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Institution

University of Grenoble

EducationSaint-Martin-d'Hères, France
About: University of Grenoble is a education organization based out in Saint-Martin-d'Hères, France. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 25658 authors who have published 45143 publications receiving 909760 citations.


Papers
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Journal ArticleDOI
TL;DR: An ectopic gene expression signature associated with a subset of highly aggressive tumors, which predicted poor prognosis independently of the TNM (tumor size, node positivity, and metastasis) stage or histological subtype is identified.
Abstract: Activation of normally silent tissue-specific genes and the resulting cell “identity crisis” are the unexplored consequences of malignant epigenetic reprogramming. We designed a strategy for investigating this reprogramming, which consisted of identifying a large number of tissue-restricted genes that are epigenetically silenced in normal somatic cells and then detecting their expression in cancer. This approach led to the demonstration that large-scale “off-context” gene activations systematically occur in a variety of cancer types. In our series of 293 lung tumors, we identified an ectopic gene expression signature associated with a subset of highly aggressive tumors, which predicted poor prognosis independently of the TNM (tumor size, node positivity, and metastasis) stage or histological subtype. The ability to isolate these tumors allowed us to reveal their common molecular features characterized by the acquisition of embryonic stem cell/germ cell gene expression profiles and the down-regulation of immune response genes. The methodical recognition of ectopic gene activations in cancer cells could serve as a basis for gene signature–guided tumor stratification, as well as for the discovery of oncogenic mechanisms, and expand the understanding of the biology of very aggressive tumors.

361 citations

Journal ArticleDOI
Georges Aad1, Brad Abbott2, Jalal Abdallah3, S. Abdel Khalek4  +2871 moreInstitutions (167)
TL;DR: In this article, the authors presented the electron and photon energy calibration achieved with the ATLAS detector using about 25 fb(-1) of LHC proton-proton collision data taken at center-of-mass energies of root s = 7 and 8 TeV.
Abstract: This paper presents the electron and photon energy calibration achieved with the ATLAS detector using about 25 fb(-1) of LHC proton-proton collision data taken at centre-of-mass energies of root s = 7 and 8 TeV. The reconstruction of electron and photon energies is optimised using multivariate algorithms. The response of the calorimeter layers is equalised in data and simulation, and the longitudinal profile of the electromagnetic showers is exploited to estimate the passive material in front of the calorimeter and reoptimise the detector simulation. After all corrections, the Z resonance is used to set the absolute energy scale. For electrons from Z decays, the achieved calibration is typically accurate to 0.05% in most of the detector acceptance, rising to 0.2% in regions with large amounts of passive material. The remaining inaccuracy is less than 0.2-1% for electrons with a transverse energy of 10 GeV, and is on average 0.3% for photons. The detector resolution is determined with a relative inaccuracy of less than 10% for electrons and photons up to 60 GeV transverse energy, rising to 40% for transverse energies above 500 GeV.

361 citations

Journal ArticleDOI
TL;DR: A complex sequence of pyroclastic flows and surges erupted by Nevado del Ruiz volcano on 13 November 1985 interacted with snow and ice on the summit ice cap to trigger catastrophic lahars (volcanic debris flows), which killed more than 23,000 people living at or beyond the base of the volcano.

