scispace - formally typeset
Search or ask a question
Institution

University of Gothenburg

EducationGothenburg, Sweden
About: University of Gothenburg is a education organization based out in Gothenburg, Sweden. It is known for research contribution in the topics: Population & Poison control. The organization has 23855 authors who have published 65241 publications receiving 2606327 citations. The organization is also known as: Göteborg University & Gothenburg University.


Papers
More filters
Journal ArticleDOI
TL;DR: It is more than likely that in the following decade PC12 cells will continue to serve as a model to study exocytosis, which has some advantages over other models for neurosecretion, including chromaffin cells.
Abstract: This review attempts to touch on the history and application of amperometry at PC12 cells for fundamental investigation into the exocytosis process. PC12 cells have been widely used as a model for neural differentiation and as such they have been used to examine the effects of differentiation on exocytotic release and specifically release at varicosities. In addition, dexamethasone-differentiated cells have been shown to have an increased number of releasable vesicles with increased quantal size, thereby allowing for an even broader range of applications including neuropharmacological and neurotoxicological studies. PC12 cells exhibiting large numbers of events have two distinct pools of vesicles, one about twice the quantal size of the other and each about half the total releasable vesicles. As will be outlined in this review, these cells have served as an extremely useful model of exocytosis in the study of the latency of stimulation-release coupling, the role of exocytotic proteins in regulation of release, effect of drugs on quantal size, autoreceptors, fusion pore biophysics, environmental factors, health and disease. As PC12 cells have some advantages over other models for neurosecretion, including chromaffin cells, it is more than likely that in the following decade PC12 cells will continue to serve as a model to study exocytosis.

351 citations

Journal ArticleDOI
TL;DR: In this paper, the longitudinal association between plasma total cholesterol and triglyceride levels and incident dementia was examined for 392 participants of a 1901 to 1902 birth cohort first examined at age 70, and follow-up examinations were at ages 75, 79, 81, 83, 85, and 88.
Abstract: Objective: To examine the longitudinal association between plasma total cholesterol and triglyceride levels and incident dementia. Methods: Neuropsychiatric, anthropometric, laboratory, and other assessments were conducted for 392 participants of a 1901 to 1902 birth cohort first examined at age 70. Follow-up examinations were at ages 75, 79, 81, 83, 85, and 88. Information on those lost to follow-up was collected from case records, hospital linkage system, and death certificates. Cox proportional hazards regression examined lipid levels at ages 70, 75, and 79 and incident dementia between ages 70 and 88. Results: Increasing cholesterol levels (per mmol/L) at ages 70 (hazard ratio [HR] 0.77, 95% CI: 0.61 to 0.96, p = 0.02), 75 (HR 0.70, CI: 0.52 to 0.93, p = 0.01), and 79 (HR 0.73, CI: 0.55 to 0.98, p = 0.04) were associated with a reduced risk of dementia between ages 79 and 88. Examination of cholesterol levels in quartiles showed that the risk reduction was apparent only among the highest quartile at ages 70 (8.03 to 11.44 mmol/L [311 to 442 mg/dL]; HR 0.31, CI: 0.11 to 0.85, p = 0.03), 75 (7.03 to 9.29 mmol/L [272 to 359 mg/dL]; HR 0.20, CI: 0.05 to 0.75, p = 0.02), and 79 (6.82 to 9.10 mmol/L [264 to 352 mg/dL]; HR 0.45, CI: 0.17 to 1.23, p = 0.12). Triglyceride levels were not associated with dementia. Conclusions: High cholesterol in late life was associated with decreased dementia risk, which is in contrast to previous studies suggesting high cholesterol in mid-life is a risk factor for later dementia. The conflicting results may be explained by the timing of the cholesterol measurements in relationship to age and the clinical onset of dementia.

351 citations

Journal ArticleDOI
TL;DR: Results suggest the presence of an autocrine loop whereby lymphocytes down-regulate their own activity, and intracellular dopamine levels are shown to be increased by extra-cellular dopamine, suggesting a cellular-uptake mechanism.
Abstract: Evidence has been obtained that catecholamines and their metabolites are present in single lymphocytes and extracts of T- and B-cell clones by use of capillary electrophoresis with electrochemical detection. Pharmacological inhibition of tyrosine hydroxylase reduces observed catecholamine levels, suggesting catecholamine synthesis by lymphocytes. Intracellular dopamine levels are shown to be increased by extra-cellular dopamine, suggesting a cellular-uptake mechanism. Furthermore, incubation with either dopamine or L-dihydroxyphenylalanine, a precursor of dopamine, results in a dose-dependent inhibition of lymphocyte proliferation and differentiation. Together, these results suggest the presence of an autocrine loop whereby lymphocytes down-regulate their own activity.

350 citations

Journal ArticleDOI
TL;DR: The stringent response encompasses a mechanism that alters the relative competitiveness of sigma factors in accordance with cellular demands during physiological stress.
Abstract: Many regulons controlled by alternative c factors, including cs and c32, are poorly induced in cells lacking the alarmone ppGpp. We show that ppGpp is not absolutely required for the activity of cs ...

350 citations


Authors

Showing all 24120 results

NameH-indexPapersCitations
Peter J. Barnes1941530166618
Luigi Ferrucci1931601181199
Richard H. Friend1691182140032
Napoleone Ferrara167494140647
Timothy A. Springer167669122421
Anders Björklund16576984268
Hua Zhang1631503116769
Kaj Blennow1601845116237
Leif Groop158919136056
Tomas Hökfelt158103395979
Johan G. Eriksson1561257123325
Naveed Sattar1551326116368
Paul Elliott153773103839
Claude Bouchard1531076115307
Hakon Hakonarson152968101604
Network Information
Related Institutions (5)
Lund University
124.6K papers, 5M citations

96% related

University of Copenhagen
149.7K papers, 5.9M citations

96% related

Karolinska Institutet
121.1K papers, 6M citations

94% related

Utrecht University
139.3K papers, 6.2M citations

92% related

University of Amsterdam
140.8K papers, 5.9M citations

92% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023145
2022539
20215,065
20204,657
20194,254
20183,850