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Institution

University of Guelph

EducationGuelph, Ontario, Canada
About: University of Guelph is a education organization based out in Guelph, Ontario, Canada. It is known for research contribution in the topics: Population & Poison control. The organization has 26542 authors who have published 50553 publications receiving 1715255 citations. The organization is also known as: U of G & Guelph University.


Papers
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Journal ArticleDOI
TL;DR: The focus here is more on newly-discovered CTL1 choline transporters, expressed in different organisms and cell types apparently not for the biosynthesis of acetylcholine but for the production of the most abundant metabolite of choline, the membrane lipid phosphatidyl choline.
Abstract: Choline is an essential nutrient for all cells because it plays a role in the synthesis of the membrane phospholipid components of the cell membranes, as a methyl-group donor in methionine metabolism as well as in the synthesis of the neurotransmitter acetylcholine. Choline deficiency affects the expression of genes involved in cell proliferation, differentiation, and apoptosis, and it has been associated with liver dysfunction and cancer. Abnormal choline transport and metabolism have been implicated in a number of neurodegenerative disorders such as Alzheimer's and Parkinson's disease. Therefore, the study of choline transport and the characteristics of choline transporters are of central importance to understanding the mechanisms that underlie membrane integrity and cell signaling in such disorders. Kinetic studies with radiolabeled choline and inhibitors distinguish three systems for choline transport: (i) low-affinity facilitated diffusion, (ii) high-affinity, Na+-dependent transport, and (iii) intermediate-affinity, Na+-independent transport. It is only recently, however, that the proteins having transport characteristics of at least one of these systems have been identified. They include (i) polyspecific organic cation transporters (OCTs) with low affinity for choline, (ii) high-affinity choline transporters (CHT1s), and (iii) intermediate-affinity choline transporter-like (CTL1) proteins. CHT1 and CTL1 but not OCT transporters are selectively inhibited with hemicholinium-3 and essentially display characteristics of specialized transporters for targeted choline metabolism. CHT1 is abundant in neurons and almost exclusively supplies choline for acetyl-choline synthesis. The focus here is more on newly-discovered CTL1 choline transporters. They are expressed in different organisms and cell types, apparently not for the biosynthesis of acetylcholine but for the production of the most abundant metabolite of choline, the membrane lipid phosphatidylcholine.

277 citations

Journal ArticleDOI
TL;DR: Preliminary indications to suggest that FMT may also carry therapeutic potential for other conditions such as inflammatory bowel disease, obesity, metabolic syndrome, and functional gastrointestinal disorders.
Abstract: There has been increasing interest in understanding the role of the human gut microbiome to elucidate the therapeutic potential of its manipulation. Fecal microbiota transplantation (FMT) is the administration of a solution of fecal matter from a donor into the intestinal tract of a recipient in order to directly change the recipient’s gut microbial composition and confer a health benefit. FMT has been used to successfully treat recurrent Clostridium difficile infection. There are preliminary indications to suggest that it may also carry therapeutic potential for other conditions such as inflammatory bowel disease, obesity, metabolic syndrome, and functional gastrointestinal disorders.

277 citations

Journal ArticleDOI
TL;DR: It is concluded that DNA barcoding can provide a powerful tool for mayfly species identification and should be considered as a priority for further research.
Abstract: We tested the efficacy of DNA barcodes in identifying mayfly species primarily from the northeastern United States and central Canada. We sequenced a 630-base-pair segment of the mitochondrial gene, cytochrome c oxidase 1 (COI), from 1 individual of each of 80 species to create a reference sequence profile. We used these reference sequences to identify 70 additional specimens representing 32 of the species that were in the profile. DNA barcodes correctly identified 69 of the 70 test specimens. The sole exception was an individual identified morphologically as Maccaffertium modestum that showed deep genetic divergence from other M. modestum specimens. Mean sequence divergence within species was 1%, whereas mean divergence among congeneric species was an order of magnitude greater (18%). We conclude that DNA barcoding can provide a powerful tool for mayfly species identification.

277 citations

Journal ArticleDOI
TL;DR: It is demonstrated that BKME exposure affects reproduction by acting at multiple sites in the pituitary-gonadal axis by reducing responsiveness to the GtH analog human chorionic gonadotropin and to forskolin, a direct activator of adenylate cyclase.

276 citations


Authors

Showing all 26778 results

NameH-indexPapersCitations
Dirk Inzé14964774468
Norbert Perrimon13861073505
Bobby Samir Acharya1331121100545
Eduardo Marbán12957949586
Benoît Roux12049362215
Fereidoon Shahidi11995157796
Stephen Safe11678460588
Mark A. Tarnopolsky11564442501
Robert C. Haddon11257752712
Milton H. Saier11170754496
Hans J. Vogel111126062846
Paul D. N. Hebert11153766288
Peter T. Katzmarzyk11061856484
John Campbell107115056067
Linda F. Nazar10631852092
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202368
2022391
20212,574
20202,547
20192,264
20182,155