Institution
University of Grenoble
Education•Saint-Martin-d'Hères, France•
About: University of Grenoble is a education organization based out in Saint-Martin-d'Hères, France. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 25658 authors who have published 45143 publications receiving 909760 citations.
Topics: Population, Large Hadron Collider, Planet, Nanowire, Stars
Papers published on a yearly basis
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INAF1, Pierre-and-Marie-Curie University2, German Aerospace Center3, University of Grenoble4, University of California, Los Angeles5, European Space Research and Technology Centre6, Centre national de la recherche scientifique7, University of Salento8, Polish Academy of Sciences9, California Institute of Technology10, University of Michigan11, University of Perugia12, University of Arizona13, National Central University14, University of Oxford15, Free University of Berlin16, Parthenope University of Naples17, University of Maryland, College Park18, Jet Propulsion Laboratory19
TL;DR: The VIRTIS instrument on board the Rosetta spacecraft has provided evidence of carbon-bearing compounds on the nucleus of the comet 67P/Churyumov-Gerasimenko, and no ice-rich patches are observed, indicating a generally dehydrated nature for the surface currently illuminated by the Sun.
Abstract: The VIRTIS (Visible, Infrared and Thermal Imaging Spectrometer) instrument on board the Rosetta spacecraft has provided evidence of carbon-bearing compounds on the nucleus of the comet 67P/Churyumov-Gerasimenko The very low reflectance of the nucleus (normal albedo of 0060 ± 0003 at 055 micrometers), the spectral slopes in visible and infrared ranges (5 to 25 and 15 to 5% kA−1), and the broad absorption feature in the 29-to-36–micrometer range present across the entire illuminated surface are compatible with opaque minerals associated with nonvolatile organic macromolecular materials: a complex mixture of various types of carbon-hydrogen and/or oxygen-hydrogen chemical groups, with little contribution of nitrogen-hydrogen groups In active areas, the changes in spectral slope and absorption feature width may suggest small amounts of water-ice However, no ice-rich patches are observed, indicating a generally dehydrated nature for the surface currently illuminated by the Sun
350 citations
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TL;DR: The results provide the first evidence that VNS is feasible and appears as an effective tool in the treatment of active CD with a restored vagal tone.
Abstract: The vagus nerve (VN) is a link between the brain and the gut. The VN is a mixed nerve with anti-inflammatory properties through the activation of the hypothalamic-pituitary-adrenal axis by its afferents and by activating the cholinergic anti-inflammatory pathway through its efferents. We have previously shown that VN stimulation (VNS) improves colitis in rats and that the vagal tone is blunted in Crohn's disease (CD) patients. We thus performed a pilot study of chronic VNS in patients with active CD. Seven patients under VNS were followed up for 6 months with a primary endpoint to induce clinical remission and a secondary endpoint to induce biological (CRP and/or fecal calprotectin) and endoscopic remission and to restore vagal tone (heart rate variability). Vagus nerve stimulation was feasible and well-tolerated in all patients. Among the seven patients, two were removed from the study at 3 months for clinical worsening and five evolved toward clinical, biological, and endoscopic remission with a restored vagal tone. These results provide the first evidence that VNS is feasible and appears as an effective tool in the treatment of active CD.
349 citations
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TL;DR: The goal of this review is to address the present knowledge of the effects of high frequency stimulation within the central nervous system and comment on the functional implications of this knowledge for uncovering the mechanism(s) of DBS.
Abstract: High-frequency deep brain stimulation (DBS) of the thalamus or basal ganglia represents an effective clinical technique for the treatment of several medically refractory movement disorders (e.g., Parkinson's disease, essential tremor, and dystonia). In addition, new clinical applications of DBS for other neurologic and psychiatric disorders (e.g., epilepsy and obsessive-compulsive disorder) have been vaulted forward. Although DBS has been effective in the treatment of movement disorders and is rapidly being explored for the treatment of other neurologic disorders, the scientific understanding of its mechanisms of action remains unclear and continues to be debated in the scientific community. Optimization of DBS technology for present and future therapeutic applications will depend on identification of the therapeutic mechanism(s) of action. The goal of this review is to address the present knowledge of the effects of high frequency stimulation within the central nervous system and comment on the functional implications of this knowledge for uncovering the mechanism(s) of DBS. Four general hypotheses have been developed to explain the mechanism(s) of DBS: depolarization blockade, synaptic inhibition, synaptic depression, and stimulation-induced modulation of pathologic network activity. Using the results from microdialysis, neural recording, functional imaging, and neural modeling experiments, the authors address the main hypotheses and attempt to reconcile what have been considered conflicting results from different research modalities.
