University of Haifa

About: University of Haifa is a education organization based out in Haifa, Israel. It is known for research contribution in the topics: Population & Poison control. The organization has 7558 authors who have published 27141 publications receiving 711629 citations. The organization is also known as: Haifa University & Universiṭat Ḥefah.

Regulation of Nrf2 signaling and longevity in naturally long-lived rodents

Abstract: The preternaturally long-lived naked mole-rat, like other long-lived species and experimental models of extended longevity, is resistant to both endogenous (e.g., reactive oxygen species) and environmental stressors and also resists age-related diseases such as cancer, cardiovascular disease, and neurodegeneration. The mechanisms behind the universal resilience of longer-lived organisms to stress, however, remain elusive. We hypothesize that this resilience is linked to the activity of a highly conserved transcription factor, nuclear factor erythroid 2-related factor (Nrf2). Nrf2 regulates the transcription of several hundred cytoprotective molecules, including antioxidants, detoxicants, and molecular chaperones (heat shock proteins). Nrf2 itself is tightly regulated by mechanisms that either promote its activity or increase its degradation. We used a comparative approach and examined Nrf2-signaling activity in naked mole-rats and nine other rodent species with varying maximum lifespan potential (MLSP). We found that constitutive Nrf2-signaling activity was positively correlated (P = 0.0285) with MLSP and that this activity was also manifested in high levels of downstream gene expression and activity. Surprisingly, we found that species longevity was not linked to the protein levels of Nrf2 itself, but rather showed a significant (P < 0.01) negative relationship with the regulators Kelch-like ECH-Associated Protein 1 (Keap1) and β-transducin repeat-containing protein (βTrCP), which target Nrf2 for degradation. These findings highlight the use of a comparative biology approach for the identification of evolved mechanisms that contribute to health span, aging, and longevity.

Interventions targeting mental health self-stigma: A review and comparison.

Abstract: Objective With growing awareness of the impact of mental illness self-stigma, interest has arisen in the development of interventions to combat it. The present article briefly reviews and compares interventions targeting self-stigma to clarify the similarities and important differences between the interventions.

Portfolios as evidence of reflective practice: what remains ‘untold’

Abstract: Addressing recent calls for investigating the specific quality of reflection associated with the uses of portfolios in teacher education, this paper describes and interprets the ‘practice of portfolio construction’ as revealed in the construction and presentation of two kinds of portfolio in two in-service courses for mentors of teachers in Israel: a ‘process’ portfolio and a ‘product’ portfolio. The study revealed that the language of practice and form of reflection bore striking similarities across the two practices of portfolio construction, regardless of their differences in content, purpose, organization and the degree of intervention of the course instructors in its construction. In both types of portfolios, the mentors described their learning mostly at technical levels of reflection. This tendency raises the question of whether the genre of portfolio writing, inevitably bound by institutional constraints, is generically conducive to reflecting on controversial experiences at interpretative, critic...

Solidarity–Conflict and Ambivalence: Testing Two Conceptual Frameworks and Their Impact on Quality of Life for Older Family Members

Abstract: Objectives. The purpose of this study was to test empirically two major conceptualizations of parent–child relations in later adulthood—intergenerational solidarity–conflict and ambivalence paradigms—and their predictive validity on elders’ quality of life using comparative cross-national data. Methods. Data were from a sample of 2,064 elders (aged 75 and older) from the five-country OASIS study (Old Age and Autonomy: The Role of Service Systems and Intergenerational Family Solidarity; Norway, England, Germany, Spain, and Israel). Multivariate and block-recursive regression models estimated the predictivity of the two conceptualizations of family dynamics on quality of life controlling for country, personal characteristics, and activity of daily living functioning. Results. Descriptive analyses indicated that family solidarity, especially the affective/cognitive component (called Solidarity A), was high in all five countries, whereas conflict and ambivalence were low. When I entered all three constructs into the regression Solidarity A, reciprocal intergenerational support and ambivalence predicted quality of life. Controlling for activity of daily living functioning, socioeconomics status, and country, intergenerational relations had only a weak explanatory power, and personal resources explained most of the variance. Discussion. The data suggest that the three constructs exist simultaneously but in varying combinations, confirming that in cross-cultural contexts family cohesion predominates, albeit with low degrees of conflict and ambivalence. The solidarity construct evidenced relatively robust measurement. More work is required to enhance the ambivalence measurement.

Differences in Patterns of Participation Between Youths With Cerebral Palsy and Typically Developing Peers

Abstract: OBJECTIVE. This study investigated the effects of cerebral palsy (CP) and gender on youth participation in activities outside of formal school. METHOD. Twenty-two participants with CP and 30 typically developing peers, ages 12�16 years, completed the Children's Assessment of Participation and Enjoyment (CAPE; King et al., 2004). RESULTS. Typically developing youths engaged in a broader range of activities and did so more frequently than did youths with CP. Similar levels of enjoyment in activity were found in both groups. In some scales of the CAPE, youths with CP participated in proportionally more activities alone and at home. Gender differences and Group ×Gender interaction were found in some scales with respect to participation in and enjoyment of activities. CONCLUSIONS. Physical limitations associated with CP may affect the frequency of a child's participation in activity outside of school. However, youths with CP may express levels of enjoyment similar to those of typically developing peers while participating in activity