Institution
University of Graz
Education•Graz, Steiermark, Austria•
About: University of Graz is a education organization based out in Graz, Steiermark, Austria. It is known for research contribution in the topics: Population & Quantum chromodynamics. The organization has 17934 authors who have published 37489 publications receiving 1110980 citations. The organization is also known as: Carolo Franciscea Graecensis & Karl Franzens Universität.
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TL;DR: It is found that Pnpla3 mRNA expression is altered in adipose tissue and liver in response to acute and chronic nutritional challenges, and data argue against a role for PnPla3 loss-of-function in fatty liver disease or metabolic syndrome in mice.
203 citations
TL;DR: The results show that the M287T (T→C) polymorphism in the AS3MT gene, the A222V (C→T) polymorphisms in the MTHFR gene, body mass index, and sex are major factors that influence arsenic metabolism in this population, with a median of 8.0 μg/L arsenic in urine.
Abstract: BACKGROUND: There is a wide variation in susceptibility to health effects of arsenic, which, in part, may be due to differences in arsenic metabolism. Arsenic is metabolized by reduction and methylation reactions, catalyzed by reductases and methyltransferases. OBJECTIVES: Our goal in this study was to elucidate the influence of various demographic and genetic factors on the metabolism of arsenic. METHODS: We studied 415 individuals from Hungary, Romania, and Slovakia by measuring arsenic metabolites in urine using liquid chromatography with hydride generation and inductively coupled plasma mass spectrometry (HPLC-HG-ICPMS). We performed genotyping of arsenic (+III) methyltransferase (AS3MT), glutathione S-transferase omega 1 (GSTO1), and methylene-tetrahydrofolate reductase (MTHFR). RESULTS: The results show that the M287T (T-->C) polymorphism in the AS3MT gene, the A222V (C-->T) polymorphism in the MTHFR gene, body mass index, and sex are major factors that influence arsenic metabolism in this population, with a median of 8.0 microg/L arsenic in urine. Females C) polymorphism in the AS3MT gene on the methylation capacity was much more pronounced in men than in women. CONCLUSIONS: The factors investigated explained almost 20% of the variation seen in the metabolism of arsenic among men and only around 4% of the variation among women. The rest of the variation is probably explained by other methyltransferases backing up the methylation of arsenic.
203 citations
TL;DR: The linkage between La Niña and western US stratospheric intrusions can be exploited to provide a few months of lead time during which preparations could be made to deploy targeted measurements aimed at identifying these exceptional events.
Abstract: Deep stratospheric ozone intrusions can elevate western US ground-level ozone to unhealthy concentrations, but the factors driving interannual variability are poorly understood. Here, the authors combine observations and numerical simulations showing a link between intrusion events and strong La Nina winters.
203 citations
TL;DR: Triaging Pap negative/HPV positive screening test results with p16/Ki-67 Dual-stained cytology may identify women with a high probability of underlying CIN2+ and may efficiently complement HPV-based screening programs to prevent cervical cancer.
203 citations
TL;DR: Findings indicate that beta-blockers decrease melatonin release via specific inhibition of adrenergic beta1- and alpha1-receptors, and further clinical studies should investigate whether or not oral administration of melatonin might avoid this well-known side-effect of beta-blocking.
Abstract: Objective: Melatonin is a mediator in the establishment of the circadian rhythm of biological processes. It is produced in the pineal gland mainly during the night by stimulation of adrenergic beta1- and alpha1-receptors. Sleep disturbances are common side-effects of beta-blockers. The influence of specific beta-blockade as well as that of combined alpha-and beta-blockade on melatonin production has not been investigated in humans before.
203 citations
Authors
Showing all 18136 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| David Haussler | 172 | 488 | 224960 |
| Russel J. Reiter | 169 | 1646 | 121010 |
| Frederik Barkhof | 154 | 1449 | 104982 |
| Philip Scheltens | 140 | 1175 | 107312 |
| Christopher D.M. Fletcher | 138 | 674 | 82484 |
| Jennifer S. Haas | 128 | 840 | 71315 |
| Jelena Krstic | 126 | 839 | 73457 |
| Michael A. Kamm | 124 | 637 | 53606 |
| Frances H. Arnold | 119 | 510 | 49651 |
| Gert Pfurtscheller | 117 | 507 | 62873 |
| Georg Kresse | 111 | 430 | 244729 |
| Manfred T. Reetz | 110 | 959 | 42941 |
| Alois Fürstner | 108 | 459 | 43085 |
| David N. Herndon | 108 | 1227 | 54888 |
| David J. Williams | 107 | 2060 | 62440 |