University of Grenoble

About: University of Grenoble is a education organization based out in Saint-Martin-d'Hères, France. It is known for research contribution in the topics: Population & Context (language use). The organization has 25658 authors who have published 45143 publications receiving 909760 citations.

Two decades of glacier mass loss along the Andes

Abstract: Andean glaciers are among the fastest shrinking and largest contributors to sea level rise on Earth. They also represent crucial water resources in many tropical and semi-arid mountain catchments. Yet the magnitude of the recent ice loss is still debated. Here we present Andean glacier mass changes (from 10° N to 56° S) between 2000 and 2018 using time series of digital elevation models derived from ASTER stereo images. The total mass change over this period was −22.9 ± 5.9 Gt yr−1 (−0.72 ± 0.22 m w.e. yr−1 (m w.e., metres of water equivalent)), with the most negative mass balances in the Patagonian Andes (−0.78 ± 0.25 m w.e. yr−1) and the Tropical Andes (−0.42 ± 0.24 m w.e. yr−1), compared to relatively moderate losses (−0.28 ± 0.18 m w.e. yr−1) in the Dry Andes. Subperiod analysis (2000–2009 versus 2009–2018) revealed a steady mass loss in the tropics and south of 45° S. Conversely, a shift from a slightly positive to a strongly negative mass balance was measured between 26 and 45° S. In the latter region, the drastic glacier loss in recent years coincides with the extremely dry conditions since 2010 and partially helped to mitigate the negative hydrological impacts of this severe and sustained drought. These results provide a comprehensive, high-resolution and multidecadal data set of recent Andes-wide glacier mass changes that constitutes a relevant basis for the calibration and validation of hydrological and glaciological models intended to project future glacier changes and their hydrological impacts. Glaciers in the Andes have lost about 23 Gt of mass per year between 2000 and 2018, with the fastest loss in Patagonia, according to time series of digital elevation models that are based on ASTER stereo images.

Genome-wide nucleosome specificity and function of chromatin remodellers in ES cells

Abstract: ATP-dependent chromatin remodellers allow access to DNA for transcription factors and the general transcription machinery, but whether mammalian chromatin remodellers target specific nucleosomes to regulate transcription is unclear. Here we present genome-wide remodeller-nucleosome interaction profiles for the chromatin remodellers Chd1, Chd2, Chd4, Chd6, Chd8, Chd9, Brg1 and Ep400 in mouse embryonic stem (ES) cells. These remodellers bind one or both full nucleosomes that flank micrococcal nuclease (MNase)-defined nucleosome-free promoter regions (NFRs), where they separate divergent transcription. Surprisingly, large CpG-rich NFRs that extend downstream of annotated transcriptional start sites are nevertheless bound by non-nucleosomal or subnucleosomal histone variants (H3.3 and H2A.Z) and marked by H3K4me3 and H3K27ac modifications. RNA polymerase II therefore navigates hundreds of base pairs of altered chromatin in the sense direction before encountering an MNase-resistant nucleosome at the 3' end of the NFR. Transcriptome analysis after remodeller depletion reveals reciprocal mechanisms of transcriptional regulation by remodellers. Whereas at active genes individual remodellers have either positive or negative roles via altering nucleosome stability, at polycomb-enriched bivalent genes the same remodellers act in an opposite manner. These findings indicate that remodellers target specific nucleosomes at the edge of NFRs, where they regulate ES cell transcriptional programs.

The Gould's Belt Distances Survey (GOBELINS). I. Trigonometric Parallax Distances and Depth of the Ophiuchus Complex

