Institution
University of Grenoble
Education•Saint-Martin-d'Hères, France•
About: University of Grenoble is a education organization based out in Saint-Martin-d'Hères, France. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 25658 authors who have published 45143 publications receiving 909760 citations.
Topics: Population, Large Hadron Collider, Planet, Nanowire, Stars
Papers published on a yearly basis
Papers
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TL;DR: An ectopic gene expression signature associated with a subset of highly aggressive tumors, which predicted poor prognosis independently of the TNM (tumor size, node positivity, and metastasis) stage or histological subtype is identified.
Abstract: Activation of normally silent tissue-specific genes and the resulting cell “identity crisis” are the unexplored consequences of malignant epigenetic reprogramming. We designed a strategy for investigating this reprogramming, which consisted of identifying a large number of tissue-restricted genes that are epigenetically silenced in normal somatic cells and then detecting their expression in cancer. This approach led to the demonstration that large-scale “off-context” gene activations systematically occur in a variety of cancer types. In our series of 293 lung tumors, we identified an ectopic gene expression signature associated with a subset of highly aggressive tumors, which predicted poor prognosis independently of the TNM (tumor size, node positivity, and metastasis) stage or histological subtype. The ability to isolate these tumors allowed us to reveal their common molecular features characterized by the acquisition of embryonic stem cell/germ cell gene expression profiles and the down-regulation of immune response genes. The methodical recognition of ectopic gene activations in cancer cells could serve as a basis for gene signature–guided tumor stratification, as well as for the discovery of oncogenic mechanisms, and expand the understanding of the biology of very aggressive tumors.
361 citations
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TL;DR: In this article, the authors presented the electron and photon energy calibration achieved with the ATLAS detector using about 25 fb(-1) of LHC proton-proton collision data taken at center-of-mass energies of root s = 7 and 8 TeV.
Abstract: This paper presents the electron and photon energy calibration achieved with the ATLAS detector using about 25 fb(-1) of LHC proton-proton collision data taken at centre-of-mass energies of root s = 7 and 8 TeV. The reconstruction of electron and photon energies is optimised using multivariate algorithms. The response of the calorimeter layers is equalised in data and simulation, and the longitudinal profile of the electromagnetic showers is exploited to estimate the passive material in front of the calorimeter and reoptimise the detector simulation. After all corrections, the Z resonance is used to set the absolute energy scale. For electrons from Z decays, the achieved calibration is typically accurate to 0.05% in most of the detector acceptance, rising to 0.2% in regions with large amounts of passive material. The remaining inaccuracy is less than 0.2-1% for electrons with a transverse energy of 10 GeV, and is on average 0.3% for photons. The detector resolution is determined with a relative inaccuracy of less than 10% for electrons and photons up to 60 GeV transverse energy, rising to 40% for transverse energies above 500 GeV.
361 citations
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TL;DR: A complex sequence of pyroclastic flows and surges erupted by Nevado del Ruiz volcano on 13 November 1985 interacted with snow and ice on the summit ice cap to trigger catastrophic lahars (volcanic debris flows), which killed more than 23,000 people living at or beyond the base of the volcano.
361 citations
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University of Helsinki1, Finnish Meteorological Institute2, Paul Scherrer Institute3, National Research Council4, Stockholm University5, Norwegian Meteorological Institute6, National University of Ireland, Galway7, Max Planck Society8, Leibniz Association9, Royal Netherlands Meteorological Institute10, Centre national de la recherche scientifique11, Met Office12, University of Grenoble13, ETH Zurich14, University of Manchester15, University of the Aegean16, Foundation for Research & Technology – Hellas17, Norwegian Institute for Air Research18, Lund University19, University of Aveiro20, International Institute for Applied Systems Analysis21, University of Warsaw22, University of São Paulo23, University of Birmingham24, University of Gothenburg25, North-West University26, University of Copenhagen27, University of East Anglia28, Blaise Pascal University29, University of Lyon30, University of Mainz31, Karlsruhe Institute of Technology32, Peking University33, University of Tartu34, University of Crete35, Hungarian Academy of Sciences36, University of Oslo37, University of Eastern Finland38, The Energy and Resources Institute39, Deutscher Wetterdienst40, University of Leeds41, Hebrew University of Jerusalem42, University of Clermont-Ferrand43, Chalmers University of Technology44
TL;DR: The European Aerosol Cloud Climate and Air Quality Interactions project (EUCAARI) as mentioned in this paper was the first project to study aerosol processes fron nano to global scale and their effects on climate and air quality.
Abstract: In this paper we describe and summarize the main achievements of the European Aerosol Cloud Climate and Air Quality Interactions project (EUCAARI). EUCAARI started on 1 January 2007 and ended on 31 December 2010 leaving a rich legacy including: (a) a comprehensive database with a year of observations of the physical, chemical and optical properties of aerosol particles over Europe, (b) comprehensive aerosol measurements in four developing countries, (c) a database of airborne measurements of aerosols and clouds over Europe during May 2008, (d) comprehensive modeling tools to study aerosol processes fron nano to global scale and their effects on climate and air quality. In addition a new Pan-European aerosol emissions inventory was developed and evaluated, a new cluster spectrometer was built and tested in the field and several new aerosol parameterizations and computations modules for chemical transport and global climate models were developed and evaluated. These achievements and related studies have substantially improved our understanding and reduced the uncertainties of aerosol radiative forcing and air quality-climate interactions. The EUCAARI results can be utilized in European and global environmental policy to assess the aerosol impacts and the corresponding abatement strategies.
360 citations
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01 Jan 1992TL;DR: In this paper, a singular hermitian metric on a holomorphic line bundle is introduced as a tool for the study of various algebraic questions, and the coefficients of isolated logarithmic poles of a plurisubharmonic singular metric are shown to have a simple interpretation in terms of the constant e of Seshadri's ampleness criterion.
Abstract: The notion of a singular hermitian metric on a holomorphic line bundle is introduced as a tool for the study of various algebraic questions. One of the main interests of such metrics is the corresponding L2 vanishing theorem for Open image in new window cohomology, which gives a useful criterion for the existence of sections. In this context, numerically effective line bundles and line bundles with maximum Kodaira dimension are characterized by means of positivity properties of the curvature in the sense of currents. The coefficients of isolated logarithmic poles of a plurisubharmonic singular metric are shown to have a simple interpretation in terms of the constant e of Seshadri’s ampleness criterion. Finally, we use singular metrics and approximations of the curvature current to prove a new asymptotic estimate for the dimension of cohomology groups with values in high multiples O(kL) of a line bundle L with maximum Kodaira dimension.
359 citations
Authors
Showing all 25961 results
Name | H-index | Papers | Citations |
---|---|---|---|
Dieter Lutz | 139 | 671 | 67414 |
Marcella Bona | 137 | 1391 | 92162 |
Nicolas Berger | 137 | 1581 | 96529 |
Cordelia Schmid | 135 | 464 | 103925 |
J. F. Macías-Pérez | 134 | 486 | 94715 |
Marina Cobal | 132 | 1078 | 85437 |
Lydia Roos | 132 | 1284 | 89435 |
Tetiana Hryn'ova | 131 | 1059 | 84260 |
Johann Collot | 131 | 1018 | 82865 |
Remi Lafaye | 131 | 1012 | 83281 |
Jan Stark | 131 | 1186 | 87025 |
Sabine Crépé-Renaudin | 129 | 1142 | 82741 |
Isabelle Wingerter-Seez | 129 | 930 | 79689 |
James Alexander | 129 | 886 | 75096 |
Jessica Levêque | 129 | 1006 | 70208 |