University of Grenoble

About: University of Grenoble is a education organization based out in Saint-Martin-d'Hères, France. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 25658 authors who have published 45143 publications receiving 909760 citations.

Possible role of wetlands, permafrost, and methane hydrates in the methane cycle under future climate change: A review

Abstract: We have reviewed the available scientific literature on how natural sources and the atmospheric fate of methane may be affected by future climate change. We discuss how processes governing methane wetland emissions, permafrost thawing, and destabilization of marine hydrates may affect the climate system. It is likely that methane wetland emissions will increase over the next century. Uncertainties arise from the temperature dependence of emissions and changes in the geographical distribution of wetland areas. Another major concern is the possible degradation or thaw of terrestrial permafrost due to climate change. The amount of carbon stored in permafrost, the rate at which it will thaw, and the ratio of methane to carbon dioxide emissions upon decomposition form the main uncertainties. Large amounts of methane are also stored in marine hydrates, and they could be responsible for large emissions in the future. The time scales for destabilization of marine hydrates are not well understood and are likely to be very long for hydrates found in deep sediments but much shorter for hydrates below shallow waters, such as in the Arctic Ocean. Uncertainties are dominated by the sizes and locations of the methane hydrate inventories, the time scales associated with heat penetration in the ocean and sediments, and the fate of methane released in the seawater. Overall, uncertainties are large, and it is difficult to be conclusive about the time scales and magnitudes of methane feedbacks, but significant increases in methane emissions are likely, and catastrophic emissions cannot be ruled out. We also identify gaps in our scientific knowledge and make recommendations for future research and development in the context of Earth system modeling.

Specification-Based Monitoring of Cyber-Physical Systems: A Survey on Theory, Tools and Applications

Abstract: The term Cyber-Physical Systems (CPS) typically refers to engineered, physical and biological systems monitored and/or controlled by an embedded computational core. The behaviour of a CPS over time is generally characterised by the evolution of physical quantities, and discrete software and hardware states. In general, these can be mathematically modelled by the evolution of continuous state variables for the physical components interleaved with discrete events. Despite large effort and progress in the exhaustive verification of such hybrid systems, the complexity of CPS models limits formal verification of safety of their behaviour only to small instances. An alternative approach, closer to the practice of simulation and testing, is to monitor and to predict CPS behaviours at simulation-time or at runtime. In this chapter, we summarise the state-of-the-art techniques for qualitative and quantitative monitoring of CPS behaviours. We present an overview of some of the important applications and, finally, we describe the tools supporting CPS monitoring and compare their main features.

Breaking chirality in nonequilibrium systems

Abstract: At equilibrium, Bloch walls are chiral interfaces between domains with different magnetization. Far from equilibrium, a set of forced oscillators can exhibit walls between states with different phases. In this Letter, we show that when these walls become chiral, they move with a velocity simply related to their chirality. This surprising behavior is a straightforward consequence of nonvariational effects, which are typical of nonequilibrium systems.

Survival Outcomes in Patients With Previously Untreated BRAF Wild-Type Advanced Melanoma Treated With Nivolumab Therapy: Three-Year Follow-up of a Randomized Phase 3 Trial

Abstract: Importance This analysis provides long-term follow-up in patients withBRAFwild-type advanced melanoma receiving first-line therapy based on anti–programmed cell death 1 receptor inhibitors. Objective To compare the 3-year survival with nivolumab vs that with dacarbazine in patients with previously untreatedBRAFwild-type advanced melanoma. Design, Setting, and Participants This follow-up of a randomized phase 3 trial analyzed 3-year overall survival data from the randomized, controlled, double-blind CheckMate 066 phase 3 clinical trial. For this ongoing, multicenter academic institution trial, patients were enrolled from January 2013 through February 2014. Eligible patients were 18 years or older with confirmed unresectable previously untreated stage III or IV melanoma and an Eastern Cooperative Oncology Group performance status of 0 or 1 but without aBRAFmutation. Interventions Patients were treated until progression or unacceptable toxic events with nivolumab (3 mg/kg every 2 weeks plus dacarbazine-matched placebo every 3 weeks) or dacarbazine (1000 mg/m2every 3 weeks plus nivolumab-matched placebo every 2 weeks). Main Outcome and Measure Overall survival. Results At minimum follow-ups of 38.4 months among 210 participants in the nivolumab group (median age, 64 years [range, 18-86 years]; 57.6% male) and 38.5 months among 208 participants in the dacarbazine group (median age, 66 years [range, 25-87 years]; 60.1% male), 3-year overall survival rates were 51.2% (95% CI, 44.1%-57.9%) and 21.6% (95% CI, 16.1%-27.6%), respectively. The median overall survival was 37.5 months (95% CI, 25.5 months–not reached) in the nivolumab group and 11.2 months (95% CI, 9.6-13.0 months) in the dacarbazine group (hazard ratio, 0.46; 95% CI, 0.36-0.59;P Conclusions and Relevance Nivolumab led to improved 3-year overall survival vs dacarbazine in patients with previously untreatedBRAFwild-type advanced melanoma. Trial Registration ClinicalTrials.gov identifier:NCT01721772

Molecular spin qudits for quantum algorithms

Abstract: Presently, one of the most ambitious technological goals is the development of devices working under the laws of quantum mechanics. One prominent target is the quantum computer, which would allow the processing of information at quantum level for purposes not achievable with even the most powerful computer resources. The large-scale implementation of quantum information would be a game changer for current technology, because it would allow unprecedented parallelised computation and secure encryption based on the principles of quantum superposition and entanglement. Currently, there are several physical platforms racing to achieve the level of performance required for the quantum hardware to step into the realm of practical quantum information applications. Several materials have been proposed to fulfil this task, ranging from quantum dots, Bose–Einstein condensates, spin impurities, superconducting circuits, molecules, amongst others. Magnetic molecules are among the list of promising building blocks, due to (i) their intrinsic monodispersity, (ii) discrete energy levels (iii) the possibility of chemical quantum state engineering, and (iv) their multilevel characteristics that lead to Qudits, where the dimension of the Hilbert space is d > 2. Herein we review how a molecular nuclear spin qudit, (d = 4), known as TbPc2, gathers all the necessary requirements to perform as a molecular hardware platform with a first generation of molecular devices enabling even quantum algorithm operations.