Abstract: We present the first results of the Gould's Belt Distances Survey (GOBELINS), a project aimed at measuring the proper motion and trigonometric parallax of a large sample of young stars in nearby regions using multi-epoch Very Long Baseline Array (VLBA) radio observations. Enough VLBA detections have now been obtained for 16 stellar systems in Ophiuchus to derive their parallax and proper motion. This leads to distance determinations for individual stars with an accuracy of 0.3 to a few percent. In addition, the orbits of six multiple systems were modelled by combining absolute positions with VLBA (and, in some cases, near-infrared) angular separations. Twelve stellar systems are located in the dark cloud Lynds 1688; the individual distances for this sample are highly consistent with one another and yield a mean parallax for Lynds 1688 of ω = 7.28 ± 0.06 mas, corresponding to a distance d = 137.3 ± 1.2 pc. This represents an accuracy greater than 1%. Three systems for which astrometric elements could be measured are located in the eastern streamer (Lynds 1689) and yield an estimate of ω = 6.79 ± .016 mas, corresponding to a distance d = 147.3 ± 3.4 pc. This suggests that the eastern streamer is located about 10 pc farther than the core, but this conclusion needs to be confirmed by observations of additional sources in the eastern streamer (currently being collected). From the measured proper motions, we estimate the one-dimensional velocity dispersion in Lynds 1688 to be 2.8 ± 1.8 and 3.0 ± 2.0 km s^(−1), in R.A. and decl., respectively; these are larger than, but still consistent within 1σ of, those found in other studies.

The 2010 very high energy gamma-ray flare and 10 years of multi-wavelength observations of M 87

Abstract: The giant radio galaxy M 87 with its proximity (16 Mpc), famous jet, and very massive black hole ((3-6) x 10(9) M-circle dot) provides a unique opportunity to investigate the origin of very high energy (VHE; E > 100 GeV) gamma-ray emission generated in relativistic outflows and the surroundings of supermassive black holes. M 87 has been established as a VHE gamma-ray emitter since 2006. The VHE gamma-ray emission displays strong variability on timescales as short as a day. In this paper, results from a joint VHE monitoring campaign on M 87 by the MAGIC and VERITAS instruments in 2010 are reported. During the campaign, a flare at VHE was detected triggering further observations at VHE (H.E.S.S.), X-rays (Chandra), and radio (43 GHz Very Long Baseline Array, VLBA). The excellent sampling of the VHE gamma-ray light curve enables one to derive a precise temporal characterization of the flare: the single, isolated flare is well described by a two-sided exponential function with significantly different flux rise and decay times of tau(rise)(d) = (1.69 +/- 0.30) days and tau(decay)(d) = (0.611 +/- 0.080) days, respectively. While the overall variability pattern of the 2010 flare appears somewhat different from that of previous VHE flares in 2005 and 2008, they share very similar timescales (similar to day), peak fluxes (Phi(>0.35 TeV) similar or equal to (1-3) x 10(-11) photons cm(-2) s(-1)), and VHE spectra. VLBA radio observations of 43 GHz of the inner jet regions indicate no enhanced flux in 2010 in contrast to observations in 2008, where an increase of the radio flux of the innermost core regions coincided with a VHE flare. On the other hand, Chandra X-ray observations taken similar to 3 days after the peak of the VHE gamma-ray emission reveal an enhanced flux from the core (flux increased by factor similar to 2; variability timescale <2 days). The long-term (2001-2010) multi-wavelength (MWL) light curve of M 87, spanning from radio to VHE and including data from Hubble Space Telescope, Liverpool Telescope, Very Large Array, and European VLBI Network, is used to further investigate the origin of the VHE gamma-ray emission. No unique, common MWL signature of the three VHE flares has been identified. In the outer kiloparsec jet region, in particular in HST-1, no enhanced MWL activity was detected in 2008 and 2010, disfavoring it as the origin of the VHE flares during these years. Shortly after two of the three flares (2008 and 2010), the X-ray core was observed to be at a higher flux level than its characteristic range (determined from more than 60 monitoring observations: 2002-2009). In 2005, the strong flux dominance of HST-1 could have suppressed the detection of such a feature. Published models for VHE gamma-ray emission from M 87 are reviewed in the light of the new data.

Structural Determination of Zn and Pb Binding Sites in Penicillium chrysogenum Cell Walls by EXAFS Spectroscopy

Abstract: Fungal cell walls possess strong complexing properties, which make them valuable biosorbents to remove heavy metals from wastewaters. The binding mechanisms of Zn and Pb to Penicillium chrysogenum ...