Institution
University of Groningen
Education•Groningen, Groningen, Netherlands•
About: University of Groningen is a education organization based out in Groningen, Groningen, Netherlands. It is known for research contribution in the topics: Population & Poison control. The organization has 36346 authors who have published 69116 publications receiving 2940370 citations. The organization is also known as: Rijksuniversiteit Groningen & RUG.
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TL;DR: The genetic architecture of anorexia nervosa mirrors its clinical presentation, showing significant genetic correlations with psychiatric disorders, physical activity, and metabolic (including glycemic), lipid and anthropometric traits, independent of the effects of common variants associated with body-mass index.
Abstract: Characterized primarily by a low body-mass index, anorexia nervosa is a complex and serious illness1, affecting 0.9-4% of women and 0.3% of men2-4, with twin-based heritability estimates of 50-60%5. Mortality rates are higher than those in other psychiatric disorders6, and outcomes are unacceptably poor7. Here we combine data from the Anorexia Nervosa Genetics Initiative (ANGI)8,9 and the Eating Disorders Working Group of the Psychiatric Genomics Consortium (PGC-ED) and conduct a genome-wide association study of 16,992 cases of anorexia nervosa and 55,525 controls, identifying eight significant loci. The genetic architecture of anorexia nervosa mirrors its clinical presentation, showing significant genetic correlations with psychiatric disorders, physical activity, and metabolic (including glycemic), lipid and anthropometric traits, independent of the effects of common variants associated with body-mass index. These results further encourage a reconceptualization of anorexia nervosa as a metabo-psychiatric disorder. Elucidating the metabolic component is a critical direction for future research, and paying attention to both psychiatric and metabolic components may be key to improving outcomes.
517 citations
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TL;DR: It is found that the CoO band gap is of an intermediate character, between Mott-Hubbard-like and charge-transfer-like, and the first ionization state of CoO is therefore of strongly mixed Co 3d and O 2p character.
Abstract: The electronic structure of ${\mathrm{Li}}_{\mathit{x}}$${\mathrm{Co}}_{1\mathrm{\ensuremath{-}}\mathit{x}}$O (001\ensuremath{\le}x\ensuremath{\le}02), ${\mathrm{LiCoO}}_{2}$, and ${\mathrm{Co}}_{3}$${\mathrm{O}}_{4}$(1% Li) has been investigated using x-ray photoemission spectroscopy (XPS), bremsstrahlung isochromat spectroscopy (BIS), and x-ray-absorption spectroscopy The experimental results are compared with model cluster calculations We find that the CoO band gap is of an intermediate character, between Mott-Hubbard-like and charge-transfer-like The first ionization state of CoO is therefore of strongly mixed Co 3d and O 2p character Its local symmetry corresponds to $^{3}$${\mathit{T}}_{1\mathit{g}}$, similar to an intermediate-spin ${\mathrm{Co}}^{3+}$ state For x\ensuremath{\le}02 the local Co electronic structure is similar to that of CoO However, ${\mathrm{LiCoO}}_{2}$ has a strongly reduced Co-O interatomic distance, resulting in a ligand field strong enough to stabilize a ${\mathrm{Co}}^{3+}$ low-spin ground state ${\mathrm{LiCoO}}_{2}$ is an insulator with a gap of 27 eV From a comparison of the XPS and BIS CoO spectra to the cluster calculations, we find values for U (=53 eV), \ensuremath{\Delta} (=55 eV), and (pd\ensuremath{\sigma}) (=13 eV)
516 citations
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TL;DR: A simulation model is applied to assess the molecular nature of domains formed in ternary mixtures, showing the spontaneous separation of a saturated phosphatidylcholine (PC)/unsaturated PC/cholesterol mixture into a liquid-ordered and aLiquid-disordered phase with structural and dynamic properties closely matching experimental data.