361 citations

Journal ArticleDOI
Markku Kulmala1, Ari Asmi1, Hanna Lappalainen1, Hanna Lappalainen2, Urs Baltensperger3, J. L. Brenguier, Maria Cristina Facchini4, Hans-Christen Hansson5, Øystein Hov6, Colin D. O'Dowd7, Ulrich Pöschl8, Alfred Wiedensohler9, R. Boers10, Olivier Boucher11, Olivier Boucher12, G. de Leeuw1, G. de Leeuw2, H. A. C. Denier van der Gon, Johann Feichter8, Radovan Krejci5, Paolo Laj13, Heikki Lihavainen2, Ulrike Lohmann14, Gordon McFiggans15, Thomas F. Mentel, Christodoulos Pilinis16, Ilona Riipinen17, Ilona Riipinen1, Michael Schulz6, Andreas Stohl18, Erik Swietlicki19, Elisabetta Vignati, Célia Alves20, Markus Amann21, Markus Ammann3, Sylwester Arabas22, Paulo Artaxo23, Holger Baars9, David C. S. Beddows24, Robert Bergström25, Johan P. Beukes26, Merete Bilde27, John F. Burkhart18, Francesco Canonaco3, Simon L. Clegg28, Hugh Coe15, Suzanne Crumeyrolle29, Barbara D'Anna30, Stefano Decesari4, Stefania Gilardoni, Marc Fischer, A. M. Fjaeraa18, Christos Fountoukis17, Christian George30, L. Gomes, Paul R. Halloran12, Thomas Hamburger, Roy M. Harrison24, Hartmut Herrmann9, Thorsten Hoffmann31, Corinna Hoose32, Min Hu33, Antti-Pekka Hyvärinen2, Urmas Hõrrak34, Yoshiteru Iinuma9, Trond Iversen6, Miroslav Josipovic26, Maria Kanakidou35, Astrid Kiendler-Scharr, Alf Kirkevåg6, Gyula Kiss36, Zbigniew Klimont21, Pekka Kolmonen2, Mika Komppula2, Jón Egill Kristjánsson37, Lauri Laakso2, Lauri Laakso1, Lauri Laakso26, Ari Laaksonen38, Ari Laaksonen2, Laurent C.-Labonnote11, V. A. Lanz3, Kari E. J. Lehtinen2, Kari E. J. Lehtinen38, Luciana V. Rizzo23, Risto Makkonen1, Hanna E. Manninen1, Gavin R. McMeeking15, Joonas Merikanto1, Andreas Minikin, Sander Mirme, William T. Morgan15, Eiko Nemitz, D. O'Donnell8, T. S. Panwar39, Hanna Pawlowska22, Andreas Petzold, Jacobus J. Pienaar26, Casimiro Pio20, C. Plass-Duelmer40, André S. H. Prévôt3, Sara C. Pryor, Carly Reddington41, G. Roberts10, Daniel Rosenfeld42, Joshua P. Schwarz, Øyvind Seland6, Karine Sellegri43, X. J. Shen, Manabu Shiraiwa8, Holger Siebert9, B. Sierau14, David Simpson44, David Simpson6, J. Y. Sun, David Topping15, Peter Tunved5, Petri Vaattovaara38, Ville Vakkari1, J. P. Veefkind10, Antoon Visschedijk, Henri Vuollekoski1, R. Vuolo, Birgit Wehner9, J. Wildt, Simon Woodward12, D. R. Worsnop1, D. R. Worsnop2, G.-J. van Zadelhoff10, A. A. Zardini27, Kai Zhang8, P. G. van Zyl26, Veli-Matti Kerminen2, Kenneth S. Carslaw41, Spyros N. Pandis17 
TL;DR: The European Aerosol Cloud Climate and Air Quality Interactions project (EUCAARI) as mentioned in this paper was the first project to study aerosol processes fron nano to global scale and their effects on climate and air quality.
Abstract: In this paper we describe and summarize the main achievements of the European Aerosol Cloud Climate and Air Quality Interactions project (EUCAARI). EUCAARI started on 1 January 2007 and ended on 31 December 2010 leaving a rich legacy including: (a) a comprehensive database with a year of observations of the physical, chemical and optical properties of aerosol particles over Europe, (b) comprehensive aerosol measurements in four developing countries, (c) a database of airborne measurements of aerosols and clouds over Europe during May 2008, (d) comprehensive modeling tools to study aerosol processes fron nano to global scale and their effects on climate and air quality. In addition a new Pan-European aerosol emissions inventory was developed and evaluated, a new cluster spectrometer was built and tested in the field and several new aerosol parameterizations and computations modules for chemical transport and global climate models were developed and evaluated. These achievements and related studies have substantially improved our understanding and reduced the uncertainties of aerosol radiative forcing and air quality-climate interactions. The EUCAARI results can be utilized in European and global environmental policy to assess the aerosol impacts and the corresponding abatement strategies.

360 citations

Book ChapterDOI
01 Jan 1992
TL;DR: In this paper, a singular hermitian metric on a holomorphic line bundle is introduced as a tool for the study of various algebraic questions, and the coefficients of isolated logarithmic poles of a plurisubharmonic singular metric are shown to have a simple interpretation in terms of the constant e of Seshadri's ampleness criterion.
Abstract: The notion of a singular hermitian metric on a holomorphic line bundle is introduced as a tool for the study of various algebraic questions. One of the main interests of such metrics is the corresponding L2 vanishing theorem for Open image in new window cohomology, which gives a useful criterion for the existence of sections. In this context, numerically effective line bundles and line bundles with maximum Kodaira dimension are characterized by means of positivity properties of the curvature in the sense of currents. The coefficients of isolated logarithmic poles of a plurisubharmonic singular metric are shown to have a simple interpretation in terms of the constant e of Seshadri’s ampleness criterion. Finally, we use singular metrics and approximations of the curvature current to prove a new asymptotic estimate for the dimension of cohomology groups with values in high multiples O(kL) of a line bundle L with maximum Kodaira dimension.

359 citations


Authors

Showing all 25961 results

NameH-indexPapersCitations
Dieter Lutz13967167414
Marcella Bona137139192162
Nicolas Berger137158196529
Cordelia Schmid135464103925
J. F. Macías-Pérez13448694715
Marina Cobal132107885437
Lydia Roos132128489435
Tetiana Hryn'ova131105984260
Johann Collot131101882865
Remi Lafaye131101283281
Jan Stark131118687025
Sabine Crépé-Renaudin129114282741
Isabelle Wingerter-Seez12993079689
James Alexander12988675096
Jessica Levêque129100670208
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023166
2022698
20215,126
20205,328
20195,192
20184,999