348 citations
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University of Paris1, Université Paris-Saclay2, Pierre-and-Marie-Curie University3, University of Reims Champagne-Ardenne4, College of William & Mary5, Centre national de la recherche scientifique6, California Institute of Technology7, University of Grenoble8, University of Paris-Sud9, University College London10, Université catholique de Louvain11, university of lille12, University of Massachusetts Lowell13, University of Leicester14, University of Science and Technology of China15, University of Castilla–La Mancha16, Russian Academy of Sciences17, University of Colorado Boulder18, Tomsk Polytechnic University19, University of Cologne20, University of Oslo21, Karlsruhe Institute of Technology22, University of Lethbridge23, University College Cork24, Université libre de Bruxelles25
TL;DR: The GEISA database (Gestion et Etude des Informations Spectroscopiques Atmospheriques: Management and Study of Atmospheric Spectroscopic Information) has been developed and maintained by the ARA/ABC(t) group at LMD since 1974.
347 citations
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TL;DR: GRAVITY as discussed by the authors is a new instrument to coherently combine the light of the European Southern Observatory Very Large Telescope Interferometer to form a telescope with an equivalent 130 m diameter angular resolution and a collecting area of 200 m2.
Abstract: GRAVITY is a new instrument to coherently combine the light of the European Southern Observatory Very Large Telescope Interferometer to form a telescope with an equivalent 130 m diameter angular resolution and a collecting area of 200 m2. The instrument comprises fiber fed integrated optics beam combination, high resolution spectroscopy, built-in beam analysis and control, near-infrared wavefront sensing, phase-tracking, dual-beam operation, and laser metrology. GRAVITY opens up to optical/infrared interferometry the techniques of phase referenced imaging and narrow angle astrometry, in many aspects following the concepts of radio interferometry. This article gives an overview of GRAVITY and reports on the performance and the first astronomical observations during commissioning in 2015/16. We demonstrate phase-tracking on stars as faint as mK ≈ 10 mag, phase-referenced interferometry of objects fainter than mK ≈ 15 mag with a limiting magnitude of mK ≈ 17 mag, minute long coherent integrations, a visibility accuracy of better than 0.25%, and spectro-differential phase and closure phase accuracy better than 0.5°, corresponding to a differential astrometric precision of better than ten microarcseconds (μas). The dual-beam astrometry, measuring the phase difference of two objects with laser metrology, is still under commissioning. First observations show residuals as low as 50 μas when following objects over several months. We illustrate the instrument performance with the observations of archetypical objects for the different instrument modes. Examples include the Galactic center supermassive black hole and its fast orbiting star S2 for phase referenced dual-beam observations and infrared wavefront sensing, the high mass X-ray binary BP Cru and the active galactic nucleus of PDS 456 for a few μas spectro-differential astrometry, the T Tauri star S CrA for a spectro-differential visibility analysis, ξ Tel and 24 Cap for high accuracy visibility observations, and η Car for interferometric imaging with GRAVITY.
347 citations
Authors
Showing all 25961 results
Name | H-index | Papers | Citations |
---|---|---|---|
Dieter Lutz | 139 | 671 | 67414 |
Marcella Bona | 137 | 1391 | 92162 |
Nicolas Berger | 137 | 1581 | 96529 |
Cordelia Schmid | 135 | 464 | 103925 |
J. F. Macías-Pérez | 134 | 486 | 94715 |
Marina Cobal | 132 | 1078 | 85437 |
Lydia Roos | 132 | 1284 | 89435 |
Tetiana Hryn'ova | 131 | 1059 | 84260 |
Johann Collot | 131 | 1018 | 82865 |
Remi Lafaye | 131 | 1012 | 83281 |
Jan Stark | 131 | 1186 | 87025 |
Sabine Crépé-Renaudin | 129 | 1142 | 82741 |
Isabelle Wingerter-Seez | 129 | 930 | 79689 |
James Alexander | 129 | 886 | 75096 |
Jessica Levêque | 129 | 1006 | 70208 |