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Institution

University of Graz

EducationGraz, Steiermark, Austria
About: University of Graz is a education organization based out in Graz, Steiermark, Austria. It is known for research contribution in the topics: Population & Quantum chromodynamics. The organization has 17934 authors who have published 37489 publications receiving 1110980 citations. The organization is also known as: Carolo Franciscea Graecensis & Karl Franzens Universität.


Papers
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Journal ArticleDOI
TL;DR: X-ray diffraction analysis of a human immunodeficiency virus (HIV-1) capsid (CA) protein shows that each monomer within the dimer consists of seven α-helices, five of which are arranged in a coiled coil-like structure.
Abstract: X-ray diffraction analysis of a human immunodeficiency virus (HIV-1) capsid (CA) protein shows that each monomer within the dimer consists of seven alpha-helices, five of which are arranged in a coiled coil-like structure. Sequence assignments were made for two of the helices, and tentative connectivity of the remainder of the protein was confirmed by the recent solution structure of a monomeric N-terminal fragment. The C-terminal third of the protein is mostly disordered in the crystal. The longest helices in the coiled coil-like structure are separated by a long, highly antigenic peptide that includes the binding site of an antibody fragment complexed with CA in the crystal. The site of binding of the Fab, the position of the antigenic loop and the site of cleavage between the matrix protein and CA establish the side of the dimer that would be on the exterior of the retroviral core.

327 citations

Journal ArticleDOI
TL;DR: The utility of BIS monitoring is assessed through examining the various published reports of all BIS values not coinciding with a clinically judged sedative-hypnotic state, whether arising from an underlying pathophysiology of electroencephalographic (EEG) cerebral function or because of shortcomings in the performance and design of the BIS monitor.
Abstract: Since its introduction in 1996, the Bispectral Index (BIS) has gained increasing popularity in daily anesthesia practice. However, numerous reports have been appearing in the literature of paradoxical BIS changes and inaccurate readings. The purpose of this review is to assess the utility of BIS monitoring through examining the various published reports of all BIS values not coinciding with a clinically judged sedative-hypnotic state, whether arising from an underlying pathophysiology of electroencephalographic (EEG) cerebral function or because of shortcomings in the performance and design of the BIS monitor. High electromyographic activity and electric device interference could create subtle artifact signal pollution without their necessarily being displayed as artifacts. This would be misinterpreted by the BIS algorithm as EEG activity and assigned a spuriously increased BIS value. Numerous clinical conditions that have a direct effect on EEG cerebral function could also directly influence the BIS value.

327 citations

Journal ArticleDOI
TL;DR: Clinical criteria for a large number of IEI that were designed in expert panels with an external review are presented and implemented for novel entries and verification of existing data sets from 2014, yielding a substantial refinement.

326 citations

Journal ArticleDOI
TL;DR: Patients receiving antibiotic treatment should avoid food containing high amounts of poorly absorbable carbohydrates and Saccharomyces boulardii and Enterococcus SF68 can reduce the risk of developing AAD.
Abstract: Only 10%-20% of all cases of antibiotic-associated diarrhea (AAD) are caused by infection with Clostridium difficile. Other infectious organisms causing AAD include Clostridium perfringens, Staphylococcus aureus, Klebsiella oxytoca, Candida species, and Salmonella species. Most of the clinically mild AAD cases are due to functional disturbances of intestinal carbohydrate or bile acid metabolism, to allergic and toxic effects of antibiotics on intestinal mucosa, or to pharmacological effects on motility. Saccharomyces boulardii and Enterococcus SF68 can reduce the risk of developing AAD. Patients receiving antibiotic treatment should avoid food containing high amounts of poorly absorbable carbohydrates. Mild cases of AAD that may or may not be caused by C. difficile can be resolved by discontinuation of antibiotic therapy and by dietary carbohydrate reduction. Only severe AAD caused by C. difficile requires specific antibiotic treatment.

324 citations


Authors

Showing all 18136 results

NameH-indexPapersCitations
David Haussler172488224960
Russel J. Reiter1691646121010
Frederik Barkhof1541449104982
Philip Scheltens1401175107312
Christopher D.M. Fletcher13867482484
Jennifer S. Haas12884071315
Jelena Krstic12683973457
Michael A. Kamm12463753606
Frances H. Arnold11951049651
Gert Pfurtscheller11750762873
Georg Kresse111430244729
Manfred T. Reetz11095942941
Alois Fürstner10845943085
David N. Herndon108122754888
David J. Williams107206062440
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023174
2022422
20211,775
20201,759
20191,649
20181,541