Institution
University of Graz
Education•Graz, Steiermark, Austria•
About: University of Graz is a education organization based out in Graz, Steiermark, Austria. It is known for research contribution in the topics: Population & Quantum chromodynamics. The organization has 17934 authors who have published 37489 publications receiving 1110980 citations. The organization is also known as: Carolo Franciscea Graecensis & Karl Franzens Universität.
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Duke University1, University of Graz2, University of Gdańsk3, Field Museum of Natural History4, University of Oslo5, King Juan Carlos University6, Kaiserslautern University of Technology7, Swiss Federal Institute for Forest, Snow and Landscape Research8, American Museum of Natural History9, University of North Carolina at Chapel Hill10, Academy of Natural Sciences of Drexel University11, Harvard University12, Oregon State University13, University of Arizona14
TL;DR: The phylogenies confirm that ascus morphology cannot be applied consistently to shape the classification of lichen-forming fungi and conclude that a phylogenetic synthesis for a chosen taxonomic group should include a comprehensive assessment of phylogenetic confidence based on multiple estimates using different methods and on a progressive taxon sampling with an increasing number of taxa, even if it involves an increasing amount of missing data.
Abstract: The Lecanoromycetes includes most of the lichen-forming fungal species (>13 500) and is therefore one of the most diverse class of all Fungi in terms of phenotypic complexity. We report phylogeneti...
264 citations
TL;DR: Tryptophan degradation due to immune activation may exert impact on the pathogenesis of AD and increased Kyn/Trp was associated with reduced cognitive performance.
Abstract: Alzheimer's disease (AD) is likely associated with systemic immune activation. During immune response, interferon-gamma stimu-lates indoleamine 2,3-dioxygenase (IDO) converting tryptophan to N-formylkynurenine followed by kynurenine in an ensuing step. Thus, IDO activity is estimated by the kynurenine per tryptophan quotient (Kyn/Trp). In 21 patients suffering from AD, in 20 controls of similar age, and in 49 blood donors we measured serum tryptophan and kynurenine concentrations by HPLC. Lower tryptophan concentrations were found in elderly control subjects compared to blood donors (62.1 vs. 73.0 μM, p < 0.005). Tryptophan concentrations tended to be still lower in AD patients (54.4 μM, p = 0.07) compared to elderly controls. Enhanced tryptophan degradation in patients was reflected by significantly increased Kyn/Trp (46.1 vs. 34.1 in elderly controls, p < 0.05). Correlations were found in patients between Kyn/Trp and concentrations of soluble immune markers in serum, i.e., neopterin, interleukin-2 receptor and tumor necrosis factor receptor (all p < 0.001). Increased Kyn/Trp was associated with reduced cognitive performance. Tryptophan degradation due to immune activation may exert impact on the pathogenesis of AD.
263 citations
TL;DR: Common LRP5 variants are consistently associated with BMD and fracture risk across different white populations and may be the first gene to reach a genome-wide significance level (a conservative level of significance [herein, unadjusted P < 10(-7)] that accounts for the many possible comparisons in the human genome) for a phenotype related to osteoporosis.
Abstract: Context: Mutations in the low-density lipoprotein receptor–related protein 5 (LRP5) gene cause rare syndromes characterized by altered bone mineral density (BMD). More common LRP5 variants may affe ...
263 citations
TL;DR: A high-resolution lake-level record for the Holocene at Lake Accesa (Tuscany, north-central Italy) based on a range of sedimentological techniques validated in previous studies, with a chronology derived from 43 radiocarbon dates and four tephra layers was presented in this article.
263 citations
TL;DR: The efficiency of vitamin E-dependent (= k) and the vitamin independent (= a) oxidation resistance seem to be subject specific with strong individual variation.
Abstract: Human low density lipoprotein (LDL) with a molecular mass of 2.5 million contains on average 1300 molecules of polyunsaturated fatty acids (PUFAs) bound in the different lipid classes. The predominant antioxidant in LDL is a-tocopherol, with an average of 6 molecules in each LDL particle. The other substances with potential antioxidant activity are: gamma-tocopherol, β-carotene, a-carotene, lycopene, cryptoxanthin, cantaxanthin, phytofluene and ubiquinol-10. Each is present in amounts of only 1/ 20th to 1/300th of that of a-tocopherol. If LDL is exposed to oxidative conditions (Cuions, macrophages) a lag phase precedes the oxidation of PUFAs. During the lag phase the antioxidants disappear with a-tocopherol the first to go and β-carotene the last.The lag phase, which can readily be determined, is an index of the oxidation resistance of LDL. If LDL is loaded with vitamin E in vitro its oxidation resistance increases linearly with its a-tocopherol content according to the equation, y=kx+a. The same relation...
263 citations
Authors
Showing all 18136 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| David Haussler | 172 | 488 | 224960 |
| Russel J. Reiter | 169 | 1646 | 121010 |
| Frederik Barkhof | 154 | 1449 | 104982 |
| Philip Scheltens | 140 | 1175 | 107312 |
| Christopher D.M. Fletcher | 138 | 674 | 82484 |
| Jennifer S. Haas | 128 | 840 | 71315 |
| Jelena Krstic | 126 | 839 | 73457 |
| Michael A. Kamm | 124 | 637 | 53606 |
| Frances H. Arnold | 119 | 510 | 49651 |
| Gert Pfurtscheller | 117 | 507 | 62873 |
| Georg Kresse | 111 | 430 | 244729 |
| Manfred T. Reetz | 110 | 959 | 42941 |
| Alois Fürstner | 108 | 459 | 43085 |
| David N. Herndon | 108 | 1227 | 54888 |
| David J. Williams | 107 | 2060 | 62440 |