Abstract: Cell membranes contain a large number of different lipid species. Such a multicomponent mixture exhibits a complex phase behavior with regions of structural and compositional heterogeneity. Especially domains formed in ternary mixtures, composed of saturated and unsaturated lipids together with cholesterol, have received a lot of attention as they may resemble raft formation in real cells. Here we apply a simulation model to assess the molecular nature of these domains at the nanoscale, information that has thus far eluded experimental determination. We are able to show the spontaneous separation of a saturated phosphatidylcholine (PC)/unsaturated PC/cholesterol mixture into a liquid-ordered and a liquid-disordered phase with structural and dynamic properties closely matching experimental data. The near-atomic resolution of the simulations reveals remarkable features of both domains and the boundary domain interface. Furthermore, we predict the existence of a small surface tension between the monolayer leaflets that drives registration of the domains. At the level of molecular detail, raft-like lipid mixtures show a surprising face with possible implications for many cell membrane processes.
516 citations
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TL;DR: It is argued that for marine organisms the genetic signatures of northern periglacial and southern refugia can be distinguished from one another, giving credence to recent climatic reconstructions with less extensive glaciation.
Abstract: A goal of phylogeography is to relate patterns of genetic differentiation to potential historical geographic isolating events. Quaternary glaciations, particularly the one culminating in the Last Glacial Maximum ;21 ka (thousands of years ago), greatly affected the distributions and population sizes of temperate marine species as their ranges retreated southward to escape ice sheets. Traditional genetic models of glacial refugia and routes of recolonization include these predictions: low genetic diversity in formerly glaciated areas, with a small number of alleles/haplotypes dominating disproportionately large areas, and high diversity including ''private'' alleles in glacial refugia. In the Northern Hemisphere, low diversity in the north and high diversity in the south are expected. This simple model does not account for the possibility of populations surviving in relatively small northern periglacial refugia. If these periglacial populations experienced extreme bottlenecks, they could have the low genetic diversity expected in recolonized areas with no refugia, but should have more endemic diversity (private alleles) than recently recolonized areas. This review examines evidence of putative glacial refugia for eight benthic marine taxa in the temperate North Atlantic. All data sets were reanalyzed to allow direct comparisons between geographic patterns of genetic diversity and distribution of particular clades and haplotypes including private alleles. We contend that for marine organisms the genetic signatures of northern periglacial and southern refugia can be distinguished from one another. There is evidence for several periglacial refugia in northern latitudes, giving credence to recent climatic reconstructions with less extensive glaciation.
515 citations
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Norwegian University of Science and Technology1, Johns Hopkins University2, University of Groningen3, University of Aberdeen4, University of Southampton5, University of Alberta6, Radboud University Nijmegen7, University of Wisconsin-Madison8, University of British Columbia9, China Medical University (Taiwan)10, National Health Research Institutes11
TL;DR: Both low eGFR and high albuminuria were independently associated with mortality and ESRD regardless of age across a wide range of populations.
Abstract: CONTEXT: Chronic kidney disease (CKD) is prevalent in older individuals, but the risk implications of low estimated glomerular filtration rate (eGFR) and high albuminuria across the full age range ...
515 citations
Authors
Showing all 36692 results
Name | H-index | Papers | Citations |
---|---|---|---|
Ronald C. Kessler | 274 | 1332 | 328983 |
Nicholas J. Wareham | 212 | 1657 | 204896 |
André G. Uitterlinden | 199 | 1229 | 156747 |
Lei Jiang | 170 | 2244 | 135205 |
Brenda W.J.H. Penninx | 170 | 1139 | 119082 |
Richard H. Friend | 169 | 1182 | 140032 |
Panos Deloukas | 162 | 410 | 154018 |
Jerome I. Rotter | 156 | 1071 | 116296 |
Christopher M. Dobson | 150 | 1008 | 105475 |
Dirk Inzé | 149 | 647 | 74468 |
Scott T. Weiss | 147 | 1025 | 74742 |
Dieter Lutz | 139 | 671 | 67414 |
Wilmar B. Schaufeli | 137 | 513 | 95718 |
Cisca Wijmenga | 136 | 668 | 86572 |
Arnold B. Bakker | 135 | 506 | 103778 |