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Institution

University of Groningen

EducationGroningen, Groningen, Netherlands
About: University of Groningen is a education organization based out in Groningen, Groningen, Netherlands. It is known for research contribution in the topics: Population & Poison control. The organization has 36346 authors who have published 69116 publications receiving 2940370 citations. The organization is also known as: Rijksuniversiteit Groningen & RUG.


Papers
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Journal ArticleDOI
TL;DR: The largest declines in risk exposure from 2010 to 2019 were among a set of risks that are strongly linked to social and economic development, including household air pollution; unsafe water, sanitation, and handwashing; and child growth failure.

3,059 citations

Journal ArticleDOI
TL;DR: This update is a supplement to the previous 2002 IIP classification document and outlines advances in the past decade and potential areas for future investigation.
Abstract: Background: In 2002 the American Thoracic Society/European Respiratory Society (ATS/ERS) classification of idiopathic interstitial pneumonias (IIPs) defined seven specific entities, and provided standardized terminology and diagnostic criteria. In addition, the historical “gold standard” of histologic diagnosis was replaced by a multidisciplinary approach. Since 2002 many publications have provided new information about IIPs.Purpose: The objective of this statement is to update the 2002 ATS/ERS classification of IIPs.Methods: An international multidisciplinary panel was formed and developed key questions that were addressed through a review of the literature published between 2000 and 2011.Results: Substantial progress has been made in IIPs since the previous classification. Nonspecific interstitial pneumonia is now better defined. Respiratory bronchiolitis–interstitial lung disease is now commonly diagnosed without surgical biopsy. The clinical course of idiopathic pulmonary fibrosis and nonspecific inte...

2,931 citations

Book
23 Jun 1995
TL;DR: This book presents Semigroup Theory, a treatment of systems theory concepts in finite dimensions with a focus on Hankel Operators and the Nehari Problem.
Abstract: 1 Introduction.- 1.1 Motivation.- 1.2 Systems theory concepts in finite dimensions.- 1.3 Aims of this book.- 2 Semigroup Theory.- 2.1 Strongly continuous semigroups.- 2.2 Contraction and dual semigroups.- 2.3 Riesz-spectral operators.- 2.4 Delay equations.- 2.5 Invariant subspaces.- 2.6 Exercises.- 2.7 Notes and references.- 3 The Cauchy Problem.- 3.1 The abstract Cauchy problem.- 3.2 Perturbations and composite systems.- 3.3 Boundary control systems.- 3.4 Exercises.- 3.5 Notes and references.- 4 Inputs and Outputs.- 4.1 Controllability and observability.- 4.2 Tests for approximate controllability and observability.- 4.3 Input-output maps.- 4.4 Exercises.- 4.5 Notes and references.- 5 Stability, Stabilizability, and Detectability.- 5.1 Exponential stability.- 5.2 Exponential stabilizability and detectability.- 5.3 Compensator design.- 5.4 Exercises.- 5.5 Notes and references.- 6 Linear Quadratic Optimal Control.- 6.1 The problem on a finite-time interval.- 6.2 The problem on the infinite-time interval.- 6.3 Exercises.- 6.4 Notes and references.- 7 Frequency-Domain Descriptions.- 7.1 The Callier-Desoer class of scalar transfer functions.- 7.2 The multivariable extension.- 7.3 State-space interpretations.- 7.4 Exercises.- 7.5 Notes and references.- 8 Hankel Operators and the Nehari Problem.- 8.1 Frequency-domain formulation.- 8.2 Hankel operators in the time domain.- 8.3The Nehari extension problem for state linear systems.- 8.4 Exercises.- 8.5 Notes and references.- 9 Robust Finite-Dimensional Controller Synthesis.- 9.1 Closed-loop stability and coprime factorizations.- 9.2 Robust stabilization of uncertain systems.- 9.3 Robust stabilization under additive uncertainty.- 9.4 Robust stabilization under normalized left-coprime-factor uncertainty.- 9.5 Robustness in the presence of small delays.- 9.6 Exercises.- 9.7 Notes and references.- A. Mathematical Background.- A.1 Complex analysis.- A.2 Normed linear spaces.- A.2.1 General theory.- A.2.2 Hilbert spaces.- A.3 Operators on normed linear spaces.- A.3.1 General theory.- A.3.2 Operators on Hilbert spaces.- A.4 Spectral theory.- A.4.1 General spectral theory.- A.4.2 Spectral theory for compact normal operators.- A.5 Integration and differentiation theory.- A.5.1 Integration theory.- A.5.2 Differentiation theory.- A.6 Frequency-domain spaces.- A.6.1 Laplace and Fourier transforms.- A.6.2 Frequency-domain spaces.- A.6.3 The Hardy spaces.- A.7 Algebraic concepts.- A.7.1 General definitions.- A.7.2 Coprime factorizations over principal ideal domains.- A.7.3 Coprime factorizations over commutative integral domains.- References.- Notation.

2,923 citations

Journal ArticleDOI
Jeffrey D. Stanaway1, Ashkan Afshin1, Emmanuela Gakidou1, Stephen S Lim1  +1050 moreInstitutions (346)
TL;DR: This study estimated levels and trends in exposure, attributable deaths, and attributable disability-adjusted life-years (DALYs) by age group, sex, year, and location for 84 behavioural, environmental and occupational, and metabolic risks or groups of risks from 1990 to 2017 and explored the relationship between development and risk exposure.

2,910 citations

Journal ArticleDOI
01 Dec 1993-Proteins
TL;DR: Analysis of extended molecular dynamics simulations of lysozyme in vacuo and in aqueous solution reveals that it is possible to separate the configurational space into two subspace: an “essential” subspace containing only a few degrees of freedom and the remaining space in which the motion has a narrow Gaussian distribution and which can be considered as “physically constrained.”
Abstract: Analysis of extended molecular dynamics (MD) simulations of lysozyme in vacuo and in aqueous solution reveals that it is possible to separate the configurational space into two subspaces: (1) an "essential" subspace containing only a few degrees of freedom in which anharmonic motion occurs that comprises most of the positional fluctuations; and (2) the remaining space in which the motion has a narrow Gaussian distribution and which can be considered as "physically constrained." If overall translation and rotation are eliminated, the two spaces can be constructed by a simple linear transformation in Cartesian coordinate space, which remains valid over several hundred picoseconds. The transformation follows from the covariance matrix of the positional deviations. The essential degrees of freedom seem to describe motions which are relevant for the function of the protein, while the physically constrained subspace merely describes irrelevant local fluctuations. The near-constraint behavior of the latter subspace allows the separation of equations of motion and promises the possibility of investigating independently the essential space and performing dynamic simulations only in this reduced space.

2,896 citations


Authors

Showing all 36692 results

NameH-indexPapersCitations
Ronald C. Kessler2741332328983
Nicholas J. Wareham2121657204896
André G. Uitterlinden1991229156747
Lei Jiang1702244135205
Brenda W.J.H. Penninx1701139119082
Richard H. Friend1691182140032
Panos Deloukas162410154018
Jerome I. Rotter1561071116296
Christopher M. Dobson1501008105475
Dirk Inzé14964774468
Scott T. Weiss147102574742
Dieter Lutz13967167414
Wilmar B. Schaufeli13751395718
Cisca Wijmenga13666886572
Arnold B. Bakker135506103778
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023166
2022543
20214,487
20203,990
20193,283
20182,836