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Institution

University of Grenoble

EducationSaint-Martin-d'Hères, France
About: University of Grenoble is a education organization based out in Saint-Martin-d'Hères, France. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 25658 authors who have published 45143 publications receiving 909760 citations.


Papers
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Journal ArticleDOI
01 Oct 1984-Nature
TL;DR: It is reported here that serially cultured adult papilla cells can induce the growth of hair when implanted into follicles which otherwise would not grow hairs.
Abstract: Mammalian hairs are formed by differentiation and keratinization of cells produced in the epidermal matrix (Figs 3, 4). Using the rodent vibrissa follicle as a model1, transplantation studies have shown that the dermal papilla, a discrete population of specialized fibroblasts, is of prime importance in the growth of hair2,3. Papillae induce hair growth when implanted into follicles4,5 and can interact with skin epidermis to form new hair follicles6. When grown in culture, papilla cells display singular morphological and behavioural characteristics compared with connective tissue cells from other skin sources7,8. We report here that serially cultured adult papilla cells can induce the growth of hair when implanted into follicles which otherwise would not grow hairs. This finding presents an opportunity to characterize properties distinguishing the papilla cell population from other skin fibroblasts, and, more specifically, those which control hair growth. The eventual application of this work to human hair replacement techniques can also be envisaged.

629 citations

Journal ArticleDOI
TL;DR: A review of the state of the art in understanding the processes involved in the exchange of trace gases and aerosols between the earth's surface and the atmosphere can be found in this article.

627 citations

Journal ArticleDOI
02 Mar 2016-Neuron
TL;DR: This work reconsider the literature describing HTT-regulated molecular and cellular mechanisms that could be dysfunctional in HD and their possible physiological consequences for patients.

622 citations

Journal ArticleDOI
TL;DR: A consensus between researchers in the field is reported on procedures for testing perovskite solar cell stability, which are based on the International Summit on Organic Photovoltaic Stability (ISOS) protocols, and additional procedures to account for properties specific to PSCs are proposed.
Abstract: Improving the long-term stability of perovskite solar cells is critical to the deployment of this technology. Despite the great emphasis laid on stability-related investigations, publications lack consistency in experimental procedures and parameters reported. It is therefore challenging to reproduce and compare results and thereby develop a deep understanding of degradation mechanisms. Here, we report a consensus between researchers in the field on procedures for testing perovskite solar cell stability, which are based on the International Summit on Organic Photovoltaic Stability (ISOS) protocols. We propose additional procedures to account for properties specific to PSCs such as ion redistribution under electric fields, reversible degradation and to distinguish ambient-induced degradation from other stress factors. These protocols are not intended as a replacement of the existing qualification standards, but rather they aim to unify the stability assessment and to understand failure modes. Finally, we identify key procedural information which we suggest reporting in publications to improve reproducibility and enable large data set analysis. Reliability of stability data for perovskite solar cells is undermined by a lack of consistency in the test conditions and reporting. This Consensus Statement outlines practices for testing and reporting stability tailoring ISOS protocols for perovskite devices.

621 citations

Journal ArticleDOI
TL;DR: An initial bolus and subsequent 2-hour infusion of andexanet substantially reduced anti-factor Xa activity in patients with acute major bleeding associated with factor Xa inhibitors, with effective hemostasis occurring in 79%.
Abstract: BackgroundAndexanet alfa (andexanet) is a recombinant modified human factor Xa decoy protein that has been shown to reverse the inhibition of factor Xa in healthy volunteers. MethodsIn this multicenter, prospective, open-label, single-group study, we evaluated 67 patients who had acute major bleeding within 18 hours after the administration of a factor Xa inhibitor. The patients all received a bolus of andexanet followed by a 2-hour infusion of the drug. Patients were evaluated for changes in measures of anti–factor Xa activity and were assessed for clinical hemostatic efficacy during a 12-hour period. All the patients were subsequently followed for 30 days. The efficacy population of 47 patients had a baseline value for anti–factor Xa activity of at least 75 ng per milliliter (or ≥0.5 IU per milliliter for those receiving enoxaparin) and had confirmed bleeding severity at adjudication. ResultsThe mean age of the patients was 77 years; most of the patients had substantial cardiovascular disease. Bleeding ...

621 citations


Authors

Showing all 25961 results

NameH-indexPapersCitations
Dieter Lutz13967167414
Marcella Bona137139192162
Nicolas Berger137158196529
Cordelia Schmid135464103925
J. F. Macías-Pérez13448694715
Marina Cobal132107885437
Lydia Roos132128489435
Tetiana Hryn'ova131105984260
Johann Collot131101882865
Remi Lafaye131101283281
Jan Stark131118687025
Sabine Crépé-Renaudin129114282741
Isabelle Wingerter-Seez12993079689
James Alexander12988675096
Jessica Levêque129100670208
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023166
2022698
20215,126
20205,328
20195,192
20184,999