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Institution

University of Groningen

EducationGroningen, Groningen, Netherlands
About: University of Groningen is a education organization based out in Groningen, Groningen, Netherlands. It is known for research contribution in the topics: Population & Poison control. The organization has 36346 authors who have published 69116 publications receiving 2940370 citations. The organization is also known as: Rijksuniversiteit Groningen & RUG.


Papers
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Journal ArticleDOI
TL;DR: In this paper, the authors present an up-to-date review of the advances made in the field of inventory control of perishable items (deteriorating inventory) and use the classification of Goyal and Giri based on shelf life characteristics and demand characteristics.

546 citations

Journal ArticleDOI
Daniel I. Swerdlow1, David Preiss2, Karoline Kuchenbaecker3, Michael V. Holmes1, Jorgen Engmann1, Tina Shah1, Reecha Sofat1, Stefan Stender4, Paul C. D. Johnson2, Robert A. Scott5, Maarten Leusink6, Niek Verweij, Stephen J. Sharp5, Yiran Guo7, Claudia Giambartolomei1, Christina Chung1, Anne Peasey1, Antoinette Amuzu8, KaWah Li7, Jutta Palmen1, Philip N. Howard1, Jackie A. Cooper1, Fotios Drenos1, Yun Li1, Gordon D.O. Lowe2, John Gallacher9, Marlene C. W. Stewart9, Ioanna Tzoulaki10, Sarah G. Buxbaum4, Daphne L. van der A4, Nita G. Forouhi5, N. Charlotte Onland-Moret4, Yvonne T. van der Schouw4, Renate B. Schnabel11, Jaroslav A. Hubacek12, Ruzena Kubinova13, Migle Baceviciene14, Abdonas Tamosiunas13, Andrzej Pajak15, Romanvan Topor-Madry15, Urszula Stepaniak15, Sofia Malyutina15, Damiano Baldassarre16, Bengt Sennblad17, Elena Tremoli16, Ulf de Faire18, Fabrizio Veglia19, Ian Ford2, J. Wouter Jukema20, Rudi G. J. Westendorp20, Gert J. de Borst4, Pim A. de Jong4, Ale Algra, Wilko Spiering, Anke H. Maitland-van der Zee6, Olaf H. Klungel6, Anthonius de Boer6, Pieter A. Doevendans, Charles B. Eaton21, Jennifer G. Robinson22, David Duggan23, John Kjekshus24, John R. Downs25, Antonio M. Gotto, Anthony C Keech, Roberto Marchioli, Gianni Tognoni26, Peter S. Sever, Neil R Poulter, David D. Waters, Terje R. Pedersen, Pierre Amarenco, Haruo Nakamura, John J.V. McMurray2, James Lewsey3, Daniel I. Chasman27, Paul M. Ridker27, Aldo P. Maggioni28, Luigi Tavazzi28, Kausik K. Ray29, Sreenivasa Rao Kondapally Seshasai29, JoAnn E. Manson27, Jackie F. Price9, Peter H. Whincup30, Richard W Morris1, Debbie A Lawlor31, George Davey Smith31, Yoav Ben-Shlomo31, Pamela J. Schreiner32, Myriam Fornage33, David S. Siscovick34, Mary Cushman35, Meena Kumari1, Nicholas J. Wareham5, W M Monique Verschuren4, Susan Redline36, Sanjay R. Patel36, John C. Whittaker32, Anders Hamsten17, Joseph A.C. Delaney37, Caroline Dale38, Tom R. Gaunt30, Andrew Wong1, Diana Kuh1, Rebecca Hardy1, Sekar Kathiresan, Berta Almoguera Castillo7, Pim van der Harst, Eric J. Brunner1, Anne Tybjærg-Hansen4, Michael Marmot1, Ronald M. Krauss39, Michael Y. Tsai26, Josef Coresh40, Ron C. Hoogeveen40, Bruce M. Psaty34, Leslie A. Lange40, Hakon Hakonarson7, Frank Dudbridge8, Steve E. Humphries1, Philippa J. Talmud1, Mika Kivimäki1, Nicholas J. Timpson31, Claudia Langenberg5, Folkert W. Asselbergs, Mikhail Voevoda15, Martin Bobak1, Hynek Pikhart1, James G. Wilson40, Alexander P. Reiner40, Brendan J. Keating7, Aroon D. Hingorani1, Naveed Sattar2 
TL;DR: The increased risk of type 2 diabetes noted with statins is at least partially explained by HMGCR inhibition.

545 citations

Journal ArticleDOI
TL;DR: The composition and low-resolution structure of Cascade is presented and it is shown how it recognizes double-stranded DNA targets in a sequence-specific manner and suggests that continuous invader DNA surveillance takes place without energy investment.
Abstract: The CRISPR (clustered regularly interspaced short palindromic repeats) immune system in prokaryotes uses small guide RNAs to neutralize invading viruses and plasmids. In Escherichia coli, immunity depends on a ribonucleoprotein complex called Cascade. Here we present the composition and low-resolution structure of Cascade and show how it recognizes double-stranded DNA (dsDNA) targets in a sequence-specific manner. Cascade is a 405-kDa complex comprising five functionally essential CRISPR-associated (Cas) proteins (CasA(1)B(2)C(6)D(1)E(1)) and a 61-nucleotide CRISPR RNA (crRNA) with 5'-hydroxyl and 2',3'-cyclic phosphate termini. The crRNA guides Cascade to dsDNA target sequences by forming base pairs with the complementary DNA strand while displacing the noncomplementary strand to form an R-loop. Cascade recognizes target DNA without consuming ATP, which suggests that continuous invader DNA surveillance takes place without energy investment. The structure of Cascade shows an unusual seahorse shape that undergoes conformational changes when it binds target DNA.

544 citations

Journal ArticleDOI
TL;DR: In this paper, the authors derive the T -duality transformations that transform a general d = 10 solution of the type IIA string with one isometry to a solution of a type IIB string with two isometry and vice versa.

543 citations

Journal ArticleDOI
TL;DR: The results show a surprising similarity between the great tit and a rodent model, suggesting a fundamental principle in the organization of behavioral profiles and suggest variation in selection pressure in time and space and assortative mating are plausible mechanisms accounting for the maintenance of different behavioral profiles within the same population.

542 citations


Authors

Showing all 36692 results

NameH-indexPapersCitations
Ronald C. Kessler2741332328983
Nicholas J. Wareham2121657204896
André G. Uitterlinden1991229156747
Lei Jiang1702244135205
Brenda W.J.H. Penninx1701139119082
Richard H. Friend1691182140032
Panos Deloukas162410154018
Jerome I. Rotter1561071116296
Christopher M. Dobson1501008105475
Dirk Inzé14964774468
Scott T. Weiss147102574742
Dieter Lutz13967167414
Wilmar B. Schaufeli13751395718
Cisca Wijmenga13666886572
Arnold B. Bakker135506103778
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023166
2022543
20214,487
20203,990
20193,283
20182,836