University of Guelph

About: University of Guelph is a education organization based out in Guelph, Ontario, Canada. It is known for research contribution in the topics: Population & Gene. The organization has 26542 authors who have published 50553 publications receiving 1715255 citations. The organization is also known as: U of G & Guelph University.

Electronic survey methodology: A case study in reaching hard-to-involve internet users.

Abstract: Using the Internet to conduct quantitative research presents challenges not found in conventional research. Paper-based survey quality criteria cannot be completely adapted to electronic formats. Electronic surveys have distinctive technological, demographic, and response characteristics that affect their design, use, and implementation. Survey design, participant privacy and confidentiality, sampling and subject solicitation, distribution methods and response rates, and survey piloting are critical methodological components that must be addressed. In this article, quality criteria for electronic survey design and use based on an investigation of recent electronic survey literature are presented. The application of these criteria to reach a hard-to-involve online population-nonpublic participants of online communities (also known as "lurkers")-and survey them on their community participation, a topic not salient to the purpose of their online communities is demonstrated in a case study. The results show t...

A Transaction Cost Analysis Model of Channel Integration in International Markets

Abstract: The authors develop a transaction cost analysis model designed to explain the channel integration choices of firms in international markets. In a test with data collected from a group of Canadian e...

Multiple Discrepancies Theory (MDT)

Abstract: A fairly thorough account of multiple discrepancies theory (MDT) is presented, with a review of its historical antecedents and an examination of its strength in accounting for the happiness (H) and satisfaction (S) of nearly 700 university undergraduates. Basically, MDT asserts that H and S are functions of perceived gaps between what one has and wants, relevant others have, the best one has had in the past, expected to have 3 years ago, expects to have after 5 years, deserves and needs. MDT explained 49% of the variance in H, 53% in global S and 50% or more in 7 out of 12 domain S scores. The domains studied were health, finances, family, job, friendships, housing, area, recreation, religion, self-esteem, transportation and education.

Microbial and animal rhodopsins: structures, functions, and molecular mechanisms.

Abstract: Organisms of all domains of life use photoreceptor proteins to sense and respond to light. The light-sensitivity of photoreceptor proteins arises from bound chromophores such as retinal in retinylidene proteins, bilin in biliproteins, and flavin in flavoproteins. Rhodopsins found in Eukaryotes, Bacteria, and Archaea consist of opsin apoproteins and a covalently linked retinal which is employed to absorb photons for energy conversion or the initiation of intra- or intercellular signaling.1 Both functions are important for organisms to survive and to adapt to the environment. While lower organisms utilize the family of microbial rhodopsins for both purposes, animals solely use a different family of rhodopsins, a specialized subset of G-protein-coupled receptors (GPCRs).1,2 Animal rhodopsins, for example, are employed in visual and nonvisual phototransduction, in the maintenance of the circadian clock and as photoisomerases.3,4 While sharing practically no sequence similarity, microbial and animal rhodopsins, also termed type-I and type-II rhodopsins, respectively, share a common architecture of seven transmembrane α-helices (TM) with the N- and C-terminus facing out- and inside of the cell, respectively (Figure ​(Figure11).1,5 Retinal is attached by a Schiff base linkage to the e-amino group of a lysine side chain in the middle of TM7 (Figures ​(Figures11 and ​and2).2). The retinal Schiff base (RSB) is protonated (RSBH+) in most cases, and changes in protonation state are integral to the signaling or transport activity of rhodopsins. Figure 1 Topology of the retinal proteins. (A) These membrane proteins contain seven α-helices (typically denoted helix A to G in microbial opsins and TM1 to 7 in the animal opsins) spanning the lipid bilayer. The N-terminus faces the outside of the cell ...