginia21, University of Ulsan22, Chang Gung University23, Stellenbosch University24, Medical University of Łódź25, Charité26, University of South Florida27, Sungkyunkwan University28, University of Colorado Denver29, Nippon Medical School30, Charles University in Prague31, Children's Memorial Hospital32, Royal Children's Hospital33, Federal University of Paraná34, Children's Mercy Hospital35, University of Queensland36, Pontifícia Universidade Católica do Rio Grande do Sul37, Princess Margaret Hospital for Children38, University of Denver39, University of Turku40, Mahidol University41, Nova Southeastern University42, University of Gothenburg43, University of Zurich44, Kaiser Permanente45
TL;DR: The purpose of this document is to highlight the key messages that are common to many of the existing guidelines, while critically reviewing and commenting on any differences, thus providing a concise reference.
Abstract: Asthma is the most common chronic lower respiratory disease in childhood throughout the world. Several guidelines and/or consensus documents are available to support medical decisions on pediatric asthma. Although there is no doubt that the use of common systematic approaches for management can considerably improve outcomes, dissemination and implementation of these are still major challenges. Consequently, the International Collaboration in Asthma, Allergy and Immunology (iCAALL), recently formed by the EAACI, AAAAI, ACAAI, and WAO, has decided to propose an International Consensus on (ICON) Pediatric Asthma. The purpose of this document is to highlight the key messages that are common to many of the existing guidelines, while critically reviewing and commenting on any differences, thus providing a concise reference. The principles of pediatric asthma management are generally accepted. Overall, the treatment goal is disease control. To achieve this, patients and their parents should be educated to optimally manage the disease, in collaboration with healthcare professionals. Identification and avoidance of triggers is also of significant importance. Assessment and monitoring should be performed regularly to re-evaluate and fine-tune treatment. Pharmacotherapy is the cornerstone of treatment. The optimal use of medication can, in most cases, help patients control symptoms and reduce the risk for future morbidity. The management of exacerbations is a major consideration, independent of chronic treatment. There is a trend toward considering phenotype-specific treatment choices; however, this goal has not yet been achieved.
360 citations
Authors
Showing all 24120 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Peter J. Barnes | 194 | 1530 | 166618 |
| Luigi Ferrucci | 193 | 1601 | 181199 |
| Richard H. Friend | 169 | 1182 | 140032 |
| Napoleone Ferrara | 167 | 494 | 140647 |
| Timothy A. Springer | 167 | 669 | 122421 |
| Anders Björklund | 165 | 769 | 84268 |
| Hua Zhang | 163 | 1503 | 116769 |
| Kaj Blennow | 160 | 1845 | 116237 |
| Leif Groop | 158 | 919 | 136056 |
| Tomas Hökfelt | 158 | 1033 | 95979 |
| Johan G. Eriksson | 156 | 1257 | 123325 |
| Naveed Sattar | 155 | 1326 | 116368 |
| Paul Elliott | 153 | 773 | 103839 |
| Claude Bouchard | 153 | 1076 | 115307 |
| Hakon Hakonarson | 152 | 968 | 101604 |