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Institution

University of Groningen

EducationGroningen, Groningen, Netherlands
About: University of Groningen is a education organization based out in Groningen, Groningen, Netherlands. It is known for research contribution in the topics: Population & Poison control. The organization has 36346 authors who have published 69116 publications receiving 2940370 citations. The organization is also known as: Rijksuniversiteit Groningen & RUG.


Papers
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Journal ArticleDOI
TL;DR: In this paper, it was shown that weakly minimum phase nonlinear systems with relative degree one can be globally asymptotically stabilized by smooth state feedback, provided that suitable controllability-like rank conditions are satisfied.
Abstract: Conditions under which a nonlinear system can be rendered passive via smooth state feedback are derived. It is shown that, as in the case of linear systems, this is possible if and only if the system in question has relative degree one and is weakly minimum phase. It is proven that weakly minimum phase nonlinear systems with relative degree one can be globally asymptotically stabilized by smooth state feedback, provided that suitable controllability-like rank conditions are satisfied. This result incorporates and extends a number of stabilization schemes recently proposed for global asymptotic stabilization of certain classes of nonlinear systems. >

1,379 citations

Journal ArticleDOI
TL;DR: The LEDA Traitbase is useful for large-scale analyses of functional responses of communities to environmental change, effects of community trait composition on ecosystem properties and patterns of rarity and invasiveness, as well as linkages between traits as expressions of fundamental trade-offs in plants.
Abstract: Summary 1. An international group of scientists has built an open internet data base of life-history traits of the Northwest European flora (the LEDA-Traitbase) that can be used as a data source for fundamental research on plant biodiversity and coexistence, macro-ecological patterns and plant functional responses. 2. The species-trait matrix comprises referenced information under the control of an editorial board, for ca. 3000 species of the Northwest European flora, combining existing information and additional measurements. The data base currently contains data on 26 plant traits that describe three key features of plant dynamics: persistence, regeneration and dispersal. The LEDA-Traitbase is freely available at www.leda-traitbase.org. 3. We present the structure of the data base and an overview of the trait information available. 4. Synthesis. The LEDA Traitbase is useful for large-scale analyses of functional responses of communities to environmental change, effects of community trait composition on ecosystem properties and patterns of rarity and invasiveness, as well as linkages between traits as expressions of fundamental trade-offs in plants.

1,379 citations

Journal ArticleDOI
Kazuto Kobayashi1, Stanislav Dusko Ehrlich, Alessandra M. Albertini2, G. Amati2, Kasper Krogh Andersen3, Maryvonne Arnaud, Kei Asai4, S. Ashikaga5, Stéphane Aymerich, Philippe Bessières, F. Boland6, S.C. Brignell7, Sierd Bron, Keigo Bunai8, J. Chapuis, L.C. Christiansen, Antoine Danchin, Michel Débarbouillé, Etienne Dervyn, E. Deuerling9, Kevin M. Devine3, Susanne Krogh Devine3, Oliver Dreesen, Jeffery Errington10, Sabine Fillinger7, Simon J. Foster6, Yasutaro Fujita11, Alessandro Galizzi2, Rozenn Gardan, Caroline Eschevins12, Tatsuya Fukushima13, Kazuko Haga, Colin R. Harwood7, Michael Hecker, D. Hosoya14, Marie-Françoise Hullo, Hiroshi Kakeshita8, Dimitri Karamata, Yasuhiro Kasahara, Fujio Kawamura5, K. Koga5, P. Koski, Ritsuko Kuwana15, Daisuke Imamura14, M. Ishimaru14, Shu Ishikawa13, I. Ishio11, D. Le Coq, Anne Masson, Catherine Mauël, Rob Meima12, Rafael P. Mellado, Anne Moir6, Shigeki Moriya, E. Nagakawa11, Hideaki Nanamiya5, S. Nakai, Per Nygaard, Mitsuo Ogura16, T. Ohanan9, Mary O'Reilly3, M. O'Rourke6, Zoltán Prágai7, H.M. Pooley, Georges Rapoport, J.P. Rawlins10, L.A. Rivas, Carlo Rivolta, A. Sadaie, Yoshito Sadaie4, Matti Sarvas, T. Sato14, Hans Henrik Saxild, E. Scanlan3, Wolfgang Schumann9, J.F.M.L. Seegers, Junichi Sekiguchi13, Agnieszka Sekowska, Simone J. Séror, M. Simon, P. Stragier, R. Studer, Hiromu Takamatsu15, Teruo Tanaka16, M. Takeuchi14, H.B. Thomaides10, Valerie Vagner, J.M. van Dijl, Kazuhito Watabe15, Anil Wipat7, Hiroki Yamamoto13, M. Yamamoto11, Y. Yamamoto11, Kunio Yamane8, Katsunori Yata, K. Yoshida11, Hisashi Yoshikawa, Ulrich Zuber, Naotake Ogasawara 
TL;DR: To estimate the minimal gene set required to sustain bacterial life in nutritious conditions, a systematic inactivation of Bacillus subtilis genes was carried out and most genes involved in the Embden–Meyerhof–Parnas pathway are essential.
Abstract: To estimate the minimal gene set required to sustain bacterial life in nutritious conditions, we carried out a systematic inactivation of Bacillus subtilis genes. Among ≈4,100 genes of the organism, only 192 were shown to be indispensable by this or previous work. Another 79 genes were predicted to be essential. The vast majority of essential genes were categorized in relatively few domains of cell metabolism, with about half involved in information processing, one-fifth involved in the synthesis of cell envelope and the determination of cell shape and division, and one-tenth related to cell energetics. Only 4% of essential genes encode unknown functions. Most essential genes are present throughout a wide range of Bacteria, and almost 70% can also be found in Archaea and Eucarya. However, essential genes related to cell envelope, shape, division, and respiration tend to be lost from bacteria with small genomes. Unexpectedly, most genes involved in the Embden–Meyerhof–Parnas pathway are essential. Identification of unknown and unexpected essential genes opens research avenues to better understanding of processes that sustain bacterial life.

1,375 citations

Journal ArticleDOI
22 Jun 2018-Science
TL;DR: It is demonstrated that, in the general population, the personality trait neuroticism is significantly correlated with almost every psychiatric disorder and migraine, and it is shown that both psychiatric and neurological disorders have robust correlations with cognitive and personality measures.
Abstract: Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common variant risk, whereas neurological disorders appear more distinct from one another and from the psychiatric disorders. We also identified significant sharing between disorders and a number of brain phenotypes, including cognitive measures. Further, we conducted simulations to explore how statistical power, diagnostic misclassification, and phenotypic heterogeneity affect genetic correlations. These results highlight the importance of common genetic variation as a risk factor for brain disorders and the value of heritability-based methods in understanding their etiology.

1,357 citations


Authors

Showing all 36692 results

NameH-indexPapersCitations
Ronald C. Kessler2741332328983
Nicholas J. Wareham2121657204896
André G. Uitterlinden1991229156747
Lei Jiang1702244135205
Brenda W.J.H. Penninx1701139119082
Richard H. Friend1691182140032
Panos Deloukas162410154018
Jerome I. Rotter1561071116296
Christopher M. Dobson1501008105475
Dirk Inzé14964774468
Scott T. Weiss147102574742
Dieter Lutz13967167414
Wilmar B. Schaufeli13751395718
Cisca Wijmenga13666886572
Arnold B. Bakker135506103778
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023166
2022543
20214,487
20203,990
20193,283
20